Search Results - "Mathad, Raveendra I."

The Major G‑Quadruplex Formed in the Human BCL‑2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution by Agrawal, Prashansa, Lin, Clement, Mathad, Raveendra I, Carver, Megan, Yang, Danzhou

“…The human BCL-2 gene contains a 39-bp GC-rich region upstream of the P1 promoter that has been shown to be critically involved in the regulation of BCL-2 gene…”
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c-MYC promoter G-quadruplex formed at the 5′-end of NHE III1 element: insights into biological relevance and parallel-stranded G-quadruplex stability by Mathad, Raveendra I., Hatzakis, Emmanuel, Dai, Jixun, Yang, Danzhou

“…We studied the structures and stabilities of G-quadruplexes formed in Myc1234, the region containing the four consecutive 5′ runs of guanines of c-MYC promoter…”
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Interpreting Experimental Data by Using Molecular Simulation Instead of Model Building by Gattin, Zrinka, Schwartz, Julian, Mathad, Raveendra I., Jaun, Bernhard, van Gunsteren, Wilfred F.

“…A proper description of the conformational equilibrium of polypeptides or proteins is essential for a correct description of their function. The conformational…”
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Solution structure of a 2:1 complex of anticancer drug XR5944 with TFF1 estrogen response element: insights into DNA recognition by a bis-intercalator by Lin, Clement, Mathad, Raveendra I., Zhang, Zhenjiang, Sidell, Neil, Yang, Danzhou

“…XR5944, a deoxyribonucleic acid (DNA) bis-intercalator with potent anticancer activity, can bind the estrogen response element (ERE) sequence to inhibit…”
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The Enantiomer of Octreotate Binds to All Five Somatostatin Receptors with Almost Equal Micromolar Affinity - A Comparison with SANDOSTATIN by Gardiner, James, Langenegger, Daniel, Hoyer, Daniel, Beck, Albert K., Mathad, Raveendra I., Seebach, Dieter

“…Octreotate (1b) is the octreotide (SANDOSTATIN®; 1a) analogue, carrying a C‐terminal CO2H (Thr) instead of the CH2OH (threoninol) group. In pursuit of our…”
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G-quadruplex structures and G-quadruplex-interactive compounds by Mathad, Raveendra I, Yang, Danzhou

“…G-quadruplexes are noncanonical secondary structures formed in DNA sequences containing consecutive runs of guanines. DNA G-quadruplexes have recently emerged…”
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Comparison of Permeation through Phosphatidylcholine Bilayers of N-Dipicolinyl-α- and -β-Oligopeptides by Gardiner, James, Thomae, Anita V., Mathad, Raveendra I., Seebach, Dieter, Krämer, Stefanie D.

“…Cell‐membrane permeation of small therapeutic peptides and peptidomimetics is a fundamental issue in pharmaceutical research. Using a Tb3+‐based permeation…”
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Intercalation of XR5944 with the estrogen response element is modulated by the tri-nucleotide spacer sequence between half-sites by Sidell, Neil, Mathad, Raveendra I., Shu, Feng-jue, Zhang, Zhenjiang, Kallen, Caleb B., Yang, Danzhou

“…► Tested binding of XR5944 with EREs containing variable tri-nucleotide spacer sequences. ► The spacer sequence significantly modulates the binding of XR5944…”
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Synthesis, and Helix or Hairpin-Turn Secondary Structures of 'Mixed' α/β-Peptides Consisting of Residues with Proteinogenic Side Chains and of 2-Amino-2-methylpropanoic Acid (Aib) by Seebach, Dieter, Jaun, Bernhard, Sebesta, Radovan, Mathad, Raveendra I., Flögel, Oliver, Limbach, Michael, Sellner, Holger, Cottens, Sylvain

“…Twelve peptides, 1–12, have been synthesized, which consist of alternating sequences of α‐ and β‐amino acid residues carrying either proteinogenic side chains…”
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NMR‐Solution Structures of Fluoro‐Substituted β ‐Peptides: A 3 14 ‐Helix and a Hairpin Turn. The First Case of a 90° OCCF Dihedral Angle in an α ‐Fluoro‐Amide Group by Mathad, Raveendra I., Jaun, Bernhard, Flögel, Oliver, Gardiner, James, Löweneck, Markus, Codée, Jeroen D. C., Seeberger, Peter H., Seebach, Dieter, Edmonds, Michael K., Graichen, Florian H. M., Abell, Andrew D.

