Search Results - "Mathé, Ewy"

Network analyses in microbiome based on high-throughput multi-omics data by Liu, Zhaoqian, Ma, Anjun, Mathé, Ewy, Merling, Marlena, Ma, Qin, Liu, Bingqiang

“…Abstract Together with various hosts and environments, ubiquitous microbes interact closely with each other forming an intertwined system or community. Of…”
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Exploring NCATS in-house biomedical data for evidence-based drug repurposing by Liu, Fang, Patt, Andrew, Chen, Chloe, Huang, Ruili, Xu, Yanji, Mathé, Ewy A, Zhu, Qian

“…Drug repurposing is a strategy for identifying new uses of approved or investigational drugs that are outside the scope of the original medical indication…”
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Noninvasive Urinary Metabolomic Profiling Identifies Diagnostic and Prognostic Markers in Lung Cancer by MATHE, Ewy A, PATTERSON, Andrew D, KAZANDJIAN, Dickran G, HATZAKIS, Emmanuel, GONZALEZ, Frank J, HARRIS, Curtis C, HAZNADAR, Majda, MANNA, Soumen K, KRAUSZ, Kristopher W, BOWMAN, Elise D, SHIELDS, Peter G, IDLE, Jeffrey R, SMITH, Philip B, ANAMI, Katsuhiro

“…Lung cancer remains the most common cause of cancer deaths worldwide, yet there is currently a lack of diagnostic noninvasive biomarkers that could guide…”
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Integrative rare disease biomedical profile based network supporting drug repurposing or repositioning, a case study of glioblastoma by McGowan, Erin, Sanjak, Jaleal, Mathé, Ewy A, Zhu, Qian

“…Glioblastoma (GBM) is the most aggressive and common malignant primary brain tumor; however, treatment remains a significant challenge. This study aims to…”
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Recent advances in mass spectrometry-based computational metabolomics by Ebbels, Timothy M.D., van der Hooft, Justin J.J., Chatelaine, Haley, Broeckling, Corey, Zamboni, Nicola, Hassoun, Soha, Mathé, Ewy A.

“…The computational metabolomics field brings together computer scientists, bioinformaticians, chemists, clinicians, and biologists to maximize the impact of…”
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Urinary Metabolite Risk Biomarkers of Lung Cancer: A Prospective Cohort Study by Haznadar, Majda, Cai, Qiuyin, Krausz, Kristopher W, Bowman, Elise D, Margono, Ezra, Noro, Rintaro, Thompson, Matthew D, Mathé, Ewy A, Munro, Heather M, Steinwandel, Mark D, Gonzalez, Frank J, Blot, William J, Harris, Curtis C

“…Lung cancer is a major health burden causing 160,000 and 1.6 million deaths annually in the United States and worldwide, respectively. While seeking to…”
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NCATS Inxight Drugs: a comprehensive and curated portal for translational research by Siramshetty, Vishal B, Grishagin, Ivan, Nguyễn, Ðắc-Trung, Peryea, Tyler, Skovpen, Yulia, Stroganov, Oleg, Katzel, Daniel, Sheils, Timothy, Jadhav, Ajit, Mathé, Ewy A, Southall, Noel T

“…Abstract The United States has a complex regulatory scheme for marketing drugs. Understanding drug regulatory status is a daunting task that requires…”
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Self-organizing maps with variable neighborhoods facilitate learning of chromatin accessibility signal shapes associated with regulatory elements by Eicher, Tara, Chan, Jany, Luu, Han, Machiraju, Raghu, Mathé, Ewy A

“…Assigning chromatin states genome-wide (e.g. promoters, enhancers, etc.) is commonly performed to improve functional interpretation of these states. However,…”
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Metabolomics and Multi-Omics Integration: A Survey of Computational Methods and Resources by Eicher, Tara, Kinnebrew, Garrett, Patt, Andrew, Spencer, Kyle, Ying, Kevin, Ma, Qin, Machiraju, Raghu, Mathé, And Ewy A

“…As researchers are increasingly able to collect data on a large scale from multiple clinical and omics modalities, multi-omics integration is becoming a…”
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Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability by Williams, Jordan, Siramshetty, Vishal, Nguyễn, Ðắc-Trung, Padilha, Elias Carvalho, Kabir, Md, Yu, Kyeong-Ri, Wang, Amy Q., Zhao, Tongan, Itkin, Misha, Shinn, Paul, Mathé, Ewy A., Xu, Xin, Shah, Pranav

“…[Display omitted] Membrane permeability plays an important role in oral drug absorption. Caco-2 and Madin-Darby Canine Kidney (MDCK) cell culture systems have…”
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Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial by Song, Min-Ae, Reisinger, Sarah A, Freudenheim, Jo L, Brasky, Theodore M, Mathé, Ewy A, McElroy, Joseph P, Nickerson, Quentin A, Weng, Daniel Y, Wewers, Mark D, Shields, Peter G

“…Electronic cigarette (e-cig) use is continuing to increase, particularly among youth never-smokers, and is used by some smokers to quit. The acute and chronic…”
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Identification of transcription factor co-regulators that drive prostate cancer progression by Siddappa, Manjunath, Wani, Sajad A., Long, Mark D., Leach, Damien A., Mathé, Ewy A., Bevan, Charlotte L., Campbell, Moray J.

