Search Results - "Mathew, Ansuja Pulickal"
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Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress
Published in Journal of nanobiotechnology (27-04-2022)“…The reactive oxygen species (ROS) and inflammation, a critical contributor to tissue damage, is well-known to be associated with various disease. The kidney is…”
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Role of Immunosuppressive Microenvironment in Acquiring Immunotolerance Post-Photothermal Therapy
Published in Journal of Korean medical science (18-11-2019)“…Nanoparticle-mediated photothermal therapy (PTT) has been well studied as a treatment for cancer. However, the therapeutic outcome of PTT is often hindered by…”
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Glycol chitosan-based tacrolimus-loaded nanomicelle therapy ameliorates lupus nephritis
Published in Journal of nanobiotechnology (17-04-2021)“…Recently, we developed hydrophobically modified glycol chitosan (HGC) nanomicelles loaded with tacrolimus (TAC) (HGC-TAC) for the targeted renal delivery of…”
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Vimentin Targeted Nano-gene Carrier for Treatment of Renal Diseases
Published in Journal of Korean medical science (20-12-2021)“…Chronic kidney disease (CKD) is a global health problem, and there is no permanent treatment for reversing kidney failure; thus, early diagnosis and effective…”
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Stimuli-Regulated Smart Polymeric Systems for Gene Therapy
Published in Polymers (24-04-2017)“…The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as…”
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Injectable hydrogels for delivering biotherapeutic molecules
Published in International journal of biological macromolecules (15-04-2018)“…[Display omitted] To date, numerous delivery systems based on either organic or inorganic material have been developed to achieve efficient and sustained…”
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Long circulating photoactivable nanomicelles with tumor localized activation and ROS triggered self-accelerating drug release for enhanced locoregional chemo-photodynamic therapy
Published in Biomaterials (01-02-2020)“…Although chemo-photodynamic therapy demonstrates promising synergetic therapeutic effect in malignant cancers, the currently available nanocarriers offer the…”
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Tumor Microenvironment-Regulating Immunosenescence-Independent Nanostimulant Synergizing with Near-Infrared Light Irradiation for Antitumor Immunity
Published in ACS applied materials & interfaces (03-02-2021)“…The combination of photothermal therapy (PTT) and toll-like receptor (TLR)-mediated immunotherapy can elicit antitumor immunity and modulate the…”
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Glycol chitosan-based renal docking biopolymeric nanomicelles for site-specific delivery of the immunosuppressant
Published in Carbohydrate polymers (01-08-2020)“…[Display omitted] •Hydrophobically modified glycol chitosan polymeric nanomicelles (HGC) loaded with hydrophobic drug tacrolimus (TAC).•Selective deposition of…”
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Inhibiting the cGAS-STING Pathway in Ulcerative Colitis with Programmable Micelles
Published in ACS nano (14-05-2024)“…Ulcerative colitis is a chronic condition in which a dysregulated immune response contributes to the acute intestinal inflammation of the colon. Current…”
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IR 780-loaded hyaluronic acid micelles for enhanced tumor-targeted photothermal therapy
Published in Carbohydrate polymers (01-02-2018)“…[Display omitted] •IR 780-loaded hyaluronic acid-based micelles (HA-IR 780) for photothermal therapy.•Intravenously administered HA-IR 780 selectively…”
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Kidney-accumulating olmesartan-loaded nanomicelles ameliorate the organ damage in a murine model of Alport syndrome
Published in International journal of pharmaceutics (01-05-2021)“…[Display omitted] ACE inhibitors or angiotensin II receptor blockers (ACEi/ARBs) have been a cornerstone of the management in kidney disease, but their use is…”
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Hyaluronan-coated Prussian blue nanoparticles relieve LPS-induced peritonitis by suppressing oxidative species generation in tissue-resident macrophages
Published in Biomaterials science (02-03-2022)“…Excessive inflammatory response during sepsis causes irreversible damage to healthy tissues and results in multi-organ failure. During infection, bacterial…”
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