Search Results - "Matern, Benedict M."

Snowflake: A deep learning-based human leukocyte antigen matching algorithm considering allele-specific surface accessibility by Niemann, Matthias, Matern, Benedict M., Spierings, Eric

“…Histocompatibility in solid-organ transplantation has a strong impact on long-term graft survival. Although recent advances in matching of both B-cell epitopes…”
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Peptides Derived From Mismatched Paternal Human Leukocyte Antigen Predicted to Be Presented by HLA-DRB1, -DRB3/4/5, -DQ, and -DP Induce Child-Specific Antibodies in Pregnant Women by Niemann, Matthias, Matern, Benedict M, Spierings, Eric, Schaub, Stefan, Hönger, Gideon

“…Predicted Indirectly ReCognizable Human Leukocyte Antigen (HLA) Epitopes (PIRCHE) are known to be a significant risk factor for the development of donor…”
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Paternal HLA‐Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial by Krog, Maria Christine, Peereboom, Emma T. M., Geneugelijk, Kirsten, Matern, Benedict M., Kolte, Astrid Marie, Christiansen, Ole Bjarne, Steffensen, Rudi, Nielsen, Henriette Svarre, Spierings, Eric

“…ABSTRACT Recurrent pregnancy loss (RPL), defined as two or more pregnancy losses before the 24th week of gestation, affects 1%–3% of women worldwide…”
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Quantifying uncertainty of molecular mismatch introduced by mislabeled ancestry using haplotype-based HLA genotype imputation by Matern, Benedict M, Spierings, Eric, Bandstra, Selle, Madbouly, Abeer, Schaub, Stefan, Weimer, Eric T, Niemann, Matthias

“…Modern histocompatibility algorithms depend on the comparison and analysis of high-resolution HLA protein sequences and structures, especially when considering…”
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Snowflake epitope matching correlates with child-specific antibodies during pregnancy and donor-specific antibodies after kidney transplantation by Niemann, Matthias, Strehler, Yara, Lachmann, Nils, Halleck, Fabian, Budde, Klemens, Hönger, Gideon, Schaub, Stefan, Matern, Benedict M., Spierings, Eric

“…Development of donor-specific human leukocyte antigen (HLA) antibodies (DSA) remains a major risk factor for graft loss following organ transplantation, where…”
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PIRCHE application major versions 3 and 4 lead to equivalent T cell epitope mismatch scores in solid organ and stem cell transplantation modules by Matern, Benedict M., Niemann, Matthias

“…PIRCHE scores in organ and stem cell transplantation have been shown to correlate with increased risk of donor-specific HLA antibodies and graft-versus-host…”
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Repeated local ellipsoid protrusion supplements HLA surface characterization by Niemann, Matthias, Matern, Benedict M., Spierings, Eric

“…Allorecognition of donor HLA is a major risk factor for long‐term kidney graft survival. Although several molecular matching algorithms have been proposed that…”
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The Value of Single-cell Technologies in Solid Organ Transplantation Studies by Peereboom, Emma T.M., Matern, Benedict M., Spierings, Eric, Geneugelijk, Kirsten

“…Single-cell technologies open up new opportunities to explore the behavior of cells at the individual level. For solid organ transplantation, single-cell…”
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PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation by Niemann, Matthias, Matern, Benedict M, Spierings, Eric

“…To optimize outcomes in solid organ transplantation, the HLA genes are regularly compared and matched between the donor and recipient. However, in many cases a…”
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Standard reference sequences for submission of HLA genotyping for the 18th International HLA and Immunogenetics Workshop by Matern, Benedict M., Mack, Steven J., Osoegawa, Kazutoyo, Maiers, Martin, Niemann, Matthias, Robinson, James, Heidt, Sebastiaan, Spierings, Eric

“…The International human leukocyte antigen (HLA) and Immunogenetics Workshops (IHIWs) have fostered international collaborations of researchers and experts in…”
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Using cloud infrastructure to facilitate data collection and conversion of HLA diagnostic data for the 18th International HLA and Immunogenetics Workshop by Matern, Benedict M., Niemann, Matthias, Nemparis, Ioannis, Schimanski, Andreas, Peereboom, Emma T. M., Kramer, Cynthia S. M., Heidt, Sebastiaan, Spierings, Eric

