Search Results - "Mathews Griner, Lesley A"

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells by Griner, Lesley A. Mathews, Guha, Rajarshi, Shinn, Paul, Young, Ryan M., Keller, Jonathan M., Liu, Dongbo, Goldlust, Ian S., Yasgar, Adam, McKnight, Crystal, Boxer, Matthew B., Duveau, Damien Y., Jiang, Jian-Kang, Michael, Sam, Mierzwa, Tim, Huang, Wenwei, Walsh, Martin J., Mott, Bryan T., Patel, Paresma, Leister, William, Maloney, David J., Leclair, Christopher A., Rai, Ganesha, Jadhav, Ajit, Peyser, Brian D., Austin, Christopher P., Martin, Scott E., Simeonov, Anton, Ferrer, Marc, Staudt, Louis M., Thomas, Craig J.

“…The clinical development of drug combinations is typically achieved through trial-and-error or via insight gained through a detailed molecular understanding of…”
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Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2–dependent adult T-cell leukemia by Zhang, Meili, Griner, Lesley A. Mathews, Ju, Wei, Duveau, Damien Y., Guha, Rajarshi, Petrus, Michael N., Wen, Bernard, Maeda, Michiyuki, Shinn, Paul, Ferrer, Marc, Conlon, Kevin D., Bamford, Richard N., O’Shea, John J., Thomas, Craig J., Waldmann, Thomas A.

“…Adult T-cell leukemia (ATL) develops in individuals infected with human T-cell lymphotropic virus-1 (HTLV-1). Presently there is no curative therapy for ATL…”
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Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors by Ceribelli, Michele, Kelly, Priscilla N., Shaffer, Arthur L., Wright, George W., Xiao, Wenming, Yang, Yibin, Griner, Lesley A. Mathews, Guha, Rajarshi, Shinn, Paul, Keller, Jonathan M., Liu, Dongbo, Patel, Paresma R., Ferrer, Marc, Joshi, Shivangi, Nerle, Sujata, Sandy, Peter, Normant, Emmanuel, Thomas, Craig J., Staudt, Louis M.

“…In the activated B-cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), NF-κB activity is essential for viability of the malignant cells and is…”
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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF by Shao, Wenlin, Mishina, Yuji M, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G, Rivera, Stacy, Wang, Yingyun, Shen, Fang, Korn, Joshua M, Mathews Griner, Lesley A, Nishiguchi, Gisele, Rico, Alice, Tellew, John, Haling, Jacob R, Aversa, Robert, Polyakov, Valery, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P, Lees, Emma, Ramurthy, Savithri, Sellers, William R, Stuart, Darrin D

“…Resistance to the RAF inhibitor vemurafenib arises commonly in melanomas driven by the activated BRAF oncogene. Here, we report antitumor properties of RAF709,…”
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Large-scale pharmacological profiling of 3D tumor models of cancer cells by Mathews Griner, Lesley A, Zhang, Xiaohu, Guha, Rajarshi, McKnight, Crystal, Goldlust, Ian S, Lal-Nag, Madhu, Wilson, Kelli, Michael, Sam, Titus, Steve, Shinn, Paul, Thomas, Craig J, Ferrer, Marc

“…The discovery of chemotherapeutic agents for the treatment of cancer commonly uses cell proliferation assays in which cells grow as two-dimensional (2D)…”
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Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma by Bogen, Dominik, Wei, Jun S, Azorsa, David O, Ormanoglu, Pinar, Buehler, Eugen, Guha, Rajarshi, Keller, Jonathan M, Mathews Griner, Lesley A, Ferrer, Marc, Song, Young K, Liao, Hongling, Mendoza, Arnulfo, Gryder, Berkley E, Sindri, Sivasish, He, Jianbin, Wen, Xinyu, Zhang, Shile, Shern, John F, Yohe, Marielle E, Taschner-Mandl, Sabine, Shohet, Jason M, Thomas, Craig J, Martin, Scott E, Ambros, Peter F, Khan, Javed

