Search Results - "Matchett, Kylie P."

An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis by Wang, Shuang, Li, Kenneth, Pickholz, Eliana, Dobie, Ross, Matchett, Kylie P, Henderson, Neil C, Carrico, Chris, Driver, Ian, Borch Jensen, Martin, Chen, Li, Petitjean, Mathieu, Bhattacharya, Dipankar, Fiel, Maria I, Liu, Xiao, Kisseleva, Tatiana, Alon, Uri, Adler, Miri, Medzhitov, Ruslan, Friedman, Scott L

“…Advanced hepatic fibrosis, driven by the activation of hepatic stellate cells (HSCs), affects millions worldwide and is the strongest predictor of mortality in…”
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Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis by Dobie, Ross, Wilson-Kanamori, John R., Henderson, Beth E.P., Smith, James R., Matchett, Kylie P., Portman, Jordan R., Wallenborg, Karolina, Picelli, Simone, Zagorska, Anna, Pendem, Swetha V., Hudson, Thomas E., Wu, Minnie M., Budas, Grant R., Breckenridge, David G., Harrison, Ewen M., Mole, Damian J., Wigmore, Stephen J., Ramachandran, Prakash, Ponting, Chris P., Teichmann, Sarah A., Marioni, John C., Henderson, Neil C.

“…Iterative liver injury results in progressive fibrosis disrupting hepatic architecture, regeneration potential, and liver function. Hepatic stellate cells…”
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Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth by Lechertier, Tanguy, Reynolds, Louise E., Kim, Hyojin, Pedrosa, Ana Rita, Gómez-Escudero, Jesús, Muñoz-Félix, José M., Batista, Silvia, Dukinfield, Matthew, Demircioglu, Fevzi, Wong, Ping Pui, Matchett, Kylie P., Henderson, Neil C., D’Amico, Gabriela, Parsons, Maddy, Harwood, Catherine, Meier, Pascal, Hodivala-Dilke, Kairbaan M.

“…The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour…”
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Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth by Lechertier, Tanguy, Reynolds, Louise E., Kim, Hyojin, Pedrosa, Ana Rita, Gómez-Escudero, Jesús, Muñoz-Félix, José M., Batista, Silvia, Dukinfield, Matthew, Demircioglu, Fevzi, Wong, Ping Pui, Matchett, Kylie P., Henderson, Neil C., D’Amico, Gabriela, Parsons, Maddy, Harwood, Catherine, Meier, Pascal, Hodivala-Dilke, Kairbaan M.

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Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis by Ramachandran, Prakash, Matchett, Kylie P., Dobie, Ross, Wilson-Kanamori, John R., Henderson, Neil C.

“…Liver disease is a major global health-care problem, affecting an estimated 844 million people worldwide. Despite this substantial burden, therapeutic options…”
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Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells by Matthews, Olivia, Morrison, Emma E., Tranter, John D., Starkey Lewis, Philip, Toor, Iqbal S., Srivastava, Abhishek, Sargeant, Rebecca, Rollison, Helen, Matchett, Kylie P., Kendall, Timothy J., Gray, Gillian A., Goldring, Chris, Park, Kevin, Denby, Laura, Dhaun, Neeraj, Bailey, Matthew A., Henderson, Neil C., Williams, Dominic, Dear, James W.

“…Extracellular microRNAs enter kidney cells and modify gene expression. We used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to…”
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Spatial genomics: mapping human steatotic liver disease by Matchett, Kylie P., Paris, Jasmin, Teichmann, Sarah A., Henderson, Neil C.

“…Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alcoholic fatty liver disease) is a leading cause of chronic liver…”
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Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells by Wong, Ping-Pui, Muñoz-Félix, José M., Hijazi, Maruan, Kim, Hyojin, Robinson, Stephen D., De Luxán-Delgado, Beatriz, Rodríguez-Hernández, Irene, Maiques, Oscar, Meng, Ya-Ming, Meng, Qiong, Bodrug, Natalia, Dukinfield, Matthew Scott, Reynolds, Louise E., Elia, George, Clear, Andrew, Harwood, Catherine, Wang, Yu, Campbell, James J., Singh, Rajinder, Zhang, Penglie, Schall, Thomas J., Matchett, Kylie P., Henderson, Neil C., Szlosarek, Peter W., Dreger, Sally A., Smith, Sally, Jones, J. Louise, Gribben, John G., Cutillas, Pedro R., Meier, Pascal, Sanz-Moreno, Victoria, Hodivala-Dilke, Kairbaan M.

“…Enhanