Search Results - "Matchkov, Vladimir"

The vascular Na,K-ATPase: clinical implications in stroke, migraine, and hypertension by Staehr, Christian, Aalkjaer, Christian, Matchkov, Vladimir V

“…In the vascular wall, the Na,K-ATPase plays an important role in the control of arterial tone. Through cSrc signaling, it contributes to the modulation of Ca2+…”
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Hypertension and physical exercise: The role of oxidative stress by Korsager Larsen, Monica, Matchkov, Vladimir V.

“…Oxidative stress is associated with the pathogenesis of hypertension. Decreased bioavailability of nitric oxide (NO) is one of the mechanisms involved in the…”
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Demand creates its own supply: the Na/K-ATPase controls metabolic reserve and flexibility by Staehr, Christian, Matchkov, Vladimir V

“…The study by Kurtz et al. validated the hypothesis that the Na/K-ATPase controls metabolic capacity via Src kinase signalling. They found that regulatory…”
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Vascular smooth muscle cell phenotype is defined by Ca2+‐dependent transcription factors by Kudryavtseva, Olga, Aalkjær, Christian, Matchkov, Vladimir V

“…Ca²⁺ is an important second messenger in vascular smooth muscle cells (VSMCs). Therefore, VSMCs exercise tight control of the intracellular Ca²⁺ concentration…”
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Vascular microdomain signalling and possible novel treatments in cardiovascular diseases by Matchkov, Vladimir V.

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Specialized Functional Diversity and Interactions of the Na,K-ATPase by Matchkov, Vladimir V, Krivoi, Igor I

“…Na,K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal cells and vitally essential for their functions. A specialized functional…”
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Involvement of the Na+,K+‐ATPase isoforms in control of cerebral perfusion by Staehr, Christian, Rajanathan, Rajkumar, Matchkov, Vladimir V.

“…New Findings What is the topic of this review? In this review, we consider the role of the Na+,K+‐ATPase in cerebrovascular function and how it might be…”
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The Na,K-ATPase-Dependent Src Kinase Signaling Changes with Mesenteric Artery Diameter by Zhang, Lin, Aalkjaer, Christian, Matchkov, Vladimir V

“…Inhibition of the Na,K-ATPase by ouabain potentiates vascular tone and agonist-induced contraction. These effects of ouabain varies between different reports…”
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Microelectrodes for measurement of intracellular [K+] and [Na+]in the choroid plexus epithelium and cerebrospinal fluid by Berenji Ardestani, Simin, Matchkov, Vladimir V., Praetorius, Jeppe

“…The choroid plexus epithelium (CPE) has recently gained increasing interest as a potential target tissue to manipulating cerebrospinal fluid (CSF) production…”
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Endothelial dysfunction in small arteries and early signs  of atherosclerosis in ApoE knockout rats by Berenji Ardestani, Simin, Eftedal, Ingrid, Pedersen, Michael, Jeppesen, Per Bendix, Nørregaard, Rikke, Matchkov, Vladimir V.

“…Endothelial dysfunction is recognized as a major contributor to atherosclerosis and has been suggested to be evident far before plaque formation. Endothelial…”
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Does Src Kinase Mediated Vasoconstriction Impair Penumbral Reperfusion? by Guldbrandsen, Halvor Osterby, Staehr, Christian, Iversen, Nina Kerting, Postnov, Dmitry D., Matchkov, Vladimir V.

“…Despite successful recanalization, a significant number of patients with ischemic stroke experience impaired local brain tissue reperfusion with adverse…”
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Transglutaminase 2 Inhibitor LDN 27219 Age-Dependently Lowers Blood Pressure and Improves Endothelium-Dependent Vasodilation in Resistance Arteries by Pinilla, Estéfano, Comerma-Steffensen, Simon, Prat-Duran, Judit, Rivera, Luis, Matchkov, Vladimir V., Buus, Niels Henrik, Simonsen, Ulf

“…Transglutaminase 2 (TG2) is an enzyme which in the open conformation exerts transamidase activity, leading to protein cross-linking and fibrosis. In the closed…”
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Reply from Vladimir V. Matchkov and Christian Aalkjaer by Matchkov, Vladimir V., Aalkjaer, Christian

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Vascular smooth muscle BK channels limit ouabain‐induced vasocontraction: Dual role of the Na/K‐ATPase as a hub for Src‐kinase and the Na/Ca‐exchanger by Orth, Tobias, Pyanova, Anastasia, Lux, Simon, Kaiser, Peter, Reinheimer, Isabel, Nielsen, Daniel Løgstrup, Khalid, Josef Ali, Rognant, Salomé, Jepps, Thomas A., Matchkov, Vladimir V., Schubert, Rudolf

“…Large‐conductance, calcium‐activated potassium channels (BK channels) and the Na/K‐ATPase are expressed universally in vascular smooth muscle. The Na/K‐ATPase…”
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Intracellular Ca2+ Signalling and Phenotype of Vascular Smooth Muscle Cells by Matchkov, Vladimir V., Kudryavtseva, Olga, Aalkjaer, Christian

“…:  Vascular smooth muscle cells (VSMCs) express considerable plasticity in their phenotype and even can change their phenotype in vivo depending on the…”
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Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility by Homilius, Casper, Seefeldt, Jacob Marthinsen, Axelsen, Julie Sørensen, Pedersen, Tina Myhre, Sørensen, Trine Monberg, Nielsen, Roni, Wiggers, Henrik, Hansen, Jakob, Matchkov, Vladimir V., Bøtker, Hans Erik, Boedtkjer, Ebbe

“…The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressure in humans, but the cardiovascular…”
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Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome by Thorsen, Kasper, Dam, Vibeke S., Kjaer-Sorensen, Kasper, Pedersen, Lisbeth N., Skeberdis, V. Arvydas, Jurevičius, Jonas, Treinys, Rimantas, Petersen, Ida M. B. S., Nielsen, Morten S., Oxvig, Claus, Morth, J. Preben, Matchkov, Vladimir V., Aalkjær, Christian, Bundgaard, Henning, Jensen, Henrik K.

“…Patients with short QT syndrome (SQTS) may present with syncope, ventricular fibrillation or sudden cardiac death. Six SQTS susceptibility genes, encoding…”
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Stress adaptation in rats associate with reduced expression of cerebrovascular K v 7.4 channels and biphasic neurovascular responses by Staehr, Christian, Bouzinova, Elena V, Wiborg, Ove, Matchkov, Vladimir V

“…Neurovascular coupling ensures rapid and precise delivery of O and nutrients to active brain regions. Chronic stress is known to disturb neurovascular…”
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Abnormal neurovascular coupling as a cause of excess cerebral vasodilation in familial migraine by Staehr, Christian, Rajanathan, Rajkumar, Postnov, Dmitry D, Hangaard, Lise, Bouzinova, Elena V, Lykke-Hartmann, Karin, Bach, Flemming W, Sandow, Shaun L, Aalkjaer, Christian, Matchkov, Vladimir V

“…Abstract Aims Acute migraine attack in familial hemiplegic migraine type 2 (FHM2) patients is characterized by sequential hypo- and hyperperfusion. FHM2 is…”
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Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression by Matchkov, Vladimir V, Kravtsova, Violetta V, Wiborg, Ove, Aalkjaer, Christian, Bouzinova, Elena V

“…Major depression is known to be associated with cardiovascular abnormalities, and oxidative stress has been suggested to play a role. We tested the hypothesis…”
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