“…In prostate cancer (PCa), and many other hormone-dependent cancers, there is clear evidence for distorted transcriptional control as disease driver mechanisms…”
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Challenges in proteogenomics: a comparison of analysis methods with the case study of the DREAM proteogenomics sub-challenge by Eicher, Tara, Patt, Andrew, Kautto, Esko, Machiraju, Raghu, Mathé, Ewy, Zhang, Yan

“…Proteomic measurements, which closely reflect phenotypes, provide insights into gene expression regulations and mechanisms underlying altered phenotypes…”
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An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers by Robles, Ana I, Arai, Eri, Mathé, Ewy A, Okayama, Hirokazu, Schetter, Aaron J, Brown, Derek, Petersen, David, Bowman, Elise D, Noro, Rintaro, Welsh, Judith A, Edelman, Daniel C, Stevenson, Holly S, Wang, Yonghong, Tsuchiya, Naoto, Kohno, Takashi, Skaug, Vidar, Mollerup, Steen, Haugen, Aage, Meltzer, Paul S, Yokota, Jun, Kanai, Yae, Harris, Curtis C

“…Up to 30% stage I lung cancer patients suffer recurrence within 5 years of curative surgery. We sought to improve existing protein-coding gene and microRNA…”
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Modulation of anxiety-like behavior in galactooligosaccharide-fed mice: A potential role for bacterial tryptophan metabolites and reduced microglial reactivity by Spencer, Kyle D., Bline, Heather, Chen, Helen J., Verosky, Branden G., Hilt, Miranda E., Jaggers, Robert M., Gur, Tamar L., Mathé, Ewy A., Bailey, Michael T.

“…•Prebiotic galactooligosaccharide significantly reduced anxiety-like behavior as well as brain cytokine and chemokine gene expression.•Prebiotic…”
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IntLIM: integration using linear models of metabolomics and gene expression data by Siddiqui, Jalal K, Baskin, Elizabeth, Liu, Mingrui, Cantemir-Stone, Carmen Z, Zhang, Bofei, Bonneville, Russell, McElroy, Joseph P, Coombes, Kevin R, Mathé, Ewy A

“…Integration of transcriptomic and metabolomic data improves functional interpretation of disease-related metabolomic phenotypes, and facilitates discovery of…”
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Nucleotide, Phospholipid, and Kynurenine Metabolites Are Robustly Associated with COVID-19 Severity and Time of Plasma Sample Collection in a Prospective Cohort Study by Chatelaine, Haley A S, Chen, Yulu, Braisted, John, Chu, Su H, Chen, Qingwen, Stav, Meryl, Begum, Sofina, Diray-Arce, Joann, Sanjak, Jaleal, Huang, Mengna, Lasky-Su, Jessica, Mathé, Ewy A

“…Understanding the molecular underpinnings of disease severity and progression in human studies is necessary to develop metabolism-related preventative…”
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The International Conference on Intelligent Biology and Medicine (ICIBM) 2019: bioinformatics methods and applications for human diseases by Zhao, Zhongming, Dai, Yulin, Zhang, Chi, Mathé, Ewy, Wei, Lai, Wang, Kai

“…Between June 9-11, 2019, the International Conference on Intelligent Biology and Medicine (ICIBM 2019) was held in Columbus, Ohio, USA. The conference included…”
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A Workflow of Integrated Resources to Catalyze Network Pharmacology Driven COVID-19 Research by Zahoránszky-Kőhalmi, Gergely, Siramshetty, Vishal B., Kumar, Praveen, Gurumurthy, Manideep, Grillo, Busola, Mathew, Biju, Metaxatos, Dimitrios, Backus, Mark, Mierzwa, Tim, Simon, Reid, Grishagin, Ivan, Brovold, Laura, Mathé, Ewy A., Hall, Matthew D., Michael, Samuel G., Godfrey, Alexander G., Mestres, Jordi, Jensen, Lars J., Oprea, Tudor I.

“…In the event of an outbreak due to an emerging pathogen, time is of the essence to contain or to mitigate the spread of the disease. Drug repositioning is one…”
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Development and validation of PAMPA-BBB QSAR model to predict brain penetration potential of novel drug candidates by Kato, Rintaro, Zeng, Wenyu, Siramshetty, Vishal B, Williams, Jordan, Kabir, Md, Hagen, Natalie, Padilha, Elias C, Wang, Amy Q, Mathé, Ewy A, Xu, Xin, Shah, Pranav

“…Efficiently circumventing the blood-brain barrier (BBB) poses a major hurdle in the development of drugs that target the central nervous system. Although there…”
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