“…Despite advances in multimodal treatment, neuroblastoma (NB) is often fatal for children with high-risk disease and many survivors need to cope with long-term…”
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A high throughput screening assay system for the identification of small molecule inhibitors of gsp by Bhattacharyya, Nisan, Hu, Xin, Chen, Catherine Z, Mathews Griner, Lesley A, Zheng, Wei, Inglese, James, Austin, Christopher P, Marugan, Juan J, Southall, Noel, Neumann, Susanne, Northup, John K, Ferrer, Marc, Collins, Michael T

“…Mis-sense mutations in the α-subunit of the G-protein, Gsα, cause fibrous dysplasia of bone/McCune-Albright syndrome. The biochemical outcome of these…”
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Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling by Li, Dandan, Miermont, Anne M, Sable, Rushikesh, Quadri, Humair S, Mathews Griner, Lesley A, Martin, Scott E, Odzorig, Taivan, De, Soumita, Ferrer, Marc, Powers, Astin S, Hewitt, Stephen M, Rudloff, Udo

“…Combinatorial molecular therapy in pancreatic ductal adenocarcinoma (PDAC) has yielded largely disappointing results in clinical testing to-date as a multitude…”
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Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis by Frankowski, Kevin J., Patnaik, Samarjit, Wang, Chen, Southall, Noel, Dutta, Dipannita, De, Soumitta, Li, Dandan, Dextras, Christopher, Lin, Yi-Han, Bryant-Connah, Marthe, Davis, Danielle, Wang, Feijun, Wachsmuth, Leah M., Shah, Pranav, Williams, Jordan, Kabir, Md, Zhu, Edward, Baljinnyam, Bolormaa, Wang, Amy, Xu, Xin, Norton, John, Ferrer, Marc, Titus, Steve, Simeonov, Anton, Zheng, Wei, Mathews Griner, Lesley A., Jadhav, Ajit, Aubé, Jeffrey, Henderson, Mark J., Rudloff, Udo, Schoenen, Frank J., Huang, Sui, Marugan, Juan J.

“…The perinucleolar compartment (PNC) is a dynamic subnuclear body found at the periphery of the nucleolus. The PNC is enriched with RNA transcripts and…”
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High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations by Mott, Bryan T., Eastman, Richard T., Guha, Rajarshi, Sherlach, Katy S., Siriwardana, Amila, Shinn, Paul, McKnight, Crystal, Michael, Sam, Lacerda-Queiroz, Norinne, Patel, Paresma R., Khine, Pwint, Sun, Hongmao, Kasbekar, Monica, Aghdam, Nima, Fontaine, Shaun D., Liu, Dongbo, Mierzwa, Tim, Mathews-Griner, Lesley A., Ferrer, Marc, Renslo, Adam R., Inglese, James, Yuan, Jing, Roepe, Paul D., Su, Xin-zhuan, Thomas, Craig J.

“…Drug resistance in Plasmodium parasites is a constant threat. Novel therapeutics, especially new drug combinations, must be identified at a faster rate. In…”
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Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype by Bian, Yansong, Teper, Yaroslav, Mathews Griner, Lesley A, Aiken, Taylor J, Shukla, Vivek, Guha, Rajarshi, Shinn, Paul, Xin, Hong-Wu, Pflicke, Holger, Powers, Astin S, Li, Dandan, Jiang, Jian-Kang, Patel, Paresma, Rogers, Steven A, Aubé, Jeffrey, Ferrer, Marc, Thomas, Craig J, Rudloff, Udo

“…Pancreatic cancer remains an incurable condition. Its progression is driven, in part, by subsets of cancer cells that evade the cytotoxic effects of…”
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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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Identification of Small Molecule Enhancers of Immunotherapy for Melanoma by Dextras, Christopher, Dashnyam, Myagmarjav, Griner, Lesley A. Mathews, Sundaresan, Janani, Chim, Bryan, Yu, Zhiya, Vodnala, Suman, Lee, Chyi-Chia Richard, Hu, Xin, Southall, Noel, Marugan, Juan J., Jadhav, Ajit, Restifo, Nicholas P., Acquavella, Nicolas, Ferrer, Marc, Singh, Anju

