Search Results - "Matia, Veronica"

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling by Oldrini, Barbara, Curiel-García, Álvaro, Marques, Carolina, Matia, Veronica, Uluçkan, Özge, Graña-Castro, Osvaldo, Torres-Ruiz, Raul, Rodriguez-Perales, Sandra, Huse, Jason T., Squatrito, Massimo

“…To accurately recapitulate the heterogeneity of human diseases, animal models require to recreate multiple complex genetic alterations. Here, we combine the…”
Get full text

Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers by Hydbring, Per, Wang, Yinan, Fassl, Anne, Li, Xiaoting, Matia, Veronica, Otto, Tobias, Choi, Yoon Jong, Sweeney, Katharine E., Suski, Jan M., Yin, Hao, Bogorad, Roman L., Goel, Shom, Yuzugullu, Haluk, Kauffman, Kevin J., Yang, Junghoon, Jin, Chong, Li, Yingxiang, Floris, Davide, Swanson, Richard, Ng, Kimmie, Sicinska, Ewa, Anders, Lars, Zhao, Jean J., Polyak, Kornelia, Anderson, Daniel G., Li, Cheng, Sicinski, Piotr

“…Cyclins and cyclin-dependent kinases (CDKs) are hyperactivated in numerous human tumors. To identify means of interfering with cyclins/CDKs, we performed nine…”
Get full text

Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas by Laspidea, Virginia, Puigdelloses, Montserrat, Labiano, Sara, Marrodán, Lucía, Garcia-Moure, Marc, Zalacain, Marta, Gonzalez-Huarriz, Marisol, Martínez-Vélez, Naiara, Ausejo-Mauleon, Iker, de la Nava, Daniel, Herrador-Cañete, Guillermo, Marco-Sanz, Javier, Guruceaga, Elisabeth, de Andrea, Carlos E, Villalba, María, Becher, Oren, Squatrito, Massimo, Matía, Verónica, Gállego Pérez-Larraya, Jaime, Patiño-García, Ana, Gupta, Sumit, Gomez-Manzano, Candelaria, Fueyo, Juan, Alonso, Marta M

“…Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors, and patient survival has not changed despite many therapeutic efforts,…”
Get full text

A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas by Sun, Yu, Alberta, John A, Pilarz, Catherine, Calligaris, David, Chadwick, Emily J, Ramkissoon, Shakti H, Ramkissoon, Lori A, Garcia, Veronica Matia, Mazzola, Emanuele, Goumnerova, Liliana, Kane, Michael, Yao, Zhan, Kieran, Mark W, Ligon, Keith L, Hahn, William C, Garraway, Levi A, Rosen, Neal, Gray, Nathanael S, Agar, Nathalie Y, Buhrlage, Sara J, Segal, Rosalind A, Stiles, Charles D

“…Activating mutations or structural rearrangements in BRAF are identified in roughly 75% of all pediatric low-grade astrocytomas (PLGAs). However,…”
Get full text

TMOD-19. SOMATIC GENOME EDITING WITH THE RCAS-CRISPR/Cas9 SYSTEM FOR PRECISION GLIOMA MODELING by García, Álvaro Curiel, Oldrini, Barbara, Marques, Carolina, Matia, Veronica, Squatrito, Massimo

“…It has been gradually established that the vast majority of human tumors are extraordinarily heterogeneous at a genetic level. To accurately recapitulate this…”
Get full text

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity by Tacconi, Eliana MC, Lai, Xianning, Folio, Cecilia, Porru, Manuela, Zonderland, Gijs, Badie, Sophie, Michl, Johanna, Sechi, Irene, Rogier, Mélanie, Matía García, Verónica, Batra, Ankita Sati, Rueda, Oscar M, Bouwman, Peter, Jonkers, Jos, Ryan, Anderson, Reina‐San‐Martin, Bernardo, Hui, Joannie, Tang, Nelson, Bruna, Alejandra, Biroccio, Annamaria, Tarsounas, Madalena

“…Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous…”
Get full text

The mechanistic GEMMs of oncogenic histones by Lindroth, Anders M, Park, Yoon Jung, Matía, Verónica, Squatrito, Massimo

“…The last decade's progress unraveling the mutational landscape of all age groups of cancer has uncovered mutations in histones as vital contributors of…”
Get full text

LG-47TYPE II RAF INHIBITORS INHIBIT BRAF MUTATIONS AND TRUNCATED FUSIONS IN PEDIATRIC LOW-GRADE GLIOMAS by Kieran, Mark W., Sun, Yu, Pilarz, Catherine, Calligaris, David, Chadwick, Emily J., Alberta, John A., Ramkissoon, Shakti H., Ramkissoon, Lori A., Garcia, Veronica Matia, Wilkinson, Kim, Kane, Michael, Goumnerova, Liliana, Chi, Susan N., Manley, Peter, Wright, Karen D., Agar, Nathalie Y., Ligon, Keith L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Kannan, Geoffrey, Segal, Rosalind A., Garraway, Levi A., Gray, Nathanael S., Eck, Michael, Stiles, Charles D., Buhrlage, Sara J.

Get full text

BRCA 1 and BRCA 2 tumor suppressors protect against endogenous acetaldehyde toxicity by Tacconi, Eliana MC, Lai, Xianning, Folio, Cecilia, Porru, Manuela, Zonderland, Gijs, Badie, Sophie, Michl, Johanna, Sechi, Irene, Rogier, Mélanie, Matía García, Verónica, Batra, Ankita Sati, Rueda, Oscar M, Bouwman, Peter, Jonkers, Jos, Ryan, Anderson, Reina‐San‐Martin, Bernardo, Hui, Joannie, Tang, Nelson, Bruna, Alejandra, Biroccio, Annamaria, Tarsounas, Madalena

“…Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous…”
Get full text