Search Results - "Mathieu, J F"

Extracellular Vesicles and Viruses: Two Intertwined Entities by Moulin, Coline, Crupi, Mathieu J F, Ilkow, Carolina S, Bell, John C, Boulton, Stephen

“…Viruses share many attributes in common with extracellular vesicles (EVs). The cellular machinery that is used for EV production, packaging of substrates and…”
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High throughput screen identifies lysosomal acid phosphatase 2 (ACP2) to regulate IFN-1 responses to potentiate oncolytic VSV∆51 activity by Wong, Boaz, Birtch, Rayanna, Bergeron, Anabel, Ng, Kristy, Maznyi, Glib, Spinelli, Marcus, Chen, Andrew, Landry, Anne, Crupi, Mathieu J. F., Arulanandam, Rozanne, Ilkow, Carolina S., Diallo, Jean-Simon

“…Strategies in genetic and pharmacological modulation of innate immunity to enhance oncolytic virotherapy (OV) efficacy are being explored. We have recently…”
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GGA3-mediated recycling of the RET receptor tyrosine kinase contributes to cell migration and invasion by Crupi, Mathieu J. F., Maritan, Sarah M., Reyes-Alvarez, Eduardo, Lian, Eric Y., Hyndman, Brandy D., Rekab, Aisha N., Moodley, Serisha, Antonescu, Costin N., Mulligan, Lois M.

“…The RET receptor tyrosine kinase plays important roles in regulating cellular proliferation, migration, and survival in the normal development of neural crest…”
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Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies by Azad, Taha, Rezaei, Reza, Singaravelu, Ragunath, Pelin, Adrian, Boulton, Stephen, Petryk, Julia, Onsu, Kemal Alper, Martin, Nikolas T., Hoskin, Victoria, Ghahremani, Mina, Marotel, Marie, Marius, Ricardo, He, Xiaohong, Crupi, Mathieu J. F., Hoang, Huy-Dung, Nik-Akhtar, Abolfazl, Ahmadi, Mahsa, Zamani, Nika Kooshki, Golshani, Ashkan, Alain, Tommy, Greer, Peter, Ardolino, Michele, Dickinson, Bryan C., Tai, Lee-Hwa, Ilkow, Carolina S., Bell, John C.

“…The large coding potential of vaccinia virus (VV) vectors is a defining feature. However, limited regulatory switches are available to control viral…”
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Concise Review: Targeting Cancer Stem Cells and Their Supporting Niche Using Oncolytic Viruses by Crupi, Mathieu J.F., Bell, John C., Singaravelu, Ragunath

“…Cancer stem cells (CSCs) have the capacity to self‐renew and differentiate to give rise to heterogenous cancer cell lineages in solid tumors. These CSC…”
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Characterization of Critical Determinants of ACE2-SARS CoV-2 RBD Interaction by Brown, Emily E F, Rezaei, Reza, Jamieson, Taylor R, Dave, Jaahnavi, Martin, Nikolas T, Singaravelu, Ragunath, Crupi, Mathieu J F, Boulton, Stephen, Tucker, Sarah, Duong, Jessie, Poutou, Joanna, Pelin, Adrian, Yasavoli-Sharahi, Hamed, Taha, Zaid, Arulanandam, Rozanne, Surendran, Abera, Ghahremani, Mina, Austin, Bradley, Matar, Chantal, Diallo, Jean-Simon, Bell, John C, Ilkow, Carolina S, Azad, Taha

“…Despite sequence similarity to SARS-CoV-1, SARS-CoV-2 has demonstrated greater widespread virulence and unique challenges to researchers aiming to study its…”
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Differential recruitment of E3 ubiquitin ligase complexes regulates RET isoform internalization by Hyndman, Brandy D, Crupi, Mathieu J F, Peng, Susan, Bone, Leslie N, Rekab, Aisha N, Lian, Eric Y, Wagner, Simona M, Antonescu, Costin N, Mulligan, Lois M

