Fabrication of Polymeric Coatings with Controlled Microtopographies Using an Electrospraying Technique

Surface topography of medical implants provides an important biophysical cue on guiding cellular functions at the cell-implant interface. However, few techniques are available to produce polymeric coatings with controlled microtopographies onto surgical implants, especially onto implant devices of s...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 6; p. e0129960
Main Authors:	Guo, Qiongyu, Mather, Jason P, Yang, Pine, Boden, Mark, Mather, Patrick T
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 19-06-2015 Public Library of Science (PLoS)
Subjects:	Biocompatibility Biodegradability Biodegradation Biomedical materials Cell adhesion & migration Chemical engineering Coatings Coatings industry Droplets Drug delivery Ejection Electric fields Electrospraying Fabrication Implants Medical equipment Methods Mist Polymer coatings Polymers Polymers - chemistry Polyurethane Polyurethane resins Prostheses and Implants Stainless steel Stents Surface Properties Surgery Surgical implants Topography Transplants & implants New York United States > US
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Summary:	Surface topography of medical implants provides an important biophysical cue on guiding cellular functions at the cell-implant interface. However, few techniques are available to produce polymeric coatings with controlled microtopographies onto surgical implants, especially onto implant devices of small dimension and with complex structures such as drug-eluting stents. Therefore, the main objective of this study was to develop a new strategy to fabricate polymeric coatings using an electrospraying technique based on the uniqueness of this technique in that it can be used to produce a mist of charged droplets with a precise control of their shape and dimension. We hypothesized that this technique would allow facile manipulation of coating morphology by controlling the shape and dimension of electrosprayed droplets. More specifically, we employed the electrospraying technique to coat a layer of biodegradable polyurethane with tailored microtopographies onto commercial coronary stents. The topography of such stent coatings was modulated by controlling the ratio of round to stretched droplets or the ratio of round to crumped droplets under high electric field before deposition. The shape of electrosprayed droplets was governed by the stability of these charged droplets right after ejection or during their flight in the air. Using the electrospraying technique, we achieved conformal polymeric coatings with tailored microtopographies onto conductive surgical implants. The approach offers potential for controlling the surface topography of surgical implant devices to modulate their integration with surrounding tissues.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: QG MB PTM. Performed the experiments: QG JPM PY. Analyzed the data: QG JPM PY. Contributed reagents/materials/analysis tools: MB PTM. Wrote the paper: QG JPM MB PTM PY. Current address: Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Competing Interests: MB is an employee of Boston Scientific Corporation, whose company funded this study. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0129960