Search Results - "Mateo de Acosta, Cristina"

Expression and biological characterization of an anti-CD20 biosimilar candidate antibody: A case study by Dorvignit, Denise, Palacios, Julio L., Merino, Maylin, Hernández, Tays, Sosa, Katya, Casacó, Angel, López-Requena, Alejandro, Mateo de Acosta, Cristina

“…The CD20 molecule is a non-glycosylated protein expressed mainly on the surface of B lymphocytes. In some pathogenic B cells, it shows an increased expression,…”
Get full text

Immunopotentiating properties of a multispecific α-anti-idiotype antibody by Tays Hernández, Cristina Mateo de Acosta, Rolando Pérez

“…Multispecificity is not a well-understood property of some antibodies. Different functions have been attributed to multispecific natural antibodies, commonly…”
Get full text

Anti-ganglioside antibody-induced tumor cell death by loss of membrane integrity by Roque-Navarro, Lourdes, Chakrabandhu, Krittalak, de León, Joel, Rodríguez, Sandra, Toledo, Carlos, Carr, Adriana, de Acosta, Cristina Mateo, Hueber, Anne-Odile, Pérez, Rolando

“…Gangliosides have been involved in multiple cellular processes such as growth, differentiation and adhesion, and more recently as regulators of cell death…”
Get full text

A cytotoxic humanized anti-ganglioside antibody produced in a murine cell line defective of N -glycolylated-glycoconjugates by Fernández-Marrero, Yuniel, Roque-Navarro, Lourdes, Hernández, Tays, Dorvignit, Denise, Molina-Pérez, Marively, González, Addys, Sosa, Katya, López-Requena, Alejandro, Pérez, Rolando, Mateo de Acosta, Cristina

“…Abstract Gangliosides containing the N -glycolyl (NGc) form of sialic acid are tumor-associated antigens and promising candidates for cancer therapy. We…”
Get full text

Switching on cytotoxicity by a single mutation at the heavy chain variable region of an anti-ganglioside antibody by Fernández-Marrero, Yuniel, Hernández, Tays, Roque-Navarro, Lourdes, Talavera, Ariel, Moreno, Ernesto, Griñán, Tania, Vázquez, Ana María, de Acosta, Cristina Mateo, Pérez, Rolando, López-Requena, Alejandro

“…Gangliosides are sialic acid-containing glycosphingolipids present in the plasma membrane of most mammalian cells. In humans, the expression of the…”
Get full text

Detection and Characterization of N-Glycolyated Gangliosides in Wilms Tumor by Immunohistochemistry by Scursoni, Alejandra M., Galluzzo, Laura, Camarero, Sandra, Pozzo, Norma, Gabri, Mariano R., de Acosta, Cristina Mateo, Vázquez, Ana María, Alonso, Daniel F., de Dávila, María Teresa G.

“…Gangliosides are glycolipids present on the cell surface. The N-glycolylated ganglioside NeuGc-GM3 has been described in some neoplasms, such as breast…”
Get full text

Non-classical binding of a polyreactive α-type anti-idiotypic antibody to B cells by Hernández, Tays, de Acosta, Cristina Mateo, López-Requena, Alejandro, Moreno, Ernesto, Alonso, Ruby, Fernández-Marrero, Yuniel, Pérez, Rolando

“…Detailed information on the immunological relevance of α-type anti-idiotypic antibodies is lacking after more than 30 years since Jerne postulated his…”
Get full text

Immunogenicity of autologous immunoglobulins: Principles and practices by López-Requena, Alejandro, Mateo De Acosta, Cristina, Vázquez, Ana María, Pérez, Rolando

“…The immunogenicity of immunoglobulin idiotypes in syngeneic systems is a rather rare phenomenon. Very few studies have attempted to determine the mechanisms…”
Get full text

Gangliosides, Ab1 and Ab2 antibodies III. The idiotype of anti-ganglioside mAb P3 is immunogenic in a T cell-dependent manner by López-Requena, Alejandro, Bestagno, Marco, Mateo de Acosta, Cristina, Cesco-Gaspere, Michela, Vázquez, Ana María, Pérez, Rolando, Burrone, Oscar R

“…P3 mAb is an IgM monoclonal antibody specific for N-glycolyl-containing gangliosides. The immunogenicity of the P3 idiotype has been previously described by…”
Get full text

Gangliosides, Ab1 and Ab2 antibodies IV. Dominance of VH domain in the induction of anti-idiotypic antibodies by gene gun immunization by López-Requena, Alejandro, Mateo de Acosta, Cristina, Bestagno, Marco, Vázquez, Ana María, Pérez, Rolando, Burrone, Oscar R

“…The heavy chain of anti-N-glycolyl-ganglioside P3 mAb plays the main role in its binding properties. At least one hybrid idiotype consisting on the P3 VH and…”
Get full text

B7 and 34B7 monoclonal antibodies: a theoretical approach to the molecular basis of immunoglobulin cross-reactive antibodies by Hernández, Tays, López-Requena, Alejandro, De Acosta, Cristina Mateo, Mustelier, Geraudis, Roque-Navarro, Lourdes, Pérez, Rolando