“…The RET receptor tyrosine kinase is implicated in normal development and cancer. RET is expressed as two isoforms, RET9 and RET51, with unique C-terminal tail…”
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Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy by Martin, Nikolas T, Crupi, Mathieu J F, Taha, Zaid, Poutou, Joanna, Whelan, Jack T, Vallati, Sydney, Petryk, Julia, Marius, Ricardo, Austin, Bradley, Azad, Taha, Boulanger, Mason, Burgess, Tamara, Sanders, Ilson, Victoor, Camille, Dickinson, Bryan C, Diallo, Jean-Simon, Ilkow, Carolina S, Bell, John C

“…The approval of different cytokines as anti-neoplastic agents has been challenged by dose-limiting toxicities. Although reducing dose levels affords improved…”
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Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics by Walker, Timothy J, Reyes-Alvarez, Eduardo, Hyndman, Brandy D, Sugiyama, Michael G, Oliveira, Larissa C B, Rekab, Aisha N, Crupi, Mathieu J F, Cabral-Dias, Rebecca, Guo, Qianjin, Dahia, Patricia L M, Richardson, Douglas S, Antonescu, Costin N, Mulligan, Lois M

“…Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTKs) are important regulators of signaling in normal cells that…”
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Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer by Crupi, Mathieu J. F., Taha, Zaid, Janssen, Thijs J. A., Petryk, Julia, Boulton, Stephen, Alluqmani, Nouf, Jirovec, Anna, Kassas, Omar, Khan, Sarwat T., Vallati, Sydney, Lee, Emily, Huang, Ben Zhen, Huh, Michael, Pikor, Larissa, He, Xiaohong, Marius, Ricardo, Austin, Bradley, Duong, Jessie, Pelin, Adrian, Neault, Serge, Azad, Taha, Breitbach, Caroline J., Stojdl, David F., Burgess, Michael F., McComb, Scott, Auer, Rebecca, Diallo, Jean-Simon, Ilkow, Carolina S., Bell, John Cameron

“…Colorectal cancer is the third most diagnosed cancer and the second leading cause of cancer mortality worldwide, highlighting an urgent need for new…”
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Fatty acid transport protein inhibition sensitizes breast and ovarian cancers to oncolytic virus therapy via lipid modulation of the tumor microenvironment by Surendran, Abera, Jamalkhah, Monire, Poutou, Joanna, Birtch, Rayanna, Lawson, Christine, Dave, Jaahnavi, Crupi, Mathieu J F, Mayer, Justin, Taylor, Victoria, Petryk, Julia, de Souza, Christiano Tanese, Moodie, Neil, Billingsley, Jacob Lecompte, Austin, Bradley, Cormack, Nicole, Blamey, Natalie, Rezaei, Reza, McCloskey, Curtis W, Fekete, Emily E F, Birdi, Harsimrat K, Neault, Serge, Jamieson, Taylor R, Wylie, Brenna, Tucker, Sarah, Azad, Taha, Vanderhyden, Barbara, Tai, Lee-Hwa, Bell, John C, Ilkow, Carolina S

“…Adipocytes in the tumour microenvironment are highly dynamic cells that have an established role in tumour progression, but their impact on anti-cancer therapy…”
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Luciferase-Based Biosensors in the Era of the COVID-19 Pandemic by Azad, Taha, Janse van Rensburg, Helena J, Morgan, Jessica, Rezaei, Reza, Crupi, Mathieu J. F, Chen, Rui, Ghahremani, Mina, Jamalkhah, Monire, Forbes, Nicole, Ilkow, Carolina, Bell, John C

