Synthesis of new quinazoline-containing hydroxamic acids as potential HDAC/VEGFR inhibitors. Unusual rearrangements with pyrrolidone ring opening and dehydration of 3-N-hydroxyquinazoline fragment containing tetracycles

[Display omitted] Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a “cap”. Further biological testing of the obtained compounds will give an opportunity to estimate the real pr...

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Bibliographic Details

Published in:	Tetrahedron letters Vol. 60; no. 51; p. 151315
Main Authors:	Kolotaev, Anton V., Matevosyan, Karine R., Osipov, Vasiliy N., Khachatryan, Derenik S.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 19-12-2019
Subjects:	HDAC/VEGFR2 Hybrid inhibitors Hydroxamic acids Quinazoline Targeted therapy HDAC/VEGFR2 Hydroxamic acids Quinazoline Targeted therapy Hybrid inhibitors
Online Access:	Get full text
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