Search Results - "Matesic, Lydia"

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway by Lee, Yu-Ru, Chen, Ming, Lee, Jonathan D, Zhang, Jinfang, Lin, Shu-Yu, Fu, Tian-Min, Chen, Hao, Ishikawa, Tomoki, Chiang, Shang-Yin, Katon, Jesse, Zhang, Yang, Shulga, Yulia V, Bester, Assaf C, Fung, Jacqueline, Monteleone, Emanuele, Wan, Lixin, Shen, Chen, Hsu, Chih-Hung, Papa, Antonella, Clohessy, John G, Teruya-Feldstein, Julie, Jain, Suresh, Wu, Hao, Matesic, Lydia, Chen, Ruey-Hwa, Wei, Wenyi, Pandolfi, Pier Paolo

“…Activation of tumor suppressors for the treatment of human cancer has been a long sought, yet elusive, strategy. PTEN is a critical tumor suppressive…”
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The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse by White, James P., Baynes, John W., Welle, Stephen L., Kostek, Matthew C., Matesic, Lydia E., Sato, Shuichi, Carson, James A.

“…Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The ApcMin/+ mouse is a…”
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The Nedd4-like family of E3 ubiquitin ligases and cancer by Chen, Ceshi, Matesic, Lydia E

“…Accumulating evidence suggests that E3 ubiquitin ligases play important roles in cancer development. In this article, we provide a comprehensive summary of the…”
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The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the Apc(Min/+) mouse by White, James P, Baynes, John W, Welle, Stephen L, Kostek, Matthew C, Matesic, Lydia E, Sato, Shuichi, Carson, James A

“…Muscle wasting that occurs with cancer cachexia is caused by an imbalance in the rates of muscle protein synthesis and degradation. The Apc(Min/+) mouse is a…”
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Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1 by Zhao, Lan, Huang, Jian, Zhang, Hengwei, Wang, Yi, Matesic, Lydia E., Takahata, Masahiko, Awad, Hani, Chen, Di, Xing, Lianping

“…Patients with chronic inflammatory disorders, such as rheumatoid arthritis, often have osteoporosis due to a combination of Tumor necrosis factor‐induced…”
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Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor by Chumanevich, Alexander A, Causey, Corey P, Knuckley, Bryan A, Jones, Justin E, Poudyal, Deepak, Chumanevich, Alena P, Davis, Tia, Matesic, Lydia E, Thompson, Paul R, Hofseth, Lorne J

“…Inflammatory bowel diseases (IBDs), mainly Crohn's disease and ulcerative colitis, are dynamic, chronic inflammatory conditions that are associated with an…”
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The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells by Rathinam, Chozhavendan, Matesic, Lydia E, Flavell, Richard A

“…The molecular machinery that regulates the self-renewal of hematopoietic stem cells remains elusive. Flavell and co-workers show that the type E3 ubiquitin…”
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The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20 by Harhaj, Nicole S, Parvatiyar, Kislay, Harhaj, Edward W, Copeland, Neal G, Shembade, Noula, Jenkins, Nancy A, Matesic, Lydia E

“…The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and cytokine-mediated activation of the transcription factor NF-κB; however,…”
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IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse by White, James P, Puppa, Melissa J, Sato, Shuichi, Gao, Song, Price, Robert L, Baynes, John W, Kostek, Matthew C, Matesic, Lydia E, Carson, James A

“…Muscle protein turnover regulation during cancer cachexia is being rapidly defined, and skeletal muscle mitochondria function appears coupled to processes…”
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WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models by Kishikawa, Takahiro, Higuchi, Hiroshi, Wang, Limei, Panch, Nivedita, Maymi, Valerie, Best, Sachem, Lee, Samuel, Notoya, Genso, Toker, Alex, Matesic, Lydia E, Wulf, Gerburg M, Wei, Wenyi, Otsuka, Motoyuki, Koike, Kazuhiko, Clohessy, John G, Lee, Yu-Ru, Pandolfi, Pier Paolo

“…Activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is a pervasive event in tumorigenesis due to PI3K mutation and dysfunction of…”
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ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways by Tao, MingFang, Scacheri, Peter C., Marinis, Jill M., Harhaj, Edward W., Matesic, Lydia E., Abbott, Derek W.