“…Luciferase-based biosensors have a wide range of applications and assay formats, including their relatively recent use in the study of viruses. Split…”
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CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX by Whelan, Jack T, Singaravelu, Ragunath, Wang, Fuan, Pelin, Adrian, Tamming, Levi A, Pugliese, Giuseppe, Martin, Nikolas T, Crupi, Mathieu J F, Petryk, Julia, Austin, Bradley, He, Xiaohong, Marius, Ricardo, Duong, Jessie, Jones, Carter, Fekete, Emily E F, Alluqmani, Nouf, Chen, Andrew, Boulton, Stephen, Huh, Michael S, Tang, Matt Y, Taha, Zaid, Scut, Elena, Diallo, Jean-Simon, Azad, Taha, Lichty, Brian D, Ilkow, Carolina S, Bell, John C

“…Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies. In addition to their oncolytic capacity and…”
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A High-Throughput NanoBiT-Based Serological Assay Detects SARS-CoV-2 Seroconversion by Azad, Taha, Rezaei, Reza, Singaravelu, Ragunath, Jamieson, Taylor R, Crupi, Mathieu J F, Surendran, Abera, Poutou, Joanna, Taklifi, Parisa, Cowan, Juthaporn, Cameron, Donald William, Ilkow, Carolina S

“…High-throughput detection strategies for antibodies against SARS-CoV-2 in patients recovering from COVID-19, or in vaccinated individuals, are urgently…”
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Cell surface biotinylation of receptor tyrosine kinases to investigate intracellular trafficking by Crupi, Mathieu J F, Richardson, Douglas S, Mulligan, Lois M

“…Cell surface biotinylation is a biochemical approach to covalently bind membrane-impermeable biotin to the extracellular domain of membrane proteins, such as…”
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Artistic gymnastics-specific extension of the IOC 2020 consensus statement: methods for recording and reporting of epidemiological data on injury and illness in sport by Casey, Ellen, Patel, Tejal Sarika, Almeida, Joao Francisco, Binder, Jay, Bucke, Jonathan, Duffy, Kenneth, Faustin, Marcia, Iwasaki, Yasunobu, Kruse, David, Laird, Jason, Laury, Torrance, Mathieu, JF, Rigg, Josh, Tomlinson, Chris, Thomas, Cheryl, Stokes, Keith A

“…The incidence of injuries reported in artistic gymnastics varies greatly. This is partly due to inconsistencies in defining and reporting injuries in artistic…”
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Enhanced susceptibility of cancer cells to oncolytic rhabdo-virotherapy by expression of Nodamura virus protein B2 as a suppressor of RNA interference by Bastin, Donald, Aitken, Amelia S, Pelin, Adrian, Pikor, Larissa A, Crupi, Mathieu J F, Huh, Michael S, Bourgeois-Daigneault, Marie-Claude, Bell, John C, Ilkow, Carolina S

“…Antiviral responses are barriers that must be overcome for efficacy of oncolytic virotherapy. In mammalian cells, antiviral responses involve the interferon…”
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Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization by Azad, Taha, Singaravelu, Ragunath, Crupi, Mathieu J.F., Jamieson, Taylor, Dave, Jaahnavi, Brown, Emily E.F., Rezaei, Reza, Taha, Zaid, Boulton, Stephen, Martin, Nikolas T., Surendran, Abera, Poutou, Joanna, Ghahremani, Mina, Nouri, Kazem, Whelan, Jack T., Duong, Jessie, Tucker, Sarah, Diallo, Jean-Simon, Bell, John C., Ilkow, Carolina S.

“…The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization…”
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Optimal delivery of RNA interference by viral vectors for cancer therapy by Wong, Boaz, Birtch, Rayanna, Rezaei, Reza, Jamieson, Taylor, Crupi, Mathieu, Diallo, Jean-Simon, Ilkow, Carolina S.

“…In recent years, there has been a surge in the innovative modification and application of the viral vector-based gene therapy field. Significant and consistent…”
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RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinoma by Moodley, Serisha, Lian, Eric Y., Crupi, Mathieu J.F., Hyndman, Brandy D., Mulligan, Lois M.

“…•RET51 isoform interacts with scaffold protein Ezrin and Src in lung cancer cells.•RET-Src-Ezrin signaling mediates activation of RhoA and ROCK1/2.•Enhanced…”
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