Search Results - "Matias-Guiu Xavier"

Molecular pathology of endometrial carcinoma by Matias-Guiu, Xavier, Prat, Jaime

“…This review paper discusses the main molecular alterations of endometrial carcinoma, the most common cancer of the female genital tract. Two…”
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Clinicopathological and molecular characterisation of ‘multiple‐classifier’ endometrial carcinomas by León‐Castillo, Alicia, Gilvazquez, Ester, Nout, Remi, Smit, Vincent THBM, McAlpine, Jessica N, McConechy, Melissa, Kommoss, Stefan, Brucker, Sara Y, Carlson, Joseph W, Epstein, Elisabeth, Rau, Tilman T, Soslow, Robert A, Ganesan, Raji, Matias‐Guiu, Xavier, Oliva, Esther, Harrison, Beth T, Church, David N, Gilks, C Blake, Bosse, Tjalling

“…Endometrial carcinoma (EC) molecular classification based on four molecular subclasses identified in The Cancer Genome Atlas (TCGA) has gained relevance in…”
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Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis by Moran, Sebastian, MSc, Martínez-Cardús, Anna, PhD, Sayols, Sergi, MSc, Musulén, Eva, MD, Balañá, Carme, MD, Estival-Gonzalez, Anna, MD, Moutinho, Cátia, PhD, Heyn, Holger, PhD, Diaz-Lagares, Angel, PhD, de Moura, Manuel Castro, MSc, Stella, Giulia M, MD, Comoglio, Paolo M, Prof, Ruiz-Miró, Maria, PhD, Matias-Guiu, Xavier, MD, Pazo-Cid, Roberto, MD, Antón, Antonio, MD, Lopez-Lopez, Rafael, MD, Soler, Gemma, MD, Longo, Federico, MD, Guerra, Isabel, MD, Fernandez, Sara, MD, Assenov, Yassen, PhD, Plass, Christoph, Prof, Morales, Rafael, MD, Carles, Joan, MD, Bowtell, David, Prof, Mileshkin, Linda, MD, Sia, Daniela, PhD, Tothill, Richard, PhD, Tabernero, Josep, MD, Llovet, Josep M, Prof, Esteller, Manel, Prof

“…Summary Background Cancer of unknown primary ranks in the top ten cancer presentations and has an extremely poor prognosis. Identification of the primary…”
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WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion by Rodriguez-Hernandez, Irene, Maiques, Oscar, Kohlhammer, Leonie, Cantelli, Gaia, Perdrix-Rosell, Anna, Monger, Joanne, Fanshawe, Bruce, Bridgeman, Victoria L., Karagiannis, Sophia N., Penin, Rosa M., Marcolval, Joaquim, Marti, Rosa M., Matias-Guiu, Xavier, Fruhwirth, Gilbert O., Orgaz, Jose L., Malanchi, Ilaria, Sanz-Moreno, Victoria

“…Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive…”
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Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma by Castilla, María Ángeles, Moreno-Bueno, Gema, Romero-Pérez, Laura, De Vijver, Koen Van, Biscuola, Michele, López-García, María Ángeles, Prat, Jaime, Matías-Guiu, Xavier, Cano, Amparo, Oliva, Esther, Palacios, José

“…Endometrial carcinosarcomas (ECSs) undergo a true epithelial-mesenchymal transition (EMT). The molecular determinants of the EMT in vivo are unclear, although…”
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Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways by Cuppens, Tine, Moisse, Matthieu, Depreeuw, Jeroen, Annibali, Daniela, Colas, Eva, Gil‐Moreno, Antonio, Huvila, Jutta, Carpén, Olli, Zikán, Michal, Matias‐Guiu, Xavier, Moerman, Philippe, Croce, Sabrina, Lambrechts, Diether, Amant, Frédéric

“…Uterine leiomyosarcomas (uLMS) are rare, aggressive malignancies for which limited treatment options are available. To gain novel molecular insights into uLMS…”
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Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy‐mediated drug resistance in ovarian cancer cells, xenografts, and patient‐derived xenograft models by Santiago‐O’Farrill, Janice M., Weroha, S. John, Hou, Xiaonan, Oberg, Ann L., Heinzen, Ethan P., Maurer, Matthew J., Pang, Lan, Rask, Philip, Amaravadi, Ravi K., Becker, Sarah E., Romero, Ignacio, Rubio, Ma Jesús, Matias‐Guiu, Xavier, Santacana, Maria, Llombart‐Cussac, Antonio, Poveda, Andrés, Lu, Zhen, Bast, Robert C.

