Search Results - "Matheny, Tyler"

Distinct stages in stress granule assembly and disassembly by Wheeler, Joshua R, Matheny, Tyler, Jain, Saumya, Abrisch, Robert, Parker, Roy

“…Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with…”
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RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome by Van Treeck, Briana, Protter, David S. W., Matheny, Tyler, Khong, Anthony, Link, Christopher D., Parker, Roy

“…Stress granules are higher order assemblies of nontranslating mRNAs and proteins that form when translation initiation is inhibited. Stress granules are…”
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Limited effects of m6A modification on mRNA partitioning into stress granules by Khong, Anthony, Matheny, Tyler, Huynh, Thao Ngoc, Babl, Vincent, Parker, Roy

“…The presence of the m 6 A modification in mammalian mRNAs is proposed to promote mRNA recruitment to stress granules through the interaction with YTHDF…”
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Isolation of mammalian stress granule cores for RNA-Seq analysis by Khong, Anthony, Jain, Saumya, Matheny, Tyler, Wheeler, Joshua R., Parker, Roy

“…•SG cores can be biochemically purified by successive centrifugation and immunoprecipitation.•Validation of RNA-Seq results by single molecule FISH.•Image…”
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Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression by Campbell, Amy E., Dyle, Michael C., Albanese, Roberto, Matheny, Tyler, Sudheendran, Kavitha, Cortázar, Michael A., Forman, Thomas, Fu, Rui, Gillen, Austin E., Caruthers, Marvin H., Floor, Stephen N., Calviello, Lorenzo, Jagannathan, Sujatha

“…Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination codons. NMD is thought to prevent the synthesis of toxic truncated…”
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Transcriptome-Wide Comparison of Stress Granules and P-Bodies Reveals that Translation Plays a Major Role in RNA Partitioning by Matheny, Tyler, Rao, Bhalchandra S., Parker, Roy

“…The eukaryotic cytosol contains multiple RNP granules, including P-bodies and stress granules. Three different methods have been used to describe the…”
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The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules by Khong, Anthony, Matheny, Tyler, Jain, Saumya, Mitchell, Sarah F., Wheeler, Joshua R., Parker, Roy

“…Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress granules are important in the stress response and may contribute to some…”
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RNA partitioning into stress granules is based on the summation of multiple interactions by Matheny, Tyler, Van Treeck, Briana, Huynh, Thao Ngoc, Parker, Roy

“…Stress granules (SGs) are stress-induced RNA-protein assemblies formed from a complex transcriptome of untranslating ribonucleoproteins (RNPs). Although RNAs…”
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RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs by Burke, James M., Moon, Stephanie L., Matheny, Tyler, Parker, Roy

“…In response to foreign and endogenous double-stranded RNA (dsRNA), protein kinase R (PKR) and ribonuclease L (RNase L) reprogram translation in mammalian…”
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Identification of NAD⁺ capped mRNAs in Saccharomyces cerevisiae by Walters, Robert W., Matheny, Tyler, Mizoue, Laura S., Rao, Bhalchandra S., Muhlrad, Denise, Parker, Roy

“…RNAs besides tRNA and rRNA contain chemical modifications, including the recently described 5′ nicotinamide-adenine dinucleotide (NAD⁺) RNA in bacteria…”
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Corrigendum: RNA partitioning into stress granules is based on the summation of multiple interactions by Matheny, Tyler, Van Treeck, Briana, Huynh, Thao Ngoc, Parker, Roy

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Haploinsufficiency, Dominant Negative, and Gain-of-Function Mechanisms in Epilepsy: Matching Therapeutic Approach to the Pathophysiology by Carvill, Gemma L., Matheny, Tyler, Hesselberth, Jay, Demarest, Scott

“…This review summarizes the pathogenic mechanisms that underpin the monogenic epilepsies and discusses the potential of novel precision therapeutics to treat…”
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Isolation of mammalian SG cores for RNA-Seq analysis by Khong, Anthony, Jain, Saumya, Matheny, Tyler, Wheeler, Joshua R., Parker, Roy

“…Stress granules are dynamic, conserved non-translating RNA-protein assemblies that form during cellular stress and are related to pathological aggregates in…”
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Limited effects of m 6 A modification on mRNA partitioning into stress granules by Khong, Anthony, Matheny, Tyler, Huynh, Thao Ngoc, Babl, Vincent, Parker, Roy

“…The presence of the m A modification in mammalian mRNAs is proposed to promote mRNA recruitment to stress granules through the interaction with YTHDF proteins…”
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Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS by Baron, Desiree M, Matheny, Tyler, Lin, Yen-Chen, Leszyk, John D, Kenna, Kevin, Gall, Katherine V, Santos, David P, Tischbein, Maeve, Funes, Salome, Hayward, Lawrence J, Kiskinis, Evangelos, Landers, John E, Parker, Roy, Shaffer, Scott A, Bosco, Daryl A

“…Abstract Aberrant translational repression is a feature of multiple neurodegenerative diseases. The association between disease-linked proteins and stress…”
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Composition and Dynamics of Stress Granules by Matheny, Tyler

“…Stress granules are non-membranous assemblies of RNA and protein that form during conditions in which translation initiation is limited. Stress granules are of…”
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