The effect of vitamin E on plasmatic malondialdehyde levels during surgical removal of ovarian and endometrial carcinomas

This study deals with the monitoring of plasmatic levels of malondialdehyde, as the main indicator of oxidative damage to biomembranes. Malondialdehyde is determined by high-performance liquid chromatography (HPLC) after derivatization employing 2,4-dinitrophenylhydrazine. A clinical study involving...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of gynaecological oncology Vol. 34; no. 4; p. 329
Main Authors:	Matejcková, J, Samec, M, Samcová, E, Rokyta, R, Tůma, P
Format:	Journal Article
Language:	English
Published:	Italy 2013
Subjects:	Adult Aged Antioxidants - pharmacology Chromatography, High Pressure Liquid Endometrial Neoplasms - blood Endometrial Neoplasms - surgery Female Humans Malondialdehyde - blood Middle Aged Ovarian Neoplasms - blood Ovarian Neoplasms - surgery Vitamin E - pharmacology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This study deals with the monitoring of plasmatic levels of malondialdehyde, as the main indicator of oxidative damage to biomembranes. Malondialdehyde is determined by high-performance liquid chromatography (HPLC) after derivatization employing 2,4-dinitrophenylhydrazine. A clinical study involving 20 female patients suffering from ovarian and endometrial carcinomas has demonstrated elevated levels of malondialdehyde (10.1 +/- 1.1 microM), compared with the control group (7.5 +/- 2.7 microM). It has been further verified that surgical removal of the tumor leads to an additional increase in the plasmatic malondialdehyde content. This unfavourable situation can be effectively eliminated by administration of a single dose of vitamin E prior to surgery.
ISSN:	0392-2936