Search Results - "Mathieson, Peter"

The podocyte as a target for therapies—new and old by Mathieson, Peter W.

“…The podocyte is a key target of injury in a number of renal diseases. Although some current therapies—including glucocorticosteroids and calcineurin…”
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Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx by Singh, Anurag, Ramnath, Raina D, Foster, Rebecca R, Wylie, Emma C, Fridén, Vincent, Dasgupta, Ishita, Haraldsson, Borje, Welsh, Gavin I, Mathieson, Peter W, Satchell, Simon C

“…Reactive oxygen species (ROS) play a key role in the pathogenesis of proteinuria in glomerular diseases like diabetic nephropathy. Glomerular endothelial cell…”
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Antiphospholipase A2 Receptor Antibody Titer and Subclass in Idiopathic Membranous Nephropathy by HOFSTRA, Julia M, DEBIEC, Hanna, SHORT, Colin D, PELLE, Timotheé, KLETA, Robert, MATHIESON, Peter W, RONCO, Pierre, BRENCHLEY, Paul E, WETZELS, Jack F

“…The phospholipase A(2) receptor (PLA(2)R) is the major target antigen in idiopathic membranous nephropathy. The technique for measuring antibodies against…”
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Immunosuppression for progressive membranous nephropathy: a UK randomised controlled trial by Howman, Andrew, MMath, Chapman, Tracey L, Langdon, Maria M, MSc, Ferguson, Caroline, BSc, Adu, Dwomoa, MD, Feehally, John, Prof, Gaskin, Gillian J, PhD, Jayne, David RW, MD, O'Donoghue, Donal, Prof, Boulton-Jones, Michael, FRCP, Mathieson, Peter W, Prof

“…Summary Background Membranous nephropathy leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some…”
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APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability by Lan, Xiqian, Jhaveri, Aakash, Cheng, Kang, Wen, Hongxiu, Saleem, Moin A, Mathieson, Peter W, Mikulak, Joanna, Aviram, Sharon, Malhotra, Ashwani, Skorecki, Karl, Singhal, Pravin C

“…Development of higher rates of nondiabetic glomerulosclerosis (GS) in African Americans has been attributed to two coding sequence variants (G1 and G2) in the…”
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Academic medicine should lead the way on gender equity: but it doesn’t by Mathieson, Peter W

“…[...]their conclusions show that the situation regarding gender equity, or the lack of it, is no better in those locations than it is in North America, Europe…”
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Proteinuria and Immunity — An Overstated Relationship? by Mathieson, Peter W

“…A direct effect on the podocyte, rather than on the lymphocyte, may underlie the therapeutic effect of cyclosporine in some nephropathies. A direct effect on…”
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VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy by Onions, Karen L, Gamez, Monica, Buckner, Nicola R, Baker, Siân L, Betteridge, Kai B, Desideri, Sara, Dallyn, Benjamin P, Ramnath, Raina D, Neal, Chris R, Farmer, Louise K, Mathieson, Peter W, Gnudi, Luigi, Alitalo, Kari, Bates, David O, Salmon, Andrew H J, Welsh, Gavin I, Satchell, Simon C, Foster, Rebecca R

“…Elevated levels of vascular endothelial growth factor (VEGF) A are thought to cause glomerular endothelial cell (GEnC) dysfunction and albuminuria in diabetic…”
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Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function by Welsh, Gavin I., Hale, Lorna J., Eremina, Vera, Jeansson, Marie, Maezawa, Yoshiro, Lennon, Rachel, Pons, Deborah A., Owen, Rachel J., Satchell, Simon C., Miles, Mervyn J., Caunt, Christopher J., McArdle, Craig A., Pavenstädt, Hermann, Tavaré, Jeremy M., Herzenberg, Andrew M., Kahn, C. Ronald, Mathieson, Peter W., Quaggin, Susan E., Saleem, Moin A., Coward, Richard J.M.

“…Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by albuminuria and abnormal glomerular function and is…”
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Matrix metalloproteinase 9‐mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction by Ramnath, Raina, Foster, Rebecca R., Qiu, Yan, Cope, George, Butler, Matthew J., Salmon, Andrew H., Mathieson, Peter W., Coward, Richard J., Welsh, Gavin I., Satchell, Simon C.

