Search Results - "Mathew, Anna V"

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease by Mathewson, Nathan D, Jenq, Robert, Mathew, Anna V, Koenigsknecht, Mark, Hanash, Alan, Toubai, Tomomi, Oravecz-Wilson, Katherine, Wu, Shin-Rong, Sun, Yaping, Rossi, Corinne, Fujiwara, Hideaki, Byun, Jaeman, Shono, Yusuke, Lindemans, Caroline, Calafiore, Marco, Schmidt, Thomas M, Honda, Kenya, Young, Vincent B, Pennathur, Subramaniam, van den Brink, Marcel, Reddy, Pavan

“…Irradiation to condition hosts for bone marrow transplantation leads to alterations in intestinal microbiota. Reddy and colleagues demonstrate that these…”
Get full text

Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease by Juszczak, Florian, Caron, Nathalie, Mathew, Anna V, Declèves, Anne-Emilie

“…Chronic kidney disease (CKD) is prevalent in 9.1% of the global population and is a significant public health problem associated with increased morbidity and…”
Get full text

Evidence for a link between gut microbiota and hypertension in the Dahl rat by Mell, Blair, Jala, Venkatakrishna R, Mathew, Anna V, Byun, Jaeman, Waghulde, Harshal, Zhang, Youjie, Haribabu, Bodduluri, Vijay-Kumar, Matam, Pennathur, Subramaniam, Joe, Bina

“…The gut microbiota plays a critical role in maintaining physiological homeostasis. This study was designed to evaluate whether gut microbial composition…”
Get full text

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension by Chakraborty, Saroj, Galla, Sarah, Cheng, Xi, Yeo, Ji-Youn, Mell, Blair, Singh, Vishal, Yeoh, BengSan, Saha, Piu, Mathew, Anna V., Vijay-Kumar, Matam, Joe, Bina

“…Dietary salt reduction and exercise are lifestyle modifications for salt-sensitive hypertensives. While exercise has prominent metabolic effects, salt has an…”
Get full text

AMPK Mediates the Initiation of Kidney Disease Induced by a High-Fat Diet by DECLEVES, Anne-Emilie, MATHEW, Anna V, CUNARD, Robyn, SHARMA, Kumar

“…The mechanisms underlying the association between obesity and progressive renal disease are not well understood. Exposure to a high-fat diet decreases levels…”
Get full text

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease by SHARMA, Kumar, KARL, Bethany, DIAMOND-STANIC, Maggie, LINDENMEYER, Maja T, FORSBLOM, Carol, WEI WU, IX, Joachim H, IDEKER, Trey, KOPP, Jeffrey B, NIGAM, Sanjay K, COHEN, Clemens D, GROOP, Per-Henrik, MATHEW, Anna V, BARSHOP, Bruce A, NATARAJAN, Loki, NYHAN, William L, NAVIAUX, Robert K, GANGOITI, Jon A, WASSEL, Christina L, SAITO, Rintaro, MINYA PU, SHARMA, Shoba, YOU, Young-Hyun, LIN WANG

“…Diabetic kidney disease is the leading cause of ESRD, but few biomarkers of diabetic kidney disease are available. This study used gas chromatography-mass…”
Get full text

Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study by Niewczas, Monika A, Sirich, Tammy L, Mathew, Anna V, Skupien, Jan, Mohney, Robert P, Warram, James H, Smiles, Adam, Huang, Xiaoping, Walker, Walker, Byun, Jaeman, Karoly, Edward D, Kensicki, Elizabeth M, Berry, Gerard T, Bonventre, Joseph V, Pennathur, Subramaniam, Meyer, Timothy W, Krolewski, Andrzej S

“…Here we studied plasma metabolomic profiles as determinants of progression to end-stage renal disease (ESRD) in patients with type 2 diabetes (T2D). This…”
Get more information

Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients by Jadoon, Adil, Mathew, Anna V, Byun, Jaeman, Gadegbeku, Crystal A, Gipson, Debbie S, Afshinnia, Farsad, Pennathur, Subramaniam

“…The gut microbiota is altered in patients with chronic kidney disease (CKD), and cardiovascular risk increases with progressive CKD. This study examined the…”
Get more information

Altered HDL proteome predicts incident CVD in chronic kidney disease patients by Shao, Baohai, Mathew, Anna V., Thornock, Carissa, Pennathur, Subramaniam, Kretzler, Matthias, Gipson, Debbie, Bitzer, Markus, Gadegbeku, Crystal, Bellovich, Keith, Bhat, Zeenat, Massengill, Susan, Perumal, Kalyani

“…Patients with chronic kidney disease (CKD) are at high risk for CVD. However, traditional lipid risk factors, including low HDL levels, cannot completely…”
Get full text

Obesity related kidney disease by Mathew, Anna V, Okada, Shinichi, Sharma, Kumar

“…Obesity is a risk factor for both de novo disease and as a complication of existing chronic kidney disease. Obesity related disease is characterized by…”
Get more information