“…Small molecule based targeted therapies for the treatment of metastatic melanoma hold promise but responses are often not durable, and tumors frequently…”
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Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens by Guha, Rajarshi, Mathews Griner, Lesley A, Keller, Jonathan M, Zhang, Xiaohu, Fitzgerald, David, Antignani, Antonella, Pastan, Ira, Thomas, Craig J, Ferrer, Marc

“…Synthetic lethal screens are used to discover new combination treatments for cancer. In traditional high-throughput synthetic lethal screens, compounds are…”
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic by Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

“…Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling,…”
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SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy by Sarathy, Apurva, Wuebbles, Ryan D., Fontelonga, Tatiana M., Tarchione, Ashley R., Mathews Griner, Lesley A., Heredia, Dante J., Nunes, Andreia M., Duan, Suzann, Brewer, Paul D., Van Ry, Tyler, Hennig, Grant W., Gould, Thomas W., Dulcey, Andrés E., Wang, Amy, Xu, Xin, Chen, Catherine Z., Hu, Xin, Zheng, Wei, Southall, Noel, Ferrer, Marc, Marugan, Juan, Burkin, Dean J.

“…Duchenne muscular dystrophy (DMD) is a fatal muscle disease caused by mutations in the dystrophin gene, resulting in a complete loss of the dystrophin protein…”
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Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy by Wilson, Kelli M, Mathews-Griner, Lesley A, Williamson, Tara, Guha, Rajarshi, Chen, Lu, Shinn, Paul, McKnight, Crystal, Michael, Sam, Klumpp-Thomas, Carleen, Binder, Zev A, Ferrer, Marc, Gallia, Gary L, Thomas, Craig J, Riggins, Gregory J

“…Glioblastoma (GBM) is a lethal brain cancer with a median survival time of approximately 15 months following treatment. Common in vitro GBM models for drug…”
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Target deconvolution of a multikinase inhibitor with anti-metastatic properties identifies TAOK3 as a key contributor to a cancer stem cell-like phenotype by Bian, Yansong, Teper, Yaroslav, Griner, Lesley A. Mathews, Aiken, Taylor J., Shukla, Vivek, Guha, Rajarshi, Shinn, Paul, Xin, Hong-Wu, Pflicke, Holger, Powers, Astin S., Li, Dandan, Jiang, Jian-kang, Patel, Paresma, Rogers, Steven A., Aubé, Jeffrey, Ferrer, Marc, Thomas, Craig J, Rudloff, Udo

“…Pancreatic cancer remains an incurable condition. Its progression is driven, in part, by subsets of cancer cells that evade the cytotoxic effects of…”
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Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor by Stuart, Darrin D., Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G., Rivera, Stacey, Shen, Fang, Korn, Joshua, Griner, Lesley A. Mathews, Nishiguchi, Giselle, Taft, Benjamin, Wan, Lifeng, Subramanian, Sharadha, Lou, Yan, Setti, Lina, Burger, Matthew, Tamez, Victor, Rico, Alice, Aversa, Robert, Tellew, John, Haling, Jacob R., Polyakov, Valery, Lambert, Amy, Zang, Richard, Abbema, Ann Van, Hekmat-Nejad, Mohamad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P., Lees, Emma, Sellers, William R., Ramurthy, Savithri

“…Abstract The mitogen-activated protein kinase (MAPK) signaling pathway is frequently activated in human cancers due to genetic alterations that can occur at…”
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Abstract B31: Combined siRNA and small molecule screening identifies Aurora B kinase as an effective target in MYCN-driven neuroblastoma by Bogen, Dominik, Wei, Jun S., Azorsa, David O., Ormanoglu, Pinar, Buehler, Eugen, Guha, Rajarshi, Keller, Jonathan M., Griner, Lesley A. Mathews, Ferrer, Marc, Song, Young K., Liao, Hongling, Mendoza, Arnulfo, Gryder, Berkley E., Sindri, Sivasish, He, Jianbin, Wen, Xinyu, Zhang, Shile, Shern, John F., Yohe, Marielle E., Taschner-Mandl, Sabine, Shohet, Jason, Thomas, Craig J., Martin, Scott E., Ambros, Peter F., Khan, Javed

“…Abstract Despite advances in multimodal treatment, neuroblastoma (NB) is often fatal for children with high-risk disease and many survivors need to cope with…”
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