“…The endothelial surface glycocalyx is a hydrated mesh in which proteoglycans are prominent. It is damaged in diseases associated with elevated levels of tumor…”
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Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy by Stanescu, Horia C, Arcos-Burgos, Mauricio, Medlar, Alan, Bockenhauer, Detlef, Kottgen, Anna, Dragomirescu, Liviu, Voinescu, Catalin, Patel, Naina, Pearce, Kerra, Hubank, Mike, Stephens, Henry A F, Laundy, Valerie, Padmanabhan, Sandosh, Zawadzka, Anna, Hofstra, Julia M, Coenen, Marieke J H, den Heijer, Martin, Kiemeney, Lambertus A L M, Bacq-Daian, Delphine, Stengel, Benedicte, Powis, Stephen H, Brenchley, Paul, Feehally, John, Rees, Andrew J, Debiec, Hanna, Wetzels, Jack F M, Ronco, Pierre, Mathieson, Peter W, Kleta, Robert

“…Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the…”
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Glomerular endothelial glycocalyx constitutes a barrier to protein permeability by SINGH, Anurag, SATCHELL, Simon C, NEAL, Chris R, MCKENZIE, Edward A, TOOKE, John E, MATHIESON, Peter W

“…Glycocalyx, composed of glycoproteins including proteoglycans, coats the luminal surface of the glomerular capillaries. Human heparanase degrades heparan…”
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A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function by Roumenina, Lubka T., Frimat, Marie, Miller, Elizabeth C., Provot, Francois, Dragon-Durey, Marie-Agnes, Bordereau, Pauline, Bigot, Sylvain, Hue, Christophe, Satchell, Simon C., Mathieson, Peter W., Mousson, Christiane, Noel, Christian, Sautes-Fridman, Catherine, Halbwachs-Mecarelli, Lise, Atkinson, John P., Lionet, Arnaud, Fremeaux-Bacchi, Veronique

“…Atypical hemolytic uremic syndrome (aHUS) is a rare renal thrombotic microangiopathy commonly associated with rare genetic variants in complement system genes,…”
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Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines by Ma, Lijun, Shelness, Gregory S, Snipes, James A, Murea, Mariana, Antinozzi, Peter A, Cheng, Dongmei, Saleem, Moin A, Satchell, Simon C, Banas, Bernhard, Mathieson, Peter W, Kretzler, Matthias, Hemal, Ashok K, Rudel, Lawrence L, Petrovic, Snezana, Weckerle, Allison, Pollak, Martin R, Ross, Michael D, Parks, John S, Freedman, Barry I

“…Although APOL1 gene variants are associated with nephropathy in African Americans, little is known about APOL1 protein synthesis, uptake, and localization in…”
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Levamisole in steroid-sensitive nephrotic syndrome: usefulness in adult patients and laboratory insights into mechanisms of action via direct action on the kidney podocyte by Jiang, Lulu, Dasgupta, Ishita, Hurcombe, Jenny A, Colyer, Heather F, Mathieson, Peter W, Welsh, Gavin I

“…Minimal change nephropathy (MCN) is the third most common cause of primary nephrotic syndrome in adults. Most patients with MCN respond to corticosteroid…”
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Update on the podocyte by Mathieson, Peter W

“…PURPOSE OF REVIEWThe podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and…”
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An in vitro model of the glomerular capillary wall using electrospun collagen nanofibres in a bioartificial composite basement membrane by Slater, Sadie C, Beachley, Vince, Hayes, Thomas, Zhang, Daming, Welsh, Gavin I, Saleem, Moin A, Mathieson, Peter W, Wen, Xuejun, Su, Bo, Satchell, Simon C

“…The filtering unit of the kidney, the glomerulus, contains capillaries whose walls function as a biological sieve, the glomerular filtration barrier. This…”
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Glomerular cell cross-talk influences composition and assembly of extracellular matrix by Byron, Adam, Randles, Michael J, Humphries, Jonathan D, Mironov, Aleksandr, Hamidi, Hellyeh, Harris, Shelley, Mathieson, Peter W, Saleem, Moin A, Satchell, Simon C, Zent, Roy, Humphries, Martin J, Lennon, Rachel

“…The glomerular basement membrane (GBM) is a specialized extracellular matrix (ECM) compartment within the glomerulus that contains tissue-restricted isoforms…”
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Phospholipase A2 Receptor (PLA2R1) Sequence Variants in Idiopathic Membranous Nephropathy by COENEN, Marieke J. H, HOFSTRA, Julia M, MATHIESON, Peter W, BRENCHLEY, Paul E, KLETA, Robert, WETZELS, Jack F. M, RONCO, Pierre, DEBIEC, Hanna, STANESCU, Horia C, MEDLAR, Alan J, STENGEL, Bénédicte, BOLAND-AUGE, Anne, GROOTHUISMINK, Johanne M, BOCKENHAUER, Detlef, POWIS, Steve H

“…The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic membranous nephropathy (iMN). Our recent genome-wide association…”
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Immunosuppression for membranous nephropathy – Authors' reply by Mathieson, Peter W

“…The Kidney Disease Improving Global Outcomes guidelines were published after our trial was designed, and the dose of ciclosporin that we used was based on the…”
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