Autophagy Deficiency by Hepatic FIP200 Deletion Uncouples Steatosis From Liver Injury in NAFLD by Ma, Di, Molusky, Matthew M, Song, Jianrui, Hu, Chun-Rui, Fang, Fang, Rui, Crystal, Mathew, Anna V, Pennathur, Subramaniam, Liu, Fei, Cheng, Ji-Xin, Guan, Jun-Lin, Lin, Jiandie D

“…Nonalcoholic fatty liver disease is a metabolic disorder commonly associated with obesity. A subset of nonalcoholic fatty liver disease patients further…”
Get full text

Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits by Zhang, Jifeng, Niimi, Manabu, Yang, Dongshan, Liang, Jingyan, Xu, Jie, Kimura, Tokuhide, Mathew, Anna V, Guo, Yanhong, Fan, Yanbo, Zhu, Tianqing, Song, Jun, Ackermann, Rose, Koike, Yui, Schwendeman, Anna, Lai, Liangxue, Pennathur, Subramaniam, Garcia-Barrio, Minerva, Fan, Jianglin, Chen, Y Eugene

“…CETP (cholesteryl ester transfer protein) plays an important role in lipoprotein metabolism; however, whether inhibition of CETP activity can prevent…”
Get full text

AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice by Declèves, Anne-Emilie, Mathew, Anna V., Armando, Aaron M., Han, Xianlin, Dennis, Edward A., Quehenberger, Oswald, Sharma, Kumar

“…High-fat diet (HFD) causes renal lipotoxicity that is ameliorated with AMP-activated protein kinase (AMPK) activation. Although bioactive eicosanoids increase…”
Get full text

Altered Metabolic Profile With Sodium-Restricted Dietary Approaches to Stop Hypertension Diet in Hypertensive Heart Failure With Preserved Ejection Fraction by Mathew, Anna V., MBBS, Seymour, E. Mitchell, PhD, Byun, Jaeman, PhD, Pennathur, Subramaniam, MBBS, Hummel, Scott L., MD, MS

“…Abstract Background Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized as a distinct entity with unique pathophysiology. In the…”
Get full text

Apolipoprotein A-1 mimetic peptide 4F promotes endothelial repairing and compromises reendothelialization impaired by oxidized HDL through SR-B1 by He, Dan, Zhao, Mingming, Wu, Congying, Zhang, Wenjing, Niu, Chenguang, Yu, Baoqi, Jin, Jingru, Ji, Liang, Willard, Belinda, Mathew, Anna V., Chen, Y. Eugene, Pennathur, Subramaniam, Yin, Huiyong, He, Yuan, Pan, Bing, Zheng, Lemin

“…Disruption of endothelial monolayer integrity is the primary instigating factor for many cardiovascular diseases. High density lipoprotein (HDL) oxidized by…”
Get full text

Metabolic Signature of CKD: The Search Continues by Mathew, Anna V., MBBS, Pennathur, Subramaniam, MBBS

Get full text

Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial composition by Toubai, Tomomi, Fujiwara, Hideaki, Rossi, Corinne, Riwes, Mary, Tamaki, Hiroya, Zajac, Cynthia, Liu, Chen, Mathew, Anna V., Byun, Jaeman, Oravecz-Wilson, Katherine, Matsuda, Ikuo, Sun, Yaping, Peltier, Daniel, Wu, Julia, Chen, Jiachen, Seregin, Sergey, Henig, Israel, Kim, Stephanie, Brabbs, Stuart, Pennathur, Subramaniam, Chen, Grace, Reddy, Pavan

“…Host NOD-like receptor family pyrin domain-containing 6 (NLRP6) regulates innate immune responses and gastrointestinal homeostasis. Its protective role in…”
Get full text

The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus by Tong, Xunliang, Lv, Pu, Mathew, Anna V, Liu, Donghui, Niu, Chenguang, Wang, Yan, Ji, Liang, Li, Jizhao, Fu, Zhiwei, Pan, Bing, Pennathur, Subramaniam, Zheng, Lemin, Huang, Yining

“…Glycation of high-density lipoprotein (HDL) decreases its ability to induce cyclooxygenase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in…”
Get full text

High density lipoprotein promotes proliferation of adipose-derived stem cells via S1P1 receptor and Akt, ERK1/2 signal pathways by Shen, Haitao, Zhou, Enchen, Wei, Xiujing, Fu, Zhiwei, Niu, Chenguang, Li, Yang, Pan, Bing, Mathew, Anna V, Wang, Xu, Pennathur, Subramaniam, Zheng, Lemin, Wang, Yongyu

“…Adipose-derived stem cells (ADSC) are non-hematopoietic mesenchymal stem cells that have shown great promise in their ability to differentiate into multiple…”
Get full text

Impaired Amino Acid and TCA Metabolism and Cardiovascular Autonomic Neuropathy Progression in Type 1 Diabetes by Mathew, Anna V, Jaiswal, Mamta, Ang, Lynn, Michailidis, George, Pennathur, Subramaniam, Pop-Busui, Rodica

“…While diabetes is characterized by hyperglycemia, nutrient metabolic pathways like amino acid and tricarboxylic acid (TCA) cycle are also profoundly perturbed…”
Get full text