“…Background Poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors exhibit promising activity against ovarian cancers, but their efficacy can be…”
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New perspectives on screening and early detection of endometrial cancer by Costas, Laura, Frias‐Gomez, Jon, Guardiola, Magdalena, Benavente, Yolanda, Pineda, Marta, Pavón, Miquel Á., Martínez, José M., Climent, Maite, Barahona, Marc, Canet, Júlia, Paytubi, Sonia, Salinas, Mónica, Palomero, Luis, Bianchi, Ilaria, Reventós, Jaume, Capellà, Gabriel, Diaz, Mireia, Vidal, August, Piulats, Josep M., Aytés, Álvaro, Ponce, Jordi, Brunet, Joan, Bosch, Francesc X., Matias‐Guiu, Xavier, Alemany, Laia, Sanjosé, Silvia

“…Due to the anatomical continuity of the uterine cavity with the cervix, genomic exploitation of material from routine Pap smears and other noninvasive sampling…”
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Intratumour heterogeneity in endometrial serous carcinoma assessed by targeted sequencing and multiplex ligation‐dependent probe amplification: a descriptive study by Cuevas, Dolors, Velasco, Ana, Vaquero, Marta, Santacana, Maria, Gatius, Sònia, Eritja, Núria, Estaran, Elena, Matias‐Guiu, Xavier

“…Aims Endometrial serous carcinoma (ESC) represents the most aggressive subtype of endometrial carcinoma (EC). According to The Cancer Genome Atlas (TCGA), ESC…”
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CTCs‐derived xenograft development in a triple negative breast cancer case by Pereira‐Veiga, Tais, Abreu, Manuel, Robledo, Diego, Matias‐Guiu, Xavier, Santacana, María, Sánchez, Laura, Cueva, Juan, Palacios, Patricia, Abdulkader, Ihab, López‐López, Rafael, Muinelo‐Romay, Laura, Costa, Clotilde

“…Triple‐negative breast cancer (TNBC) is characterized by high rates of metastasis and no available molecular targets. CTCs derived xenografts (CDX) have…”
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Genomic profiling of primary and recurrent adult granulosa cell tumors of the ovary by Da Cruz Paula, Arnaud, da Silva, Edaise M., Segura, Sheila E., Pareja, Fresia, Bi, Rui, Selenica, Pier, Kim, Sarah H., Ferrando, Lorenzo, Vahdatinia, Mahsa, Soslow, Robert A., Vidal, August, Gatius, Sonia, Przybycin, Christopher G., Abu-Rustum, Nadeem R., Matias-Guiu, Xavier, Rubin, Brian P., Reis-Filho, Jorge S., DeLair, Deborah F., Weigelt, Britta

“…Adult-type granulosa cell tumor (aGCT) is a rare malignant ovarian sex cord-stromal tumor, harboring recurrent FOXL2 c.C402G/p.C134W hotspot mutations in 97%…”
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Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing by Le Gallo, Matthieu, Rudd, Meghan L., Urick, Mary Ellen, Hansen, Nancy F., Zhang, Suiyuan, Lozy, Fred, Sgroi, Dennis C., Vidal Bel, August, Matias‐Guiu, Xavier, Broaddus, Russell R., Lu, Karen H., Levine, Douglas A., Mutch, David G., Goodfellow, Paul J., Salvesen, Helga B., Mullikin, James C., Bell, Daphne W.

“…BACKGROUND The molecular pathogenesis of clear cell endometrial cancer (CCEC), a tumor type with a relatively unfavorable prognosis, is not well defined. We…”
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SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade by Romero, Octavio A., Vilarrubi, Andrea, Alburquerque-Bejar, Juan J., Gomez, Antonio, Andrades, Alvaro, Trastulli, Deborah, Pros, Eva, Setien, Fernando, Verdura, Sara, Farré, Lourdes, Martín-Tejera, Juan F., Llabata, Paula, Oaknin, Ana, Saigi, Maria, Piulats, Josep M., Matias-Guiu, Xavier, Medina, Pedro P., Vidal, August, Villanueva, Alberto, Sanchez-Cespedes, Montse

“…Despite the genetic inactivation of SMARCA4 , a core component of the SWI/SNF-complex commonly found in cancer, there are no therapies that effectively target…”
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Novel POLE pathogenic germline variant in a family with multiple primary tumors results in distinct mutational signatures by Castellsagué, Ester, Li, Rui, Aligue, Rosa, González, Sara, Sanz, Judit, Martin, Edgar, Velasco, Àngela, Capellá, Gabriel, Stewart, Colin J. R., Vidal, August, Majewski, Jacek, Rivera, Barbara, Polak, Paz, Matias‐Guiu, Xavier, Brunet, Joan, Foulkes, William D.

