Search Results - "Mathieu, Jacques R R"

Implementing patient derived organoids in functional precision medicine for patients with advanced colorectal cancer by Cartry, Jérôme, Bedja, Sabrina, Boilève, Alice, Mathieu, Jacques R. R., Gontran, Emilie, Annereau, Maxime, Job, Bastien, Mouawia, Ali, Mathias, Pierre, De Baère, Thierry, Italiano, Antoine, Besse, Benjamin, Sourrouille, Isabelle, Gelli, Maximiliano, Bani, Mohamed-Amine, Dartigues, Peggy, Hollebecque, Antoine, Smolenschi, Cristina, Ducreux, Michel, Malka, David, Jaulin, Fanny

“…Abstract Background Patient Derived Organoids (PDOs) emerged as the best technology to develop ex vivo tumor avatars. Whether drug testing on PDOs to identify…”
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Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing by Bessman, Nicholas J, Mathieu, Jacques R R, Renassia, Cyril, Zhou, Lei, Fung, Thomas C, Fernandez, Keith C, Austin, Christine, Moeller, Jesper B, Zumerle, Sara, Louis, Sabine, Vaulont, Sophie, Ajami, Nadim J, Sokol, Harry, Putzel, Gregory G, Arvedson, Tara, Sockolow, Robbyn E, Lakhal-Littleton, Samira, Cloonan, Suzanne M, Arora, Manish, Peyssonnaux, Carole, Sonnenberg, Gregory F

“…Bleeding and altered iron distribution occur in multiple gastrointestinal diseases, but the importance and regulation of these changes remain unclear. We found…”
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Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis by MASTROGIANNAKI, Maria, MATAK, Pavle, MATHIEU, Jacques R. R, DELGA, Stephanie, MAYEUX, Patrick, VAULONT, Sophie, PEYSSONNAUX, Carole

“…Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected. We…”
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A Subset of the Histone H3 Lysine 9 Methyltransferases Suv39h1, G9a, GLP, and SETDB1 Participate in a Multimeric Complex by Fritsch, Lauriane, Robin, Philippe, Mathieu, Jacques R.R., Souidi, Mouloud, Hinaux, Hélène, Rougeulle, Claire, Harel-Bellan, Annick, Ameyar-Zazoua, Maya, Ait-Si-Ali, Slimane

“…Lysine 9 of histone 3 (H3K9) can be mono-, di-, or trimethylated, inducing distinct effects on gene expression and chromatin compaction. H3K9 methylation can…”
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KRAS , a New Target for Precision Medicine in Colorectal Cancer? by Boilève, Alice, Smolenschi, Cristina, Lambert, Aurélien, Boige, Valérie, Delaye, Matthieu, Camilleri, Géraldine M, Tarabay, Anthony, Valéry, Marine, Fuerea, Alina, Pudlarz, Thomas, Mathieu, Jacques R R, Jaulin, Fanny, Hollebecque, Antoine, Ducreux, Michel

“…Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with significant public health concerns. This review examines the…”
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Thrombospondin-1 Triggers Cell Migration and Development of Advanced Prostate Tumors by FIRLEJ, Virginie, MATHIEU, Jacques R. R, CABON, Florence, GILBERT, Cristèle, LEMONNIER, Loïc, NAKHLE, Jessica, GALLOU-KABANI, Catherine, GUARMIT, Basma, MORIN, Aurélie, PREVARSKAYA, Natalia, DELONGCHAMPS, Nicolas Barry

“…The antitumor effects of pharmacologic inhibitors of angiogenesis are hampered in patients by the rapid development of tumor resistance, notably through…”
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Primary Colorectal Tumor Displays Differential Genomic Expression Profiles Associated with Hepatic and Peritoneal Metastases by Gelli, Maximiliano, Desterke, Christophe, Bani, Mohamed Amine, Boige, Valérie, Ferté, Charles, Dartigues, Peggy, Job, Bastien, Perkins, Geraldine, Laurent-Puig, Pierre, Goéré, Diane, Mathieu, Jacques R. R., Cartry, Jerome, Ducreux, Michel, Jaulin, Fanny

