Body surface area and body weight predict total liver volume in Western adults

Computed tomography (CT) is used increasingly to measure liver volume in patients undergoing evaluation for transplantation or resection. This study is designed to determine a formula predicting total liver volume (TLV) based on body surface area (BSA) or body weight in Western adults. TLV was measu...

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Bibliographic Details
Published in:	Liver transplantation Vol. 8; no. 3; pp. 233 - 240
Main Authors:	Vauthey, Jean-Nicolas, Abdalla, Eddie K., Doherty, Dorota A., Gertsch, Philippe, Fenstermacher, Marc J., Loyer, Evelyne M., Lerut, Jan, Materne, Roland, Wang, Xuemei, Encarnacion, Arthur, Herron, Delise, Mathey, Christian, Ferrari, Giovanni, Charnsangavej, Chuslip, Do, Kim-Anh, Denys, Alban
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA Elsevier Inc 01-03-2002 W.B. Saunders
Subjects:	Adult Body Surface Area Body Weight Forecasting Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Liver - anatomy & histology Liver - diagnostic imaging Middle Aged Models, Anatomic Organ Size Regression Analysis Tomography, X-Ray Computed Western World
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Summary:	Computed tomography (CT) is used increasingly to measure liver volume in patients undergoing evaluation for transplantation or resection. This study is designed to determine a formula predicting total liver volume (TLV) based on body surface area (BSA) or body weight in Western adults. TLV was measured in 292 patients from four Western centers. Liver volumes were calculated from helical computed tomographic scans obtained for conditions unrelated to the hepatobiliary system. BSA was calculated based on height and weight. Each center used a different established method of three-dimensional volume reconstruction. Using regression analysis, measurements were compared, and formulas correlating BSA or body weight to TLV were established. A linear regression formula to estimate TLV based on BSA was obtained: TLV = [minus ]794.41 + 1,267.28 [times ] BSA (square meters; r2 = 0.46; P [lt ] .0001). A formula based on patient weight also was derived: TLV = 191.80 + 18.51 [times ] weight (kilograms; r2 = 0.49; P [lt ] .0001). The newly derived TLV formula based on BSA was compared with previously reported formulas. The application of a formula obtained from healthy Japanese individuals underestimated TLV. Two formulas derived from autopsy data for Western populations were similar to the newly derived BSA formula, with a slight overestimation of TLV. In conclusion, hepatic three-dimensional volume reconstruction based on helical CT predicts TLV based on BSA or body weight. The new formulas derived from this correlation should contribute to the estimation of TLV before liver transplantation or major hepatic resection. (Liver Transpl 2002;8:233-240.)
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1527-6465 1527-6473
DOI:	10.1053/jlts.2002.31654