Search Results - "Mathias, Kaeli M"

Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine by Howard, Thomas P, Oberlick, Elaine M, Rees, Matthew G, Arnoff, Taylor E, Pham, Minh-Tam, Brenan, Lisa, DoCarmo, Mariana, Hong, Andrew L, Kugener, Guillaume, Chou, Hsien-Chao, Drosos, Yiannis, Mathias, Kaeli M, Ramos, Pilar, Seashore-Ludlow, Brinton, Giacomelli, Andrew O, Wang, Xiaofeng, Freeman, 3rd, Burgess B, Blankenship, Kaley, Hoffmann, Lauren, Tiv, Hong L, Gokhale, Prafulla C, Johannessen, Cory M, Stewart, Elizabeth A, Schreiber, Stuart L, Hahn, William C, Roberts, Charles W M

“…Rhabdoid tumors are devastating pediatric cancers in need of improved therapies. We sought to identify small molecules that exhibit and efficacy against…”
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Dysregulation of transcriptional condensates in human disease: mechanisms, biological functions, and open questions by Mathias, Kaeli M, Liu, Yiman, Wan, Liling

“…Precise gene expression, crucial for normal development and health, depends on the co-ordinated assembly and function of various factors within the crowded…”
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Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer by Song, Lele, Yao, Xinyi, Li, Hangpeng, Peng, Bo, Boka, Alan P., Liu, Yiman, Chen, Guochao, Liu, Zhenyang, Mathias, Kaeli M., Xia, Lingbo, Li, Qinglan, Mir, Mustafa, Li, Yuanyuan, Li, Haitao, Wan, Liling

“…Growing evidence suggests prevalence of transcriptional condensates on chromatin, yet their mechanisms of formation and functional significance remain largely…”
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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition by Drosos, Yiannis, Myers, Jacquelyn A., Xu, Beisi, Mathias, Kaeli M., Beane, Emma C., Radko-Juettner, Sandi, Mobley, Robert J., Larsen, Margaret E., Piccioni, Federica, Ma, Xiaotu, Low, Jonathan, Hansen, Baranda S., Peters, Samuel T., Bhanu, Natarajan V., Dhanda, Sandeep K., Chen, Taosheng, Upadhyaya, Santhosh A., Pruett-Miller, Shondra M., Root, David E., Garcia, Benjamin A., Partridge, Janet F., Roberts, Charles W.M.

“…Disruption of antagonism between SWI/SNF chromatin remodelers and polycomb repressor complexes drives the formation of numerous cancer types. Recently, an…”
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Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression by Liu, Yiman, Li, Qinglan, Song, Lele, Gong, Chujie, Tang, Sylvia, Budinich, Krista A, Vanderbeck, Ashley, Mathias, Kaeli M, Wertheim, Gerald B, Nguyen, Son C, Outen, Riley, Joyce, Eric F, Maillard, Ivan, Wan, Liling

“…Gain-of-function mutations in the histone acetylation "reader" eleven-nineteen-leukemia (ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known…”
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