“…The International HLA and Immunogenetics Workshop (IHIW) is a recurring gathering of researchers, technologists and clinicians where participants contribute to…”
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Long-Read Nanopore Sequencing Validated for Human Leukocyte Antigen Class I Typing in Routine Diagnostics by Matern, Benedict M., Olieslagers, Timo I., Groeneweg, Mathijs, Duygu, Burcu, Wieten, Lotte, Tilanus, Marcel G.J., Voorter, Christina E.M.

“…Matching of human leukocyte antigen (HLA) gene polymorphisms by high-resolution DNA sequence analysis is the gold standard for determining compatibility…”
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Report from the extended HLA‐DPA1 ~ promoter ~ HLA‐DPB1 haplotype of the 18th international HLA and immunogenetics workshop by Truong, Linh, Matern, Benedict M., El‐Lagta, Naser, Mobegi, Fredrick M., Askar, Medhat, Ogret, Yeliz, Oguz, Fatma S., Kwok, Janette, D'Orsogna, Lloyd, Martinez, Patricia, Petersdorf, Effie, Tilanus, Marcel G. J., De Santis, Dianne

“…The primary goal of the HLA‐DPA1 ~ promoter ~ HLA‐DPB1 haplotype component of the 18th IHIWS was to characterise the extended haplotypes within the HLA‐DP…”
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Specific amino acid patterns define split specificities of HLA-B15 antigens enabling conversion from DNA-based typing to serological equivalents by Duygu, Burcu, Matern, Benedict M., Wieten, Lotte, Voorter, Christina E.M., Tilanus, Marcel G.J.

“…The HLA-B15 typing by serological approaches defined the serological subgroups (or splits) B62, B63, B75, B76, B77 and B70 (B71 and B72). The scarcity of sera…”
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Molecular matching tools for allocation and immunosuppression optimization. Ready for primetime? by Niemann, Matthias, Matern, Benedict M.

“…Purpose of review Molecular matching continues to be an important topic in organ transplantation. Over the years, several studies – larger and smaller –…”
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The Value of Single-cell Technologies in Solid Organ Transplantation Studies by Peereboom, Emma T.M., Matern, Benedict M., Spierings, Eric, Geneugelijk, Kirsten

“…Single-cell technologies open up new opportunities to explore the behavior of cells at the individual level. For solid organ transplantation, single-cell…”
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The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation by Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angélique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sébastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M., Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Garrigue, Valérie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladrière, Marc, Giral, Magali, Anglicheau, Dany, Süsal, Caner, Bahram, Seiamak

“…The identity of histocompatibility loci, besides human leukocyte antigen ( HLA ), remains elusive. The major histocompatibility complex (MHC) class I MICA gene…”
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OR25. The highly polymorphic HLA-DRA Gene: conserved and diverse regions within the HLA-DRA gene imply haplotypes of DRA[formula omitted]DRB3/4/5[formula omitted]DRB1[formula omitted]DQB1 by Matern, Benedict M., Olieslagers, Timo I., de Rooij, Laura, Voorter, Christien E., Groeneweg, Mathijs, Tilanus, Marcel G.

“…HLA-DRA is highly conserved compared to the other HLA genes. The gene is represented in IPD-IMGT/HLA by 7 alleles encoding two distinct proteins, and we…”
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T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation by Peereboom, Emma T M, Matern, Benedict M, Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, van Reekum, Franka E, Verhaar, Marianne C, Kamburova, Elena G, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Azam, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Fréderike J, de Vries, Aiko P J, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Otten, Henny G, Heidt, Sebastiaan, van Zuilen, Arjan D, Kobayashi, Takaaki, Geneugelijk, Kirsten, Spierings, Eric

“…CD4 T-helper cells play an important role in alloimmune reactions following transplantation by stimulating humoral as well as cellular responses, which might…”
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