“…Background: Despite improvements in characterization of CRC heterogeneity, appropriate risk stratification tools are still lacking in clinical practice. This…”
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Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration by Gondin, Julien, Théret, Marine, Duhamel, Guillaume, Pegan, Katarina, Mathieu, Jacques R R, Peyssonnaux, Carole, Cuvellier, Sylvain, Latroche, Claire, Chazaud, Bénédicte, Bendahan, David, Mounier, Rémi

“…Besides their role in cellular responses to hypoxia, hypoxia-inducible factors (HIFs) are involved in innate immunity and also have anti-inflammatory (M2)…”
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Pulmonary Iron Homeostasis in Hepcidin Knockout Mice by Deschemin, Jean-Christophe, Mathieu, Jacques R R, Zumerle, Sara, Peyssonnaux, Carole, Vaulont, Sophie

“…Pulmonary iron excess is deleterious and contributes to a range of chronic and acute inflammatory diseases. Optimal lung iron concentration is maintained…”
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Preeclamptic Plasma Induces Transcription Modifications Involving the AP-1 Transcriptional Regulator JDP2 in Endothelial Cells by Calicchio, Rosamaria, Buffat, Christophe, Mathieu, Jacques R, Ben Salem, Nour, Mehats, Celine, Jacques, Sébastien, Hertig, Alexandre, Berkane, Nadia, Grevoul-Fresquet, Julie, Simeoni, Umberto, Peyssonnaux, Carole, Gavard, Julie, Vaiman, Daniel, Miralles, Francisco

“…Preeclampsia is a pregnancy disorder characterized by hypertension and proteinuria. In preeclampsia, the placenta releases factors into the maternal…”
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SIRNA-directed in vivo silencing of androgen receptor inhibits the growth of castration-resistant prostate carcinomas by Compagno, Daniel, Merle, Carole, Morin, Aurélie, Gilbert, Cristèle, Mathieu, Jacques R R, Bozec, Aline, Mauduit, Claire, Benahmed, Mohammed, Cabon, Florence

“…Prostate carcinomas are initially dependent on androgens, and castration or androgen antagonists inhibit their growth. After some time though, tumors become…”
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Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis by Matak, Pavle, Heinis, Mylène, Mathieu, Jacques R R, Corriden, Ross, Cuvellier, Sylvain, Delga, Stéphanie, Mounier, Rémi, Rouquette, Alexandre, Raymond, Josette, Lamarque, Dominique, Emile, Jean-François, Nizet, Victor, Touati, Eliette, Peyssonnaux, Carole

“…Helicobacter pylori infection triggers chronic inflammation of the gastric mucosa that may progress to gastric cancer. The hypoxia-inducible factors (HIFs) are…”
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CXCR4 is highly expressed at the tumor front but not in the center of prostate cancers by Delongchamps, Nicolas Barry, Beuvon, Frédéric, Mathieu, Jacques R. R., Delmas, Stéphanie, Metzger, Isabelle, Prats, Hervé, Cabon, Florence

“…Objective To evaluate the expression of CXCR4, its ligand SDF-1, β-catenin and E-cadherin throughout the local tumor microenvironment of prostate cancer…”
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Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice by Matak, Pavle, Zumerle, Sara, Mastrogiannaki, Maria, El Balkhi, Souleiman, Delga, Stephanie, Mathieu, Jacques R R, Canonne-Hergaux, François, Poupon, Joel, Sharp, Paul A, Vaulont, Sophie, Peyssonnaux, Carole

