Search Results - "Mathew, Sanjay J."

A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders by Sanacora, Gerard, Frye, Mark A, McDonald, William, Mathew, Sanjay J, Turner, Mason S, Schatzberg, Alan F, Summergrad, Paul, Nemeroff, Charles B

“…Several studies now provide evidence of ketamine hydrochloride's ability to produce rapid and robust antidepressant effects in patients with mood and anxiety…”
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The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis by Wilkinson, Samuel T, Ballard, Elizabeth D, Bloch, Michael H, Mathew, Sanjay J, Murrough, James W, Feder, Adriana, Sos, Peter, Wang, Gang, Zarate, Carlos A, Sanacora, Gerard

“…Objective:Suicide is a public health crisis with limited treatment options. The authors conducted a systematic review and individual participant data…”
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Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD) by Fava, Maurizio, Freeman, Marlene P., Flynn, Martina, Judge, Heidi, Hoeppner, Bettina B., Cusin, Cristina, Ionescu, Dawn F., Mathew, Sanjay J., Chang, Lee C., Iosifescu, Dan V., Murrough, James, Debattista, Charles, Schatzberg, Alan F., Trivedi, Madhukar H., Jha, Manish K, Sanacora, Gerard, Wilkinson, Samuel T., Papakostas, George I.

“…Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient…”
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Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial by Murrough, James W., Iosifescu, Dan V., Chang, Lee C., Al Jurdi, Rayan K., Green, Charles E., Perez, Andrew M., Iqbal, Syed, Pillemer, Sarah, Foulkes, Alexandra, Shah, Asim, Charney, Dennis S., Mathew, Sanjay J.

“…Intravenous ketamine demonstrated rapid antidepressant effects in an optimized study design, improving depression severity in 64% of treatment-resistant…”
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Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression by Price, Rebecca B, Nock, Matthew K, Charney, Dennis S, Mathew, Sanjay J

“…Background Intravenous ketamine has shown rapid antidepressant effects in early trials, making it a potentially attractive candidate for depressed patients at…”
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Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression by Murrough, James W, Perez, Andrew M, Pillemer, Sarah, Stern, Jessica, Parides, Michael K, aan het Rot, Marije, Collins, Katherine A, Mathew, Sanjay J, Charney, Dennis S, Iosifescu, Dan V

“…Background Ketamine is reported to have rapid antidepressant effects; however, there is limited understanding of the time-course of ketamine effects beyond a…”
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Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression by aan het Rot, Marije, Collins, Katherine A, Murrough, James W, Perez, Andrew M, Reich, David L, Charney, Dennis S, Mathew, Sanjay J

“…Background A single subanesthetic (intravenous) IV dose of ketamine might have rapid but transient antidepressant effects in patients with treatment-resistant…”
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EFFECTS OF KETAMINE ON EXPLICIT AND IMPLICIT SUICIDAL COGNITION: A RANDOMIZED CONTROLLED TRIAL IN TREATMENT-RESISTANT DEPRESSION by Price, Rebecca B., Iosifescu, Dan V., Murrough, James W., Chang, Lee C., Al Jurdi, Rayan K., Iqbal, Syed Z., Soleimani, Laili, Charney, Dennis S., Foulkes, Alexandra L., Mathew, Sanjay J.

“…Background Preliminary evidence suggests intravenous ketamine has rapid effects on suicidal cognition, making it an attractive candidate for depressed patients…”
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Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial by Costi, Sara, Morris, Laurel S, Kirkwood, Katherine A, Hoch, Megan, Corniquel, Morgan, Vo-Le, Brittany, Iqbal, Tabish, Chadha, Nisha, Pizzagalli, Diego A, Whitton, Alexis, Bevilacqua, Laura, Jha, Manish K, Ursu, Stefan, Swann, Alan C, Collins, Katherine A, Salas, Ramiro, Bagiella, Emilia, Parides, Michael K, Stern, Emily R, Iosifescu, Dan V, Han, Ming-Hu, Mathew, Sanjay J, Murrough, James W

“…Preclinical studies point to the KCNQ2/3 potassium channel as a novel target for the treatment of depression and anhedonia, a reduced ability to experience…”
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Identification of an optimal dose of intravenous ketamine for late-life treatment-resistant depression: a Bayesian adaptive randomization trial by Lijffijt, Marijn, Murphy, Nicholas, Iqbal, Sidra, Green, Charles E, Iqbal, Tabish, Chang, Lee C, Haile, Colin N, Hirsch, Lorna C, Ramakrishnan, Nithya, Fall, Dylan A, Swann, Alan C, Al Jurdi, Rayan K, Mathew, Sanjay J

