Search Results - "Mathôt, R. A. A."
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Perioperative treatment of hemophilia A patients: blood group O patients are at risk of bleeding complications
Published in Journal of thrombosis and haemostasis (01-03-2016)“…Essentials Targeting of factor VIII values is a challenge during perioperative replacement therapy in hemophilia. This study aims to identify the extent and…”
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Analysis of current perioperative management with Haemate® P/Humate P® in von Willebrand disease: Identifying the need for personalized treatment
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01-05-2018)“…Introduction Patients with Von Willebrand disease (VWD) are regularly treated with VWF‐containing concentrates in case of acute bleeding, trauma and dental or…”
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3
Pharmacokinetic considerations and recommendations in palliative care, with focus on morphine, midazolam and haloperidol
Published in Expert opinion on drug metabolism & toxicology (02-06-2016)“…A variety of medications are used for symptom control in palliative care, such as morphine, midazolam and haloperidol. The pharmacokinetics of these drugs may…”
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4
Population pharmacokinetics of factor IX in hemophilia B patients undergoing surgery
Published in Journal of thrombosis and haemostasis (01-11-2018)“…Essentials Factor IX (FIX) dosing using body weight frequently results in under and overdosing during surgery. We aimed to establish a population…”
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Are higher antidepressant plasma concentrations associated with fall risk in older antidepressant users?
Published in European geriatric medicine (01-02-2023)“…Key summary points Aim To explore the association between antidepressant plasma concentrations and fall risk in older users. Findings An association was found…”
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The role of plasma concentrations and drug characteristics of beta‐blockers in fall risk of older persons
Published in Pharmacology research & perspectives (01-12-2023)“…Beta‐blocker usage is inconsistently associated with increased fall risk in the literature. However, due to age‐related changes and interindividual…”
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Perioperative replacement therapy in haemophilia B: An appeal to “B” more precise
Published in Haemophilia : the official journal of the World Federation of Hemophilia (01-07-2018)“…Introduction Haemophilia B is caused by a deficiency of coagulation factor IX (FIX) and characterized by bleeding in muscles and joints. In the perioperative…”
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Determinants of drug absorption in different ECMO circuits
Published in Intensive care medicine (01-12-2010)“…Purpose The aim of this in vitro study was to evaluate potential determinants of drug loss in different ECMO circuits. Methods Midazolam, morphine, fentanyl,…”
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Setting the stage for individualized therapy in hemophilia: What role can pharmacokinetics play?
Published in Blood reviews (01-07-2018)“…Replacement therapy with clotting factor concentrates (CFC) is the mainstay of treatment in hemophilia. Its widespread application has led to a dramatic…”
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10
Yondelis® (trabectedin, ET-743): the development of an anticancer agent of marine origin
Published in Anti-cancer drugs (01-08-2003)“…Yondelis (trabectedin, ET-743) is a novel antitumor agent derived from a marine source, the Caribbean tunicate Ecteinascidia turbinata. Preclinical studies…”
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In silico evaluation of limited sampling strategies for individualized dosing of extended half-life factor IX concentrates in hemophilia B patients
Published in European journal of clinical pharmacology (01-02-2022)“…Purpose Hemophilia B is a bleeding disorder, caused by a factor IX (FIX) deficiency. Recently, FIX concentrates with extended half-life (EHL) have become…”
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Impact of mucositis on oral bioavailability and systemic exposure of ciprofloxacin Gram-negative infection prophylaxis in patients with haematological malignancies
Published in Journal of antimicrobial chemotherapy (28-10-2022)“…Abstract Background Patients with haematological malignancies frequently endure neutropenia and gastrointestinal (GI)-mucositis after high-dose chemotherapy…”
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13
Population Pharmacokinetics and Pharmacodynamics of Ciprofloxacin Prophylaxis in Pediatric Acute Lymphoblastic Leukemia Patients
Published in Clinical infectious diseases (05-11-2020)“…Abstract Background Ciprofloxacin is used as antimicrobial prophylaxis in pediatric acute lymphoblastic leukemia (ALL) to decrease infections with…”
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In silico evaluation of limited blood sampling strategies for individualized recombinant factor IX prophylaxis in hemophilia B patients
Published in Journal of thrombosis and haemostasis (01-09-2017)“…Essentials Individual pharmacokinetic (PK) parameters can be obtained by limited sampling strategies (LSSs). Following 100 IU kg−1 rFIX, LSSs with 1 to 3…”
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Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR
Published in PloS one (19-07-2016)“…Hepatic drug metabolism by cytochrome P450 enzymes is altered by the nutritional status of patients. The expression of P450 enzymes is partly regulated by the…”
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Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer
Published in Annals of oncology (01-02-2003)“…Background: Pharmacokinetic study has shown that co-administration of cyclosporin A (CsA), which acts as a P-glycoprotein (P-gp) and CYP-3A blocker, resulted…”
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Effects of nutritional status on acetaminophen measurement and exposure
Published in Clinical toxicology (Philadelphia, Pa.) (02-01-2019)“…Introduction: Fasting, as well as a high-fat diet, might increase the risk on acetaminophen-induced toxicity after an acute overdose. Therefore, it has been…”
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A comparison of the acid-inhibitory effects of esomeprazole and rabeprazole in relation to pharmacokinetics and CYP2C19 polymorphism
Published in Alimentary pharmacology & therapeutics (01-04-2012)“…Summary Background Esomeprazole and rabeprazole are metabolised in the liver by means of the CYP2C19 enzyme, which has several functional genetic…”
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Tachyphylaxis and reproducibility of desmopressin response in perioperative persons with nonsevere hemophilia A: implications for clinical practice
Published in Research and practice in thrombosis and haemostasis (01-03-2024)“…Desmopressin is frequently used perioperatively in persons with nonsevere hemophilia A. However, increase in factor (F)VIII:C after desmopressin use is…”
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Feasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation
Published in Intensive care medicine (01-09-2010)“…Purpose In most extracorporeal membrane oxygenation (ECMO) centers patients are heavily sedated to prevent accidental decannulation and bleeding complications…”
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