“…Abstract To further study the preference of the antiperiplanar ( ap ) conformation in α ‐fluoro‐amide groups, two β ‐peptides, 1 and 2 , containing a (2‐F)‐ β…”
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β-Peptide Conjugates: Syntheses and CD and NMR Investigations of β/α-Chimeric Peptides, of a DPA-β-Decapeptide, and of a PEGylated β-Heptapeptide by Gardiner, James, Mathad, Raveendra I., Jaun, Berhard, Schreiber, Jürg V., Flögel, Oliver, Seebach, Dieter

“…β3‐Peptides consisting of six, seven, and ten homologated proteinogenic amino acid residues have been attached to an α‐heptapeptide (all d‐amino acid residues;…”
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c-MYC promoter G-quadruplex formed at the 5′-end of NHE III 1 element: insights into biological relevance and parallel-stranded G-quadruplex stability by Mathad, Raveendra I., Hatzakis, Emmanuel, Dai, Jixun, Yang, Danzhou

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On the Influence of Charged Side Chains on the Folding-Unfolding Equilibrium of β-Peptides: A Molecular Dynamics Simulation Study by Glättli, Alice, Daura, Xavier, Bindschädler, Pascal, Jaun, Bernhard, Mahajan, Yogesh R., Mathad, Raveendra I., Rueping, Magnus, Seebach, Dieter, van Gunsteren, Wilfred F.

“…The influence of charged side chains on the folding–unfolding equilibrium of β‐peptides was investigated by means of molecular dynamics simulations. Four…”
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Simulation of an all-beta 3-icosapeptide containing the 20 proteinogenic side chains: effect of temperature, pH, counterions, solvent, and force field on helix stability by Trzesniak, Daniel, Jaun, Bernhard, Mathad, Raveendra I, van Gunsteren, Wilfred F

“…Simulations of various beta-peptides have in the last years clarified several issues concerning peptide folding equilibria and interpretation of experimental…”
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Abstract 2445: DNA recognition by XR5944, a novel bis-intercalator and potent anticancer drug by Lin, Clement, Mathad, Raveendra I., Sidell, Neil, Yang, Danzhou

“…Abstract DNA is a major target for drugs used in cancer therapy. However, DNA interactive chemotherapeutics are limited by adverse effects due to their poor…”
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c-MYC promoter G-quadruplex formed at the 5'-end of NHE III sub(1) element: insights into biological relevance and parallel-stranded G-quadruplex stability by Mathad, Raveendra I, Hatzakis, Emmanuel, Dai, Jixun, Yang, Danzhou

“…We studied the structures and stabilities of G-quadruplexes formed in Myc1234, the region containing the four consecutive 5' runs of guanines of c-MYC promoter…”
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Note: Helix or No Helix of β-Peptides Containing β3hAla(αF) Residues? by Jaun, Bernhard, Seebach, Dieter, Mathad, Raveendra I.

“…A remote 4J(F,H) coupling (FC(α)C(O)NH) of up to 4.2 Hz in α‐fluoro amides with antiperiplanar arrangement of the CF and the CO bonds (dihedral angle…”
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Note: Helix or No Helix of β ‐Peptides Containing β 3 hAla( α F) Residues? by Jaun, Bernhard, Seebach, Dieter, Mathad, Raveendra I.

“…Abstract A remote 4 J (F,H) coupling (FC( α )C(O)NH) of up to 4.2 Hz in α ‐fluoro amides with antiperiplanar arrangement of the CF and the CO bonds…”
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Abstract LB-200: Solution structure of c-Myc G-quadruplex complex with a quindoline compound by Dai, Jixun, Carver, Megan, Mathad, Raveendra I., Hurley, Lawrence, Yang, Danzhou

“…Abstract Overexpression of the c-Myc oncogene is associated with a broad spectrum of human cancers. Targeting transcriptional control of c-Myc represents an…”
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Abstract 4514: NMR study of XR5944 interaction with diverse estrogen response elements (EREs) by Mathad, Raveendra I., Zhang, Zhenjiang, Shu, Feng-jue, Chen, Xi, Carver, Megan, Kallen, Caleb, Sidell, Neil, Yang, Danzhou

“…Abstract ER has emerged as one of the most effective targets for breast cancer therapy since the discovery of the estrogen receptor (ER) as the modulator of…”
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