Search Results - "Mathias, Paulo C. F"
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1
Maternal diet, bioactive molecules, and exercising as reprogramming tools of metabolic programming
Published in European journal of nutrition (01-04-2014)“…Nutrition and lifestyle, particularly over-nutrition and lack of exercise, promote the progression and pathogenesis of obesity and metabolic diseases…”
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2
Vagus nerve contributes to metabolic syndrome in high‐fat diet‐fed young and adult rats
Published in Experimental physiology (01-01-2015)“…New Findings What is the central question of this study? Differentnerve contributes periods of life are known for their differential sensitivity to…”
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3
Insulin Oversecretion in MSG-Obese Rats is Related to Alterations in Cholinergic Muscarinic Receptor Subtypes in Pancreatic Islets
Published in Cellular physiology and biochemistry (01-01-2014)“…Background/ Aims: Impaired pancreatic beta cell function and insulin secretion/action are a link between obesity and type 2 diabetes, which are worldwide…”
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4
Impaired β-cell function in the adult offspring of rats fed a protein-restricted diet during lactation is associated with changes in muscarinic acetylcholine receptor subtypes
Published in British journal of nutrition (28-01-2014)“…Impaired pancreatic β-cell function, as observed in the cases of early nutrition disturbance, is a major hallmark of metabolic diseases arising in adulthood…”
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5
Acute Exposure to a Precursor of Advanced Glycation End Products Induces a Dual Effect on the Rat Pancreatic Islet Function
Published in International Journal of Endocrinology (01-01-2014)“…Aim. Chronic diseases are the leading cause of death worldwide. Advanced glycation end products, known as AGEs, are a major risk factor for diabetes onset and…”
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6
Swimming training reduces glucose‐amplifying pathway and cholinergic responses in islets from lean‐ and MSG‐obese rats
Published in Clinical and experimental pharmacology & physiology (01-02-2020)“…Here, we investigate the effects of exercise training on glucose‐ and cholinergic‐induced insulin secretion in pancreatic islets from obese and lean rats. Male…”
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7
Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism
Published in Biology of reproduction (09-08-2022)“…Paternal obesity predisposes offspring to metabolic dysfunction, but the underlying mechanisms remain unclear. We investigated whether this metabolic…”
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8
Resveratrol biotransformation and actions on the liver metabolism of healthy and arthritic rats
Published in Life sciences (1973) (01-12-2022)“…AIMSto investigate the effects of resveratrol on glycogen catabolism and gluconeogenesis in perfused livers of healthy and arthritic rats. The actions of…”
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Early AGEing and metabolic diseases: is perinatal exposure to glycotoxins programming for adult-life metabolic syndrome?
Published in Nutrition reviews (01-01-2021)“…Perinatal early nutritional disorders are critical for the developmental origins of health and disease. Glycotoxins, or advanced glycation end-products, and…”
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10
Maternal hypoxia developmentally programs low podocyte endowment in male, but not female offspring
Published in Anatomical record (Hoboken, N.J. : 2007) (01-10-2020)“…Fetal hypoxia is a common complication of pregnancy. We have previously reported that maternal hypoxia in late gestation in mice gives rise to male offspring…”
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11
ACETYLCHOLINESTERASE ACTIVITY CHANGES ON VISCERAL ORGANS OF VMH LESION-INDUCED OBESE RATS
Published in International journal of neuroscience (01-11-2006)“…It is accepted that the tone of the parasympathetic nervous system increases after VMH lesion, whereas the sympathetic tone decreases. To reinforce…”
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12
HPA axis and vagus nervous function are involved in impaired insulin secretion of MSG-obese rats
Published in Journal of endocrinology (01-07-2016)“…Neuroendocrine dysfunctions such as the hyperactivity of the vagus nerve and hypothalamus–pituitary–adrenal (HPA) axis greatly contribute to obesity and…”
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13
Sympathetic innervation is essential for metabolic homeostasis and pancreatic beta cell function in adult rats
Published in Molecular and cellular endocrinology (15-02-2018)“…Obesity is associated with an imbalance in the activity of the autonomic nervous system (ANS), specifically in the organs involved in energy metabolism. The…”
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14
Oral insulin improves metabolic parameters in high fat diet fed rats
Published in Anais da Academia Brasileira de Ciências (01-07-2017)“…The gut has shown to have a pivotal role on the pathophysiology of metabolic disease. Food stimulation of distal intestinal segments promotes enterohormones…”
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15
Glibenclamide treatment blocks metabolic dysfunctions and improves vagal activity in monosodium glutamate-obese male rats
Published in Endocrine (01-05-2017)“…Background/Aims Autonomic nervous system imbalance is associated with metabolic diseases, including diabetes. Glibenclamide is an antidiabetic drug that acts…”
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16
Early treatment with metformin induces resistance against tumor growth in adult rats
Published in Cancer biology & therapy (01-01-2015)“…It is known that antidiabetic drug metformin, which is used worldwide, has anti-cancer effects and can be used to prevent cancer growth. We tested the…”
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17
Protein restriction during lactation alters the autonomic nervous system control on glucose-induced insulin secretion in adult rats
Published in Nutritional neuroscience (01-02-2007)“…Involvement of autonomic nervous system (ANS) neurotransmitters on insulin secretion in rats submitted to protein malnutrition during lactation was studied…”
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18
Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity
Published in Biochemical pharmacology (15-01-2003)“…The cooperative effect of glucagon-like peptide 1 (GLP-1) and acetylcholine (ACh) was evaluated in a beta cell line model (BRIN BD11). GLP-1 (20 nM) and ACh…”
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19
A High Fat Diet during Adolescence in Male Rats Negatively Programs Reproductive and Metabolic Function Which Is Partially Ameliorated by Exercise
Published in Frontiers in physiology (02-11-2017)“…An interaction between obesity, impaired glucose metabolism and sperm function in adults has been observed but it is not known whether exposure to a diet high…”
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20
Impaired [beta]-cell function in the adult offspring of rats fed a protein-restricted diet during lactation is associated with changes in muscarinic acetylcholine receptor subtypes
Published in British journal of nutrition (28-01-2014)“…Impaired pancreatic [beta]-cell function, as observed in the cases of early nutrition disturbance, is a major hallmark of metabolic diseases arising in…”
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