“…The inability to coordinate the signaling pathways that lead to proper cytokine responses characterizes the pathogenesis of inflammatory diseases such as…”
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Ubiquitin ligase Wwp1 gene deletion attenuates diastolic dysfunction in pressure-overload hypertrophy by Snyder, Laura B, Lai, Yimu, Doviak, Heather, Freeburg, Lisa A, Laney, Valerie K, Moore, Amber, Zellars, Kia N, Matesic, Lydia E, Spinale, Francis G

“…Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and accompanied by…”
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The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart by Matesic, Lydia E, Freeburg, Lisa A, Snyder, Laura B, Duncan, Lauren-Ashley, Moore, Amber, Perreault, Paige E, Zellars, Kia N, Goldsmith, Edie C, Spinale, Francis G

“…Ubiquitylation is a key event that regulates protein turnover, and induction of the ubiquitin ligase E3 WWP1 has been associated with age. Left ventricular…”
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Ubiquitin E3 Ligase Itch Negatively Regulates Osteoclast Formation by Promoting Deubiquitination of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 by Zhang, Hengwei, Wu, Chengwu, Matesic, Lydia E., Li, Xing, Wang, Zhiyu, Boyce, Brendan F., Xing, Lianping

“…Itch is a ubiquitin E3 ligase that regulates protein stability. Itch−/− mice develop an autoimmune disease phenotype characterized by itchy skin and multiorgan…”
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Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis by Basheer, Wassim A, Harris, Brett S, Mentrup, Heather L, Abreha, Measho, Thames, Elizabeth L, Lea, Jessica B, Swing, Deborah A, Copeland, Neal G, Jenkins, Nancy A, Price, Robert L, Matesic, Lydia E

“…Abstract Gap junctions (GJ) are intercellular channels composed of connexin subunits that play a critical role in a diverse number of cellular processes in all…”
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The ubiquitin ligase ITCH coordinates small intestinal epithelial homeostasis by modulating cell proliferation, differentiation, and migration by Mentrup, Heather L., Hartman, Amanda, Thames, Elizabeth L., Basheer, Wassim A., Matesic, Lydia E.

“…Maintenance of the intestinal mucosa is driven by local signals that coordinate epithelial proliferation, differentiation, and turnover in order to separate…”
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Identification of an organelle receptor for myosin-Va by Wu, Xufeng S, Rao, Kang, Zhang, Hong, Wang, Fei, Sellers, James R, Matesic, Lydia E, Copeland, Neal G, Jenkins, Nancy A, Hammer, John A

“…Little is known about how molecular motors bind to their vesicular cargo. Here we show that myosin-Va, an actin-based vesicle motor, binds to one of its…”
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Kinase-Independent Feedback of the TAK1/TAB1 Complex on BCL10 Turnover and NF-κB Activation by Moreno-García, Miguel E., Sommer, Karen, Rincon-Arano, Hector, Brault, Michelle, Ninomiya-Tsuji, Jun, Matesic, Lydia E., Rawlings, David J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mutations in Mlph, Encoding a Member of the Rab Effector Family, Cause the Melanosome Transport Defects Observed in leaden Mice by Matesic, Lydia E., Yip, Richard, Reuss, Andreé E., Swing, Deborah A., O'Sullivan, T. Norene, Fletcher, Colin F., Copeland, Neal G., Jenkins, Nancy A.

“…The d, ash, and In coat color mutations provide a unique model system for the study of vesicle transport in mammals. All three mutant loci encode genes that…”
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Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis by Kotakadi, Venkata S., Jin, Yu, Hofseth, Anne B., Ying, Lei, Cui, Xiangli, Volate, Suresh, Chumanevich, Alexander, Wood, Patricia A., Price, Robert L., McNeal, Anna, Singh, Udai P., Singh, Narendra P., Nagarkatti, Mitzi, Nagarkatti, Prakash S., Matesic, Lydia E., Auclair, Karine, Wargovich, Michael J., Hofseth, Lorne J.

“…Ulcerative colitis is a dynamic, chronic inflammatory condition of the colon associated with an increased colon cancer risk. Ginkgo biloba is a putative…”
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