Search Results - "Matheson, Nicholas J"

Increased demand for NAD+ relative to ATP drives aerobic glycolysis by Luengo, Alba, Li, Zhaoqi, Gui, Dan Y., Sullivan, Lucas B., Zagorulya, Maria, Do, Brian T., Ferreira, Raphael, Naamati, Adi, Ali, Ahmed, Lewis, Caroline A., Thomas, Craig J., Spranger, Stefani, Matheson, Nicholas J., Vander Heiden, Matthew G.

“…Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is associated with proliferation across many…”
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NOTCH1 mediates a switch between two distinct secretomes during senescence by Hoare, Matthew, Ito, Yoko, Kang, Tae-Won, Weekes, Michael P., Matheson, Nicholas J., Patten, Daniel A., Shetty, Shishir, Parry, Aled J., Menon, Suraj, Salama, Rafik, Antrobus, Robin, Tomimatsu, Kosuke, Howat, William, Lehner, Paul J., Zender, Lars, Narita, Masashi

“…Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells…”
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Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells by Tchasovnikarova, Iva A., Timms, Richard T., Matheson, Nicholas J., Wals, Kim, Antrobus, Robin, Göttgens, Berthold, Dougan, Gordon, Dawson, Mark A., Lehner, Paul J.

“…Forward genetic screens in Drosophila melanogaster for modifiers of position-effect variegation have revealed the basis of much of our understanding of…”
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Neural stem cells traffic functional mitochondria via extracellular vesicles by Peruzzotti-Jametti, Luca, Bernstock, Joshua D, Willis, Cory M, Manferrari, Giulia, Rogall, Rebecca, Fernandez-Vizarra, Erika, Williamson, James C, Braga, Alice, van den Bosch, Aletta, Leonardi, Tommaso, Krzak, Grzegorz, Kittel, Ágnes, Benincá, Cristiane, Vicario, Nunzio, Tan, Sisareuth, Bastos, Carlos, Bicci, Iacopo, Iraci, Nunzio, Smith, Jayden A, Peacock, Ben, Muller, Karin H, Lehner, Paul J, Buzas, Edit Iren, Faria, Nuno, Zeviani, Massimo, Frezza, Christian, Brisson, Alain, Matheson, Nicholas J, Viscomi, Carlo, Pluchino, Stefano

“…Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous…”
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Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef by Matheson, Nicholas J., Sumner, Jonathan, Wals, Kim, Rapiteanu, Radu, Weekes, Michael P., Vigan, Raphael, Weinelt, Julia, Schindler, Michael, Antrobus, Robin, Costa, Ana S.H., Frezza, Christian, Clish, Clary B., Neil, Stuart J.D., Lehner, Paul J.

“…Critical cell surface immunoreceptors downregulated during HIV infection have previously been identified using non-systematic, candidate approaches. To gain a…”
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XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection by Gerber, Pehuén Pereyra, Donde, Maria J., Matheson, Nicholas J., Taylor, Alexander I.

“…The unprecedented emergence and spread of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, underscores the need for diagnostic and…”
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Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection by Greenwood, Edward J.D., Williamson, James C., Sienkiewicz, Agata, Naamati, Adi, Matheson, Nicholas J., Lehner, Paul J.

“…HIV-1 encodes four “accessory proteins” (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well…”
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Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade by Yam-Puc, Juan Carlos, Hosseini, Zhaleh, Horner, Emily C., Gerber, Pehuén Pereyra, Beristain-Covarrubias, Nonantzin, Hughes, Robert, Lulla, Aleksei, Rust, Maria, Boston, Rebecca, Ali, Magda, Fischer, Katrin, Simmons-Rosello, Edward, O’Reilly, Martin, Robson, Harry, Booth, Lucy H., Kahanawita, Lakmini, Correa-Noguera, Andrea, Favara, David, Ceron-Gutierrez, Lourdes, Keller, Baerbel, Craxton, Andrew, Anderson, Georgina S. F., Sun, Xiao-Ming, Elmer, Anne, Saunders, Caroline, Bermperi, Areti, Jose, Sherly, Kingston, Nathalie, Mulroney, Thomas E., Piñon, Lucia P. G., Chapman, Michael A., Grigoriadou, Sofia, MacFarlane, Marion, Willis, Anne E., Patil, Kiran R., Spencer, Sarah, Staples, Emily, Warnatz, Klaus, Buckland, Matthew S., Hollfelder, Florian, Hyvönen, Marko, Döffinger, Rainer, Parkinson, Christine, Lear, Sara, Matheson, Nicholas J., Thaventhiran, James E. D.

“…Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune…”
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Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma by Lau, Allison N, Li, Zhaoqi, Danai, Laura V, Westermark, Anna M, Darnell, Alicia M, Ferreira, Raphael, Gocheva, Vasilena, Sivanand, Sharanya, Lien, Evan C, Sapp, Kiera M, Mayers, Jared R, Biffi, Giulia, Chin, Christopher R, Davidson, Shawn M, Tuveson, David A, Jacks, Tyler, Matheson, Nicholas J, Yilmaz, Omer, Vander Heiden, Matthew G

“…Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between…”
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A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection by Gerber, Pehuén Pereyra, Duncan, Lidia M, Greenwood, Edward Jd, Marelli, Sara, Naamati, Adi, Teixeira-Silva, Ana, Crozier, Thomas Wm, Gabaev, Ildar, Zhan, Jun R, Mulroney, Thomas E, Horner, Emily C, Doffinger, Rainer, Willis, Anne E, Thaventhiran, James Ed, Protasio, Anna V, Matheson, Nicholas J

“…Efforts to define serological correlates of protection against COVID-19 have been hampered by the lack of a simple, scalable, standardised assay for SARS-CoV-2…”
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Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA Level by Friedel, Caroline C, Whisnant, Adam W, Djakovic, Lara, Rutkowski, Andrzej J, Friedl, Marie-Sophie, Kluge, Michael, Williamson, James C, Sai, Somesh, Vidal, Ramon Oliveira, Sauer, Sascha, Hennig, Thomas, Grothey, Arnhild, Milić, Andrea, Prusty, Bhupesh K, Lehner, Paul J, Matheson, Nicholas J, Erhard, Florian, Dölken, Lars

“…Herpes simplex virus 1 (HSV-1) induces a profound host shutoff during lytic infection. The virion host shutoff ( ) protein plays a key role in this process by…”
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Functional proteomic atlas of HIV infection in primary human CD4+ T cells by Naamati, Adi, Williamson, James C, Greenwood, Edward Jd, Marelli, Sara, Lehner, Paul J, Matheson, Nicholas J

“…Viruses manipulate host cells to enhance their replication, and the identification of cellular factors targeted by viruses has led to key insights into both…”
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Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants by Greenwood, Edward Jd, Matheson, Nicholas J, Wals, Kim, van den Boomen, Dick Jh, Antrobus, Robin, Williamson, James C, Lehner, Paul J

“…Viruses manipulate host factors to enhance their replication and evade cellular restriction. We used multiplex tandem mass tag (TMT)-based whole cell…”
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Efficacy of FFP3 respirators for prevention of SARS-CoV-2 infection in healthcare workers by Ferris, Mark, Ferris, Rebecca, Workman, Chris, O'Connor, Eoin, Enoch, David A, Goldesgeyme, Emma, Quinnell, Natalie, Patel, Parth, Wright, Jo, Martell, Geraldine, Moody, Christine, Shaw, Ashley, Illingworth, Christopher Jr, Matheson, Nicholas J, Weekes, Michael P

“…Respiratory protective equipment recommended in the UK for healthcare workers (HCWs) caring for patients with COVID-19 comprises a fluid-resistant surgical…”
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LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein by Shilts, Jarrod, Crozier, Thomas W M, Teixeira-Silva, Ana, Gabaev, Ildar, Gerber, Pehuén Pereyra, Greenwood, Edward J D, Watson, Samuel James, Ortmann, Brian M, Gawden-Bone, Christian M, Pauzaite, Tekle, Hoffmann, Markus, Nathan, James A, Pöhlmann, Stefan, Matheson, Nicholas J, Lehner, Paul J, Wright, Gavin J

“…The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and human host factors enable the virus to propagate infections that lead…”
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Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity by Potts, Martin, Fletcher-Etherington, Alice, Nightingale, Katie, Mescia, Federica, Bergamaschi, Laura, Calero-Nieto, Fernando J., Antrobus, Robin, Williamson, James, Parsons, Harriet, Huttlin, Edward L., Kingston, Nathalie, Göttgens, Berthold, Bradley, John R., Lehner, Paul J., Matheson, Nicholas J., Smith, Kenneth G.C., Wills, Mark R., Lyons, Paul A., Weekes, Michael P.

“…Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2…”
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Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest by Marelli, Sara, Williamson, James C, Protasio, Anna V, Naamati, Adi, Greenwood, Edward Jd, Deane, Janet E, Lehner, Paul J, Matheson, Nicholas J

“…The seminal description of the cellular restriction factor APOBEC3G and its antagonism by HIV-1 Vif has underpinned two decades of research on the host-virus…”
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How does SARS-CoV-2 cause COVID-19? by Matheson, Nicholas J, Lehner, Paul J

“…The viral receptor on human cells plays a critical role in disease progression Viruses enter cells and initiate infection by binding to their cognate cell…”
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Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID by Krishna, Benjamin A, Lim, Eleanor Y, Mactavous, Lenette, Lyons, Paul A, Doffinger, Rainer, Bradley, John R, Smith, Kenneth G C, Sinclair, John, Matheson, Nicholas J, Lehner, Paul J, Wills, Mark R, Sithole, Nyaradzai

“…There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. The diagnostic complexity of Long COVID is compounded…”
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EWI-2 Inhibits Cell-Cell Fusion at the HIV-1 Virological Presynapse by Whitaker, Emily E, Matheson, Nicholas J, Perlee, Sarah, Munson, Phillip B, Symeonides, Menelaos, Thali, Markus

“…Cell-to-cell transfer of virus particles at the Env-dependent virological synapse (VS) is a highly efficient mode of HIV-1 transmission. While cell-cell fusion…”
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