“…Neonatal natural antibodies (NAbs) are characterized by their high degree of idiotypic cross reactivity, together with some restrictions in the genetic…”
Get more information

Insights into the immunogenetic basis of two ganglioside-associated idiotypic networks by Rodríguez, Mabel, Roque-Navarro, Lourdes, López-Requena, Alejandro, Moreno, Ernesto, Mateo de Acosta, Cristina, Pérez, Rolando, María Vázquez, Ana

“…Abstract The heavy-chain variable regions (VH) from 14F7 MAb, an IgG1 antibody specific for GM3(NeuGc) ganglioside, and its anti-idiotype, the 4G9 MAb, were…”
Get full text

Construction of a recombinant non-mitogenic anti-human CD3 antibody by Hinojosa, Luis E, Hernández, Tays, de Acosta, Cristina Mateo, Montero, Enrique, Pérez, Rolando, López-Requena, Alejandro

“…IOR-T3, a mouse monoclonal antibody specific for human CD3, has been successfully used in the treatment of acute transplant rejection due to its potential as…”
Get more information

Production of an anti-TNFα antibody in murine myeloma cells by perfusion culture by Bueno-Soler, Alexi, Palacios-Oliva, Julio, Dorvignit-Pedroso, Denise, Quintana-Cantillo, Anelis, Ramirez-Roque, Yaima, Santo Tomas-Pompa, Julio, Solazabal-Armstrong, Joaquin Antonio, Ruiz-Ramirez, Ingrid, Mateo-de Acosta, Cristina, Boggiano-Ayo, Tammy, Lao-Gonzalez, Thailin

“…Infliximab is a mouse/human chimeric IgG1 monoclonal antibody which recognizes the proinflammatory cytokine, tumor necrosis factor α (TNFα), and inhibits…”
Get full text

Production of an anti-TNF[alpha] antibody in murine myeloma cells by perfusion culture by Bueno-Soler, Alexi, Palacios-Oliva, Julio, Dorvignit-Pedroso, Denise, Quintana-Cantillo, Anelis, Ramirez-Roque, Yaima, Santo Tomas-Pompa, Julio, Solazabal-Armstrong, Joaquin Antonio, Ruiz-Ramirez, Ingrid, Mateo-de Acosta, Cristina, Boggiano-Ayo, Tammy, Lao-Gonzalez, Thailin

“…Infliximab is a mouse/human chimeric IgG1 monoclonal antibody which recognizes the proinflammatory cytokine, tumor necrosis factor [alpha] (TNF[alpha]), and…”
Get full text

Gangliosides, Ab1 and Ab2 antibodies I. Towards a molecular dissection of an idiotype-anti-idiotype system by López-Requena, Alejandro, De Acosta, Cristina Mateo, Moreno, Ernesto, González, Majela, Puchades, Yaquelin, Talavera, Ariel, Vispo, Nelson Santiago, Vázquez, Ana María, Pérez, Rolando

“…This report is focused on the molecular basis for the interaction of a monoclonal antibody (mAb) and its anti-idiotypic mAb. P3 mAb (Ab1) recognizes…”
Get full text

Chimeric anti-N-glycolyl-ganglioside and its anti-idiotypic MAbs: immunodominance of their variable regions by López-Requena, Alejandro, Mateo de Acosta, Cristina, Pérez, Alexis, Valle, Aisel, Lombardero, Josefa, Sosa, Katya, Pérez, Rolando, Vázquez, Ana María

“…P3 monoclonal antibody (MAb) is a murine IgM that specifically recognizes N-glycolyl (NeuGc)-gangliosides and sulfatides. It also reacts with antigens…”
Get more information

Gangliosides, Ab1 and Ab2 antibodies II. Light versus heavy chain: An idiotype-anti-idiotype case study by López-Requena, Alejandro, Rodríguez, Mabel, de Acosta, Cristina Mateo, Moreno, Ernesto, Puchades, Yaquelin, González, Majela, Talavera, Ariel, Valle, Aisel, Hernández, Tays, Vázquez, Ana María, Pérez, Rolando

“…The antibody heavy chain is generally more important than the light chain for the interaction with the antigen, although many reports demonstrate the influence…”
Get full text

Gangliosides, Ab1 and Ab2 antibodiesIII. The idiotype of anti-ganglioside mAb P3 is immunogenic in a T cell-dependent manner by López-Requena, Alejandro, Bestagno, Marco, Mateo de Acosta, Cristina, Cesco-Gaspere, Michela, Vázquez, Ana María, Pérez, Rolando, Burrone, Oscar R.

Get full text

Gangliosides, Ab1 and Ab2 antibodiesIV. Dominance of VH domain in the induction of anti-idiotypic antibodies by gene gun immunization by López-Requena, Alejandro, Mateo de Acosta, Cristina, Bestagno, Marco, Vázquez, Ana María, Pérez, Rolando, Burrone, Oscar R.

Get full text