“…Evidence supporting specific therapies for late-life treatment-resistant depression (LL-TRD) is necessary. This study used Bayesian adaptive randomization to…”
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Amino Acid Neurotransmitters Assessed by Proton Magnetic Resonance Spectroscopy: Relationship to Treatment Resistance in Major Depressive Disorder by Price, Rebecca B, Shungu, Dikoma C, Mao, Xiangling, Nestadt, Paul, Kelly, Chris, Collins, Katherine A, Murrough, James W, Charney, Dennis S, Mathew, Sanjay J

“…Background Significant alterations in γ-aminobutyric acid (GABA) and glutamate levels have been previously reported in major depressive disorder (MDD);…”
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Prefrontal Connectivity & Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment by Abdallah, Chadi G., M.D, Averill, Christopher L., B.S, Salas, Ramiro, Ph.D, Averill, Lynnette A., Ph.D, Baldwin, Philip R., Ph.D, Krystal, John H., M.D, Mathew, Sanjay J., M.D, Mathalon, Daniel H., Ph.D., M.D

“…Abstract Background Prefrontal global brain connectivity with global signal regression (GBCr) was proposed as a robust biomarker of depression, and was…”
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Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology by Shungu, Dikoma C., Weiduschat, Nora, Murrough, James W., Mao, Xiangling, Pillemer, Sarah, Dyke, Jonathan P., Medow, Marvin S., Natelson, Benjamin H., Stewart, Julian M., Mathew, Sanjay J.

“…Chronic fatigue syndrome (CFS) is a complex illness, which is often misdiagnosed as a psychiatric illness. In two previous reports, using 1H MRSI, we found…”
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Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression by Kopelman, Jared, Keller, Timothy A., Panny, Benjamin, Griffo, Angela, Degutis, Michelle, Spotts, Crystal, Cruz, Nicolas, Bell, Elizabeth, Do-Nguyen, Kevin, Wallace, Meredith L., Mathew, Sanjay J., Howland, Robert H., Price, Rebecca B.

“…Intravenous ketamine is posited to rapidly reverse depression by rapidly enhancing neuroplasticity. In human patients, we quantified gray matter…”
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Beta activity in human anterior cingulate cortex mediates reward biases by Xiao, Jiayang, Adkinson, Joshua A., Myers, John, Allawala, Anusha B., Mathura, Raissa K., Pirtle, Victoria, Najera, Ricardo, Provenza, Nicole R., Bartoli, Eleonora, Watrous, Andrew J., Oswalt, Denise, Gadot, Ron, Anand, Adrish, Shofty, Ben, Mathew, Sanjay J., Goodman, Wayne K., Pouratian, Nader, Pitkow, Xaq, Bijanki, Kelly R., Hayden, Benjamin, Sheth, Sameer A.

“…The rewards that we get from our choices and actions can have a major influence on our future behavior. Understanding how reward biasing of behavior is…”
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Cost-effectiveness and threshold analysis of deep brain stimulation vs. treatment-as-usual for treatment-resistant depression by Kabotyanski, Katherine E., Najera, Ricardo A., Banks, Garrett P., Sharma, Himanshu, Provenza, Nicole R., Hayden, Benjamin Y., Mathew, Sanjay J., Sheth, Sameer A.

“…Treatment-resistant depression (TRD) affects approximately 2.8 million people in the U.S. with estimated annual healthcare costs of $43.8 billion. Deep brain…”
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The Neurobiological Mechanisms of Generalized Anxiety Disorder and Chronic Stress by Patriquin, Michelle A., Mathew, Sanjay J.

“…Two classification systems are now at the forefront of clinical psychiatric research: (1) Diagnostic and Statistical Manual, Fifth Edition and (2) the National…”
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Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists by Krystal, John H., Mathew, Sanjay J., D’Souza, D. Cyril, Garakani, Amir, Gunduz-Bruce, Handan, Charney, Dennis S.

“…Drugs acting at metabotropic glutamate receptors (mGluRs) are among the most promising agents under development for the treatment of psychiatric disorders. The…”
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Prefrontal network engagement by deep brain stimulation in limbic hubs by Allawala, Anusha, Bijanki, Kelly R, Oswalt, Denise, Mathura, Raissa K, Adkinson, Joshua, Pirtle, Victoria, Shofty, Ben, Robinson, Meghan, Harrison, Matthew T, Mathew, Sanjay J, Goodman, Wayne K, Pouratian, Nader, Sheth, Sameer A, Borton, David A

“…Prefrontal circuits in the human brain play an important role in cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs…”
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The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes for Adult Patients with Treatment-Resistant Depression by O'Brien, Brittany, Lijffijt, Marijn, Wells, Allison, Swann, Alan C, Mathew, Sanjay J

“…Childhood maltreatment is associated with a poor treatment response to conventional antidepressants and increased risk for treatment-resistant depression…”
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