Search Results - "Mathews, Lisa R"

PIRs mediate innate myeloid cell memory to nonself MHC molecules by Dai, Hehua, Lan, Peixiang, Zhao, Daqiang, Abou-Daya, Khodor, Liu, Wentao, Chen, Wenhao, Friday, Andrew J, Williams, Amanda L, Sun, Tao, Chen, Jianjiao, Chen, Wei, Mortin-Toth, Steven, Danska, Jayne S, Wiebe, Chris, Nickerson, Peter, Li, Tengfang, Mathews, Lisa R, Turnquist, Hêth R, Nicotra, Matthew L, Gingras, Sebastien, Takayama, Eiji, Kubagawa, Hiromi, Shlomchik, Mark J, Oberbarnscheidt, Martin H, Li, Xian C, Lakkis, Fadi G

“…Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate…”
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IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease by Dwyer, Gaelen K, Mathews, Lisa R, Villegas, José A, Lucas, Anna, Gonzalez de Peredo, Anne, Blazar, Bruce R, Girard, Jean-Philippe, Poholek, Amanda C, Luther, Sanjiv A, Shlomchik, Warren, Turnquist, Hēth R

“…Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem…”
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IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells by Matta, Benjamin M, Lott, Jeremy M, Mathews, Lisa R, Liu, Quan, Rosborough, Brian R, Blazar, Bruce R, Turnquist, Hēth R

“…IL-33 is a recently characterized IL-1 family member that is proposed to function as an alarmin, or endogenous signal of cellular damage, as well as act as a…”
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Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection by Li, Tengfang, Zhang, Zhongqiang, Bartolacci, Joe G, Dwyer, Gaelen K, Liu, Quan, Mathews, Lisa R, Velayutham, Murugesan, Roessing, Anna S, Lee, Yoojin C, Dai, Helong, Shiva, Sruti, Oberbarnscheidt, Martin H, Dziki, Jenna L, Mullet, Steven J, Wendell, Stacy G, Wilkinson, James D, Webber, Steven A, Wood-Trageser, Michelle, Watkins, Simon C, Demetris, Anthony J, Hussey, George S, Badylak, Stephen F, Turnquist, Hēth R

“…Alarmins, sequestered self-molecules containing damage-associated molecular patterns, are released during tissue injury to drive innate immune cell…”
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IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury by Liu, Quan, Dwyer, Gaelen K, Zhao, Yifei, Li, Huihua, Mathews, Lisa R, Chakka, Anish Bhaswanth, Chandran, Uma R, Demetris, Jake A, Alcorn, John F, Robinson, Keven M, Ortiz, Luis A, Pitt, Bruce R, Thomson, Angus W, Fan, Ming-Hui, Billiar, Timothy R, Turnquist, Hēth R

“…Acute respiratory distress syndrome is an often fatal disease that develops after acute lung injury and trauma. How released tissue damage signals, or…”
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Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells by Rosborough, Brian R, Mathews, Lisa R, Matta, Benjamin M, Liu, Quan, Raïch-Regué, Dàlia, Thomson, Angus W, Turnquist, Hēth R

“…The Flt3-Flt3 ligand (Flt3L) pathway is critically involved in the differentiation and homeostasis of myeloid cells, including dendritic cells (DC); however,…”
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425.6: Recognition of Donor MHCI Disrupts Recipient Reparative Macrophage Differentiation by Warunek, Jordan P, Mathews, Lisa R, Oberbarnscheidt, Martin H, Lakkis, Fadi G, Turnquist, Heth R

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IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ–Dependent Apoptosis of Alloreactive CD4+ T Cells In Vitro and Reduce Lethal Graft-Versus-Host Disease by Stenger, Elizabeth O, Rosborough, Brian R, Mathews, Lisa R, Ma, Huihui, Mapara, Markus Y, Thomson, Angus W, Turnquist, Hēth R

“…Abstract Rapamycin (RAPA) inhibits the mechanistic target of rapamycin (mTOR), a crucial immune system regulator. Dendritic cells (DC) generated in RAPA…”
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Tissue-Derived IL-33 Is a Critical Local Signal That Targets Th1 Cells in the Small Intestine to Sustain Graft Versus Host Disease in the Absence of IL-12 by Dwyer, Gaelen K, Mathews, Lisa R, Lucas, Anna, Blazar, Bruce R., Shlomchik, Warren D, Turnquist, Heth

“…Background: Graft vs. host disease (GVHD) remains a major complication of allogeneic stem cell transplantation (alloSCT). To create space for donor stem cells…”
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Recipient conditioning contributes to IL-33-driven Th1 alloimmune responses following rapid ST2 upregulation on donor CD4+ T cells during lymphopenia-induced proliferation by Dwyer, Gaelen K., Mathews, Lisa R., Lucas, Anna, Blazar, Bruce R., Turnquist, Heth R.

“…Abstract IL-33 is augmented in recipient tissues by conditioning before allogeneic stem cell transplantation (alloSCT) and is a required signal to donor T cell…”
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IL-33 Augments the Capacity of Human Dendritic Cells to Expand Suppressive, but IFN-Gamma hi Regulatory T Cells by Zhao, Yifei, Zhang, Hong, Mathews, Lisa R., Thomson, Angus W., Turnquist, Heth R.

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The “Type 2” Cytokine, Interlukin-33, Generates Potent CD4 + ST2 + Tbet + Th1 Responses Independently of IL-12 under Lymphopenic Conditions by Dwyer, Gaelen K., Mathews, Lisa R., Lucas, Anna, Blazar, Bruce R., Turnquist, Heth R.

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IL-33-Driven Innate Tissue-Protective Function of ST2+ Treg Cells by Liu, Quan, Lott, Jeremy M., Mathews, Lisa R., Li, Huihua, Zhu, Qiang, Matta, Benjamin M., Delgoffe, Greg M., Fan, Ming-Hui, Turnquist, Heth R.

“…Abstract Non-lymphoid tissue-resident CD4+ Foxp3+ regulatory T (Treg) cells with the capacity to modulate non-immunological processes including organismal…”
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Flt3 ligand mediates STAT3-independent expansion, but STAT3-dependent activation of myeloid-derived suppressor cells by Rosborough, Brian R., Mathews, Lisa R., Matta, Benjamin M., Liu, Quan, Raïch-Regué, Dàlia, Thomson, Angus W., Turnquist, Hēth R.

“…The Flt3-Flt3 ligand (Flt3L) pathway is critically involved in the differentiation and homeostasis of myeloid cells, including dendritic cells (DC); however,…”
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IL-33-mediated IL-13 secretion by ST2+ Treg controls inflammation after lung injury by Liu, Quan, Dwyer, Gaelen K., Zhao, Yifei, Li, Huihua, Mathews, Lisa R., Chakka, Anish Bhaswanth, Chandran, Uma R., Demetris, Jake A., Alcorn, John F., Robinson, Keven M., Ortiz, Luis A., Pitt, Bruce, Thomson, Angus W., Fan, Ming-Hui, Billiar, Timothy R., Turnquist, Heth R.

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