“…Iron and copper are essential trace metals, actively absorbed from the proximal gut in a regulated fashion. Depletion of either metal can lead to anemia. In…”
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Iron Regulator Hepcidin Impairs Macrophage-Dependent Cardiac Repair After Injury by Zlatanova, Ivana, Pinto, Cristina, Bonnin, Philippe, Mathieu, Jacques R.R, Bakker, Wineke, Vilar, Jose, Lemitre, Mathilde, Voehringer, David, Vaulont, Sophie, Peyssonnaux, Carole, Silvestre, Jean-Sébastien

“…BACKGROUND:Defective systemic and local iron metabolism correlates with cardiac disorders. Hepcidin, a master iron sensor, actively tunes iron trafficking. We…”
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Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence by Morin, Aurélie, Fritsch, Lauriane, Mathieu, Jacques R. R., Gilbert, Criste'le, Guarmit, Basma, Firlej, Virginie, Gallou‐Kabani, Catherine, Vieillefond, Annick, Delongchamps, Nicolas Barry, Cabon, Florence

“…ABSTRACT Markers of prostate tumor recurrence after radical prostatectomy are lacking and highly demanded. The androgen receptor (AR) is a nuclear receptor…”
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Precision medicine for KRAS wild-type pancreatic adenocarcinomas by Ben-Ammar, Imen, Rousseau, Adrien, Nicolle, Rémy, Tarabay, Anthony, Boige, Valérie, Valery, Marine, Pudlarz, Thomas, Malka, David, Gelli, Maximiliano, Fernandez-De-Sevilla, Elena, Fuerea, Alina, Tanguy, Marie-Laure, Rouleau, Etienne, Barbe, Rémy, Mathieu, Jacques R R, Jaulin, Fanny, Smolenschi, Cristina, Hollebecque, Antoine, Ducreux, Michel, Boileve, Alice

“…KRAS mutation is the most common molecular alteration in pancreatic adenocarcinoma (PDAC), and around 10% of patients harbor KRAS wild-type tumors (KRAS ). A…”
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Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype by Zumerle, Sara, Jacques Mathieu, R.R., Delga, Stéphanie, Heinis, Mylène, Viatte, Lydie, Vaulont, Sophie, Peyssonnaux, Carole

“…Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from…”
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Organoids for Functional Precision Medicine in Advanced Pancreatic Cancer by Boilève, Alice, Cartry, Jérôme, Goudarzi, Negaar, Bedja, Sabrina, Mathieu, Jacques R.R., Bani, Mohamed-Amine, Nicolle, Rémy, Mouawia, Ali, Bouyakoub, Ryme, Nicotra, Claudio, Ngo-Camus, Maud, Job, Bastien, Lipson, Karélia, Boige, Valérie, Valéry, Marine, Tarabay, Anthony, Dartigues, Peggy, Tselikas, Lambros, de Baere, Thierry, Italiano, Antoine, Cosconea, Simona, Gelli, Maximiliano, Fernandez-de-Sevilla, Elena, Annereau, Maxime, Malka, David, Smolenschi, Cristina, Ducreux, Michel, Hollebecque, Antoine, Jaulin, Fanny

“…Patient-derived organoids (PDOs) are promising tumor avatars that could enable ex vivo drug tests to personalize patients’ treatments in the frame of…”
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Patient-derived organoids identify an apico-basolateral polarity switch associated with survival in colorectal cancer by Canet-Jourdan, Charlotte, Pagès, Diane-Laure, Nguyen-Vigouroux, Clémence, Cartry, Jérôme, Zajac, Olivier, Desterke, Christophe, Lopez, Jean-Baptiste, Gutierrez-Mateyron, Emie, Signolle, Nicolas, Adam, Julien, Raingeaud, Joel, Polrot, Mélanie, Gonin, Patrick, Mathieu, Jacques R R, Souquere, Sylvie, Pierron, Gerard, Gelli, Maximiliano, Dartigues, Peggy, Ducreux, Michel, Barresi, Valeria, Jaulin, Fanny

“…The metastatic progression of cancer remains a major issue in patient treatment. Yet, the molecular and cellular mechanisms underlying this process remains…”
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