“…We describe a family in which four siblings exhibited multiple or classic colonic polyposis with or without colorectal carcinoma (CRC). One female developed…”
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Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors by Lahiguera, Álvaro, Hyroššová, Petra, Figueras, Agnès, Garzón, Diana, Moreno, Roger, Soto‐Cerrato, Vanessa, McNeish, Iain, Serra, Violeta, Lazaro, Conxi, Barretina, Pilar, Brunet, Joan, Menéndez, Javier, Matias‐Guiu, Xavier, Vidal, August, Villanueva, Alberto, Taylor‐Harding, Barbie, Tanaka, Hisashi, Orsulic, Sandra, Junza, Alexandra, Yanes, Oscar, Muñoz‐Pinedo, Cristina, Palomero, Luís, Pujana, Miquel Àngel, Perales, José Carlos, Viñals, Francesc

“…Mitochondrial metabolism and the generation of reactive oxygen species (ROS) contribute to the acquisition of DNA mutations and genomic instability in cancer…”
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Sensitivity of cervico‐vaginal cytology in endometrial carcinoma: A systematic review and meta‐analysis by Frias‐Gomez, Jon, Benavente, Yolanda, Ponce, Jordi, Brunet, Joan, Ibáñez, Raquel, Peremiquel‐Trillas, Paula, Baixeras, Nuria, Zanca, Alba, Piulats, Josep Maria, Aytés, Álvaro, Matias‐Guiu, Xavier, Bosch, Francesc Xavier, Sanjosé, Silvia, Alemany, Laia, Costas, Laura

“…Cervico‐vaginal cytology is primarily a cervical cancer screening test. The anatomical continuity of the uterine cavity with the cervix makes the Papanicolaou…”
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Epithelial-to-mesenchymal transition and stem cells in endometrial cancer by Mirantes, Cristina, MSc, Espinosa, Iñigo, MD, PhD, Ferrer, Irene, PhD, Dolcet, Xavier, PhD, Prat, Jaime, MD, PhD, Matias-Guiu, Xavier, MD, PhD

“…Summary This review article describes the main features of epithelial-to-mesenchymal transition (EMT) and its possible role in understanding myometrial…”
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The WID‐EC test for the detection and risk prediction of endometrial cancer by Barrett, James E., Jones, Allison, Evans, Iona, Herzog, Chiara, Reisel, Daniel, Olaitan, Adeola, Mould, Tim, MacDonald, Nicola, Doufekas, Konstantinos, Newton, Claire, Crosbie, Emma J., Bjørge, Line, Colombo, Nicoletta, Dostalek, Lukas, Costas, Laura, Peremiquel‐Trillas, Paula, Ponce, Jordi, Matias‐Guiu, Xavier, Zikan, Michal, Cibula, David, Wang, Jiangrong, Sundström, Karin, Dillner, Joakim, Widschwendter, Martin

“…The incidence of endometrial cancer is rising. Measures to identify women at risk and to detect endometrial cancer earlier are required to reduce the morbidity…”
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Detection of somatic mutations in peritoneal lavages and plasma of endometrial cancer patients: A proof‐of‐concept study by Mayo‐de‐las‐Casas, Clara, Velasco, Ana, Sanchez, Douglas, Martínez‐Bueno, Alejandro, Garzón‐Ibáñez, Mónica, Gatius, Sònia, Ruiz‐Miró, Maria, Gonzalez‐Tallada, Xavier, Llordella, Ivana, Tresserra, Francesc, Rodríguez, Sonia, Aldeguer, Erika, Roman‐Canal, Berta, Bertran‐Alamillo, Jordi, García‐Peláez, Beatriz, Rosell, Rafael, Molina‐Vila, Miguel A., Matias‐Guiu, Xavier

“…Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries. Although most patients are diagnosed at early stages, 15–20% will…”
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Palbociclib has antitumour effects on Pten‐deficient endometrial neoplasias by Dosil, Maria Alba, Mirantes, Cristina, Eritja, Núria, Felip, Isidre, Navaridas, Raúl, Gatius, Sònia, Santacana, Maria, Colàs, Eva, Moiola, Cristian, Schoenenberger, Joan Antoni, Encinas, Mario, Garí, Eloi, Matias‐Guiu, Xavier, Dolcet, Xavier

“…PTEN is one of the most frequently mutated genes in human cancers. The frequency of PTEN alterations is particularly high in endometrial carcinomas. Loss of…”
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