Search Results - "Mathew, Sumith K."

Genetic predisposition and high exposure to colistin in the early treatment period as independent risk factors for colistin‐induced nephrotoxicity by Mathew, Sumith K., Chapla, Aaron, Venkatesan, Padmanaban, Eriyat, Vishnu, Aruldhas, Blessed Winston, Prabha, Ratna, Neely, Michael N., Rao, Shoma V., Kandasamy, Subramani, Mathew, Binu Susan

“…Colistin is known to cause nephrotoxicity due to its extensive reabsorption and accumulation in renal tubules. In vitro studies have identified the functional…”
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Cefepime Daily Exposure and the Associated Impact on the Change in Sequential Organ Failure Assessment Scores and Vasopressors Requirement in Critically Ill Patients Using Repeated-Measures Mixed-Effect Modeling by Alshaer, Mohammad H, Williams, Roy, Mousa, Mays J, Alexander, Kaitlin M, Maguigan, Kelly L, Manigaba, Kayihura, Maranchick, Nicole, Shoulders, Bethany R, Felton, Timothy W, Mathew, Sumith K, Peloquin, Charles A

“…Sepsis and septic shock are major healthcare problems that need early and appropriate management. To evaluate the association of daily cefepime…”
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Efficacy of Crushed Delayed-Release Posaconazole Tablets in Rhino-Orbito-Cerebral Mucormycosis by Manesh, Abi, Devasagayam, Emily, Bhanuprasad, Kundakarla, Mathew, Sumith K, Karthik, Rajiv, Mathew, Binu S, Varghese, George M

“…A significant proportion of patients with Rhino-orbito-cerebral mucormycosis (ROCM) develop oroantral fistulas. Due to the unclear efficacy of crushed…”
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Analytical and clinical validation of dried blood spot and volumetric absorptive microsampling for measurement of tacrolimus and creatinine after renal transplantation by Mathew, Binu Susan, Mathew, Sumith K., Aruldhas, Blessed Winston, Prabha, Ratna, Gangadharan, Naveen, David, Vinoi George, Varughese, Santosh, John, George Tharayil

“…•DBS and VAMS compared for measurement of tacrolimus and creatinine- shared extract.•Prediction equation from DBS and VAMS is validated in an independent…”
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Beta-lactam target attainment and associated outcomes in patients with bloodstream infections by Alshaer, Mohammad H., Maranchick, Nicole, Alexander, Kaitlin M., Manigaba, Kayihura, Shoulders, Bethany R., Felton, Timothy W., Mathew, Sumith K., Peloquin, Charles A.

“…•fT>4 × MIC was a significant predictor of negative blood culture on day 7•Patients who achieved 100% fT>4 × MIC had a shorter time to negative blood…”
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Using Machine Learning To Define the Impact of Beta-Lactam Early and Cumulative Target Attainment on Outcomes in Intensive Care Unit Patients with Hospital-Acquired and Ventilator-Associated Pneumonia by Alshaer, Mohammad H, Maranchick, Nicole, Bai, Chen, Maguigan, Kelly L, Shoulders, Bethany, Felton, Timothy W, Mathew, Sumith K, Mardini, Mamoun T, Peloquin, Charles A

“…Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are the most common intensive care unit (ICU) infections. We aimed to evaluate the…”
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Optimization of dosing regimens of isoniazid and rifampicin in children with tuberculosis in India by Aruldhas, Blessed Winston, Hoglund, Richard M., Ranjalkar, Jaya, Tarning, Joel, Mathew, Sumith K., Verghese, Valsan Philip, Bose, Anuradha, Mathew, Binu Susan

“…Aims Pharmacokinetic studies in the past have shown inadequate antituberculosis drug levels in children with the currently available dosing regimens. This…”
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Systemic exposure to 5‐fluorouracil and its metabolite, 5,6‐dihydrofluorouracil, and development of a limited sampling strategy for therapeutic drug management of 5‐fluorouracil in patients with gastrointestinal malignancy by Jacob, Jeana, Mathew, Sumith K., Chacko, Raju Titus, Aruldhas, Blessed Winston, Singh, Ashish, Prabha, Ratna, Mathew, Binu Susan

“…Aims 5‐Fluorouracil (5‐FU) is widely used in combination chemotherapy, and literature suggests pharmacokinetic‐guided dosing to improve clinical efficacy and…”
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Model‐Informed Rationale for Early Therapeutic Drug Monitoring of Colistin in Critically Ill Patients by Mathew, Sumith K., Rao, Shoma V., Prabha, Ratna, Neely, Michael N., Mathew, Binu Susan, Aruldhas, Blessed Winston, Veeraraghavan, Balaji, Kandasamy, Subramani

“…Adequate colistin exposure is important for microbiological clearance. This study was performed in critically ill patients >18 years old to develop a…”
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Optimal Practice for Vancomycin Therapeutic Drug Monitoring: Position Statement From the Anti-infectives Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology by Reuter, Stephanie E., Stocker, Sophie L., Alffenaar, Jan-Willem C., Baldelli, Sara, Cattaneo, Dario, Jones, Graham, Koch, Birgit C. P., Kocic, Danijela, Mathew, Sumith K., Molinaro, Mariadelfina, Neely, Michael, Sandaradura, Indy, Marriott, Deborah J. E.

