Search Results - "Mathias, Rasika"

Current insights into the genetics of food allergy by Kanchan, Kanika, Clay, Selene, Irizar, Haritz, Bunyavanich, Supinda, Mathias, Rasika A.

“…Food allergy (FA), a growing public health burden in the United States, and familial aggregation studies support strong roles for both genes and environment in…”
Get full text

Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases by Chilton, Floyd H, Dutta, Rahul, Reynolds, Lindsay M, Sergeant, Susan, Mathias, Rasika A, Seeds, Michael C

“…Dietary essential omega-6 ( -6) and omega-3 ( -3) 18 carbon (18C-) polyunsaturated fatty acids (PUFA), linoleic acid (LA) and α-linolenic acid (ALA), can be…”
Get full text

Recent progress in the genetic and epigenetic underpinnings of atopy by Baloh, Carolyn H, Mathias, Rasika A

“…In the past 2 years, there continue to be advances in our understanding of the genetic and epigenetic underpinnings of atopy pertaining to disease risk and…”
Get full text

Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases by Chilton, Floyd H, Murphy, Robert C, Wilson, Bryan A, Sergeant, Susan, Ainsworth, Hannah, Seeds, Michael C, Mathias, Rasika A

“…The "modern western" diet (MWD) has increased the onset and progression of chronic human diseases as qualitatively and quantitatively maladaptive dietary…”
Get full text

Genome partitioning of genetic variation for complex traits using common SNPs by Yang, Jian, Manolio, Teri A, Pasquale, Louis R, Boerwinkle, Eric, Caporaso, Neil, Cunningham, Julie M, de Andrade, Mariza, Feenstra, Bjarke, Feingold, Eleanor, Hayes, M Geoffrey, Hill, William G, Landi, Maria Teresa, Alonso, Alvaro, Lettre, Guillaume, Lin, Peng, Ling, Hua, Lowe, William, Mathias, Rasika A, Melbye, Mads, Pugh, Elizabeth, Cornelis, Marilyn C, Weir, Bruce S, Goddard, Michael E, Visscher, Peter M

“…Peter Visscher and colleagues report an analysis to partition the genetic variation for several complex traits onto chromosome segments and find that the…”
Get full text

Assembly of a pan-genome from deep sequencing of 910 humans of African descent by Sherman, Rachel M., Forman, Juliet, Antonescu, Valentin, Puiu, Daniela, Daya, Michelle, Rafaels, Nicholas, Boorgula, Meher Preethi, Chavan, Sameer, Vergara, Candelaria, Ortega, Victor E., Levin, Albert M., Eng, Celeste, Yazdanbakhsh, Maria, Wilson, James G., Marrugo, Javier, Lange, Leslie A., Williams, L. Keoki, Watson, Harold, Ware, Lorraine B., Olopade, Christopher O., Olopade, Olufunmilayo, Oliveira, Ricardo R., Ober, Carole, Nicolae, Dan L., Meyers, Deborah A., Mayorga, Alvaro, Knight-Madden, Jennifer, Hartert, Tina, Hansel, Nadia N., Foreman, Marilyn G., Ford, Jean G., Faruque, Mezbah U., Dunston, Georgia M., Caraballo, Luis, Burchard, Esteban G., Bleecker, Eugene R., Araujo, Maria I., Herrera-Paz, Edwin F., Campbell, Monica, Foster, Cassandra, Taub, Margaret A., Beaty, Terri H., Ruczinski, Ingo, Mathias, Rasika A., Barnes, Kathleen C., Salzberg, Steven L.

“…We used a deeply sequenced dataset of 910 individuals, all of African descent, to construct a set of DNA sequences that is present in these individuals but…”
Get full text

The importance of studying genetic ancestry in eosinophilic esophagitis by Marker, Katie M., Mathias, Rasika A., Gignoux, Christopher R.

Get full text

Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children by Akenroye, Ayobami T., Brunetti, Tonya, Romero, Karina, Daya, Michelle, Kanchan, Kanika, Shankar, Gautam, Chavan, Sameer, Preethi Boorgula, Meher, Ampleford, Elizabeth A., Fonseca, Héllen Freitas, Hawkins, Gregory A., Pitangueira Teixeira, Helena Mariana, Campbell, Monica, Rafaels, Nicholas, Winters, Alexandra, Bleecker, Eugene R., Cruz, Alvaro A., Barreto, Mauricio L., Meyers, Deborah A., Ortega, Victor E., Figueiredo, Camila A., Barnes, Kathleen C., Checkley, William, Hansel, Nadia N., Mathias, Rasika A.

“…Genetic ancestry plays a role in asthma health disparities. Our aim was to evaluate the impact of ancestry on and identify genetic variants associated with…”
Get full text

Adaptive evolution of the FADS gene cluster within Africa by Mathias, Rasika A, Fu, Wenqing, Akey, Joshua M, Ainsworth, Hannah C, Torgerson, Dara G, Ruczinski, Ingo, Sergeant, Susan, Barnes, Kathleen C, Chilton, Floyd H

“…Long chain polyunsaturated fatty acids (LC-PUFAs) are essential for brain structure, development, and function, and adequate dietary quantities of LC-PUFAs are…”
Get full text

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations by Kowalski, Madeline H, Qian, Huijun, Hou, Ziyi, Rosen, Jonathan D, Tapia, Amanda L, Shan, Yue, Jain, Deepti, Argos, Maria, Arnett, Donna K, Avery, Christy, Barnes, Kathleen C, Becker, Lewis C, Bien, Stephanie A, Bis, Joshua C, Blangero, John, Boerwinkle, Eric, Bowden, Donald W, Buyske, Steve, Cai, Jianwen, Cho, Michael H, Choi, Seung Hoan, Choquet, Hélène, Cupples, L Adrienne, Cushman, Mary, Daya, Michelle, de Vries, Paul S, Ellinor, Patrick T, Faraday, Nauder, Fornage, Myriam, Gabriel, Stacey, Ganesh, Santhi K, Graff, Misa, Gupta, Namrata, He, Jiang, Heckbert, Susan R, Hidalgo, Bertha, Hodonsky, Chani J, Irvin, Marguerite R, Johnson, Andrew D, Jorgenson, Eric, Kaplan, Robert, Kardia, Sharon L R, Kelly, Tanika N, Kooperberg, Charles, Lasky-Su, Jessica A, Loos, Ruth J F, Lubitz, Steven A, Mathias, Rasika A, McHugh, Caitlin P, Montgomery, Courtney, Moon, Jee-Young, Morrison, Alanna C, Palmer, Nicholette D, Pankratz, Nathan, Papanicolaou, George J, Peralta, Juan M, Peyser, Patricia A, Rich, Stephen S, Rotter, Jerome I, Silverman, Edwin K, Smith, Jennifer A, Smith, Nicholas L, Taylor, Kent D, Thornton, Timothy A, Tiwari, Hemant K, Tracy, Russell P, Wang, Tao, Weiss, Scott T, Weng, Lu-Chen, Wiggins, Kerri L, Wilson, James G, Yanek, Lisa R, Zöllner, Sebastian, North, Kari E, Auer, Paul L, Raffield, Laura M, Reiner, Alexander P, Li, Yun

“…Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of…”
Get full text

Telomere shortening and the transition to family caregiving in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study by Armstrong, Nicole D, Irvin, Marguerite R, Haley, William E, Blinka, Marcela D, Kamin Mukaz, Debora, Patki, Amit, Rutherford Siegel, Sue, Shalev, Idan, Durda, Peter, Mathias, Rasika A, Walston, Jeremy D, Roth, David L

“…Telomere length (TL) is widely studied as a possible biomarker for stress-related cellular aging and decreased longevity. There have been conflicting findings…”
Get full text

Omics-oriented research illustrated with the LEAP study and the OASIS bioinformatics tool by Baloh, Carolyn H., Kanchan, Kanika, Shankar, Gautam, Nepom, Gerald T., Mathias, Rasika A., Perry, James A.

Get full text

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets by Wain, Louise V, Shrine, Nick, Artigas, María Soler, Erzurumluoglu, A Mesut, Bossini-Castillo, Lara, Obeidat, Ma'en, Henry, Amanda P, Billington, Charlotte K, Rimington, Tracy L, Fenech, Anthony G, John, Catherine, Blake, Tineka, Jackson, Victoria E, Allen, Richard J, Prins, Bram P, Campbell, Archie, Porteous, David J, Jarvelin, Marjo-Riitta, Wielscher, Matthias, Hui, Jennie, Wareham, Nicholas J, Zhao, Jing Hua, Wilson, James F, Joshi, Peter K, Stubbe, Beate, Rawal, Rajesh, Schulz, Holger, Imboden, Medea, Probst-Hensch, Nicole M, Karrasch, Stefan, Gieger, Christian, Deary, Ian J, Harris, Sarah E, Marten, Jonathan, Rudan, Igor, Enroth, Stefan, Gyllensten, Ulf, Kerr, Shona M, Polasek, Ozren, Surakka, Ida, Vitart, Veronique, Hayward, Caroline, Lehtimäki, Terho, Raitakari, Olli T, Evans, David M, Henderson, A John, Pennell, Craig E, Wang, Carol A, Sly, Peter D, Wan, Emily S, Busch, Robert, Hobbs, Brian D, Litonjua, Augusto A, Sparrow, David W, Gulsvik, Amund, Bakke, Per S, Crapo, James D, Beaty, Terri H, Hansel, Nadia N, Mathias, Rasika A, Ruczinski, Ingo, Barnes, Kathleen C, Bossé, Yohan, Joubert, Philippe, van den Berge, Maarten, Brandsma, Corry-Anke, Paré, Peter D, Sin, Don D, Nickle, David C, Hao, Ke, Gottesman, Omri, Dewey, Frederick E, Bruse, Shannon E, Carey, David J, Kirchner, H Lester, Jonsson, Stefan, Thorleifsson, Gudmar, Jonsdottir, Ingileif, Gislason, Thorarinn, Stefansson, Kari, Schurmann, Claudia, Nadkarni, Girish, Bottinger, Erwin P, Loos, Ruth J F, Walters, Robin G, Chen, Zhengming, Millwood, Iona Y, Vaucher, Julien, Kurmi, Om P, Li, Liming, Hansell, Anna L, Brightling, Chris, Zeggini, Eleftheria, Cho, Michael H, Silverman, Edwin K, Sayers, Ian, Trynka, Gosia, Morris, Andrew P, Strachan, David P, Hall, Ian P

“…Louise Wain, Ian Hall, Martin Tobin and colleagues report genome-wide association analyses of lung function, identifying 43 new signals associated with one or…”
Get full text

Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial by Huffaker, Michelle F., Kanchan, Kanika, Bahnson, Henry T., Baloh, Carolyn, Lack, Gideon, Nepom, Gerald T., Mathias, Rasika A.

“…Examining the genetics of peanut allergy (PA) in the context of clinical trial interventions and outcomes provides an opportunity to not only understand…”
Get full text

Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI by Sun, Quan, Rowland, Bryce T., Chen, Jiawen, Mikhaylova, Anna V., Avery, Christy, Peters, Ulrike, Lundin, Jessica, Matise, Tara, Buyske, Steve, Tao, Ran, Mathias, Rasika A., Reiner, Alexander P., Auer, Paul L., Cox, Nancy J., Kooperberg, Charles, Thornton, Timothy A., Raffield, Laura M., Li, Yun

“…Polygenic risk scores (PRS) have shown successes in clinics, but most PRS methods focus only on participants with distinct primary continental ancestry without…”
Get full text

Telomerase mutations in smokers with severe emphysema by Stanley, Susan E, Chen, Julian J L, Podlevsky, Joshua D, Alder, Jonathan K, Hansel, Nadia N, Mathias, Rasika A, Qi, Xiaodong, Rafaels, Nicholas M, Wise, Robert A, Silverman, Edwin K, Barnes, Kathleen C, Armanios, Mary

“…Mutations in the essential telomerase genes TERT and TR cause familial pulmonary fibrosis; however, in telomerase-null mice, short telomeres predispose to…”
Get full text

DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in human liver by Howard, Timothy D, Mathias, Rasika A, Seeds, Michael C, Herrington, David M, Hixson, James E, Shimmin, Lawrence C, Hawkins, Greg A, Sellers, Matthew, Ainsworth, Hannah C, Sergeant, Susan, Miller, Leslie R, Chilton, Floyd H

“…Levels of omega-6 (n-6) and omega-3 (n-3), long chain polyunsaturated fatty acids (LcPUFAs) such as arachidonic acid (AA; 20:4, n-6), eicosapentaenoic acid…”
Get full text

Discovering metabolite quantitative trait loci in asthma using an isolated population by Johnson, Randi K., Brunetti, Tonya, Quinn, Kevin, Doenges, Katrina, Campbell, Monica, Arehart, Christopher, Taub, Margaret A., Mathias, Rasika A., Reisdorph, Nichole, Barnes, Kathleen C., Daya, Michelle

“…Integration of metabolomics with genetics may advance understanding of disease pathogenesis but has been underused in asthma genetic studies. We sought to…”
Get full text

HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy by Kanchan, Kanika, Grinek, Stepan, Bahnson, Henry T, Ruczinski, Ingo, Shankar, Gautam, Larson, David, Du Toit, George, Barnes, Kathleen C, Sampson, Hugh A, Suarez-Farinas, Mayte, Lack, Gideon, Nepom, Gerald T, Cerosaletti, Karen, Mathias, Rasika A

“…We investigated the interplay between genetics and oral peanut protein exposure in the determination of the immunological response to peanut using the targeted…”
Get full text

FADS genetic and metabolomic analyses identify the ∆5 desaturase (FADS1) step as a critical control point in the formation of biologically important lipids by Reynolds, Lindsay M., Dutta, Rahul, Seeds, Michael C., Lake, Kirsten N., Hallmark, Brian, Mathias, Rasika A., Howard, Timothy D., Chilton, Floyd H.

“…Humans have undergone intense evolutionary selection to optimize their capacity to generate necessary quantities of long chain (LC-) polyunsaturated fatty acid…”
Get full text