“…Individualization of vancomycin dosing based on therapeutic drug monitoring (TDM) data is known to improve patient outcomes compared with fixed or empirical…”
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Stability of Vancomycin in Whole Blood by Gopalakrishnan, Abinaya Vannapatti, Sunish, Serin Cheruvathoor, Mathew, Binu S., Prabha, Ratna, Mathew, Sumith K.

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Exposure to Mycophenolic Acid and Its Clinical Response in an Indian Pediatric Population with Nephrotic Syndrome by Deepthi, R V, Arumadi, Manjusha, Eriyat, Vishnu, Mathew, Sumith K, Mathew, Binu S, Agarwal, Indira, Prabha, Ratna

“…Children with nephrotic syndrome experience many side effects and frequent relapses when treated with steroids and other drugs. Mycophenolic acid (MPA) is one…”
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Exposure to Azathioprine Metabolites and Clinical Outcome in Indian Patients with Crohn’s Disease by Prabha, Ratna, Mathew, Sumith K., Joseph, A. J., Mathew, Binu Susan

“…Aim: To determine the concentration of 6-thioguanine nucleotide (6-TGN) and 6-methylmercaptopurine (6-MMP), the interpatient variability, and the relationship…”
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Isoniazid and rifampicin concentrations in children with tuberculosis with either a daily or intermittent regimen: implications for the revised RNTCP 2012 doses in India by Ranjalkar, Jaya, Mathew, Sumith K., Verghese, Valsan Philip, Bose, Anuradha, Rose, Winsley, Gupta, Dulari, Fleming, Denise H., Mathew, Binu Susan

“…•Exposure of isoniazid and rifampicin (RIF) was not different between two anti-TB regimens in children.•77% of patients had RIF Cmax below the therapeutic…”
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Identification of DPYD variants and estimation of uracil and dihydrouracil in a healthy Indian population by Sivamani, Poornima, Eriyat, Vishnu, Mathew, Sumith K, Singh, Ashish, Aaron, Rekha, Chacko, Raju Titus, Joel, Anjana, Prabha, Ratna, Mathew, Binu Susan

“…This study aimed to identify  variants and the related but previously unexplored phenotype (plasma uracil, dihydrouracil [DHU], and the DHU-to-uracil ratio) in…”
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A Nonparametric Pharmacokinetic Approach to Determine the Optimal Dosing Regimen for 30-Minute and 3-Hour Meropenem Infusions in Critically Ill Patients by Mathew, Sumith K, Mathew, Binu S, Neely, Michael N, Naik, Girish S, Prabha, Ratna, Jacob, Gijoe G, K, Subramani, Fleming, Denise H

“…Pharmacokinetics of meropenem differ widely in the critically ill population. It is imperative to maintain meropenem concentrations above the inhibitory…”
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A Case of Septicaemic Melioidosis: Utility of Therapeutic Drug Monitoring and High-Dose Meropenem in Successful Management by Gunasekaran, Karthik, Amladi, Anushree, Mathew, Sumith K., Miraclin, T. Angel, Iyyadurai, Ramya

“…Melioidosis is an emerging infectious disease of major public health importance. We describe a patient who presented with septicaemic melioidosis with…”
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Development and validation of indocyanine green assay in human plasma using High-Performance Liquid Chromatography with PDA detector by Sumith K Mathew, Blessed Winston A, Aswathy Mathew, Jeana Jacob, Ratna Prabha, Binu Susan Mathew

“…A robust and economical assay for routine determination of indocyanine green pharmacokinetics was developed and validated using high-performance liquid…”
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Optimal Practice for Vancomycin Therapeutic Drug Monitoring: Position Statement from the Anti-Infectives Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) by Reuter, Stephanie E, Stocker, Sophie L, Alffenaar, Jan-Willem C, Baldelli, Sara, Cattaneo, Dario, Jones, Graham, Koch, Birgit CP, Kocic, Danijela, Mathew, Sumith K, Molinaro, Mariadelfina, Neely, Michael, Sandaradura, Indy, Marriott, Deborah JE

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Determination of Thiopurine S-methyltransferase Activity using Reverse-Phase High-Performance Liquid Chromatography Assay with Ultraviolet Detection: Reference Values for the Indian Population by Prabha, Ratna, Mathew, Sumith K., Joseph, A. J., Mathew, Binu Susan

“…Objective: To determine thiopurine S-methyltransferase (TPMT) activity and the range of TPMT activity values for the Indian population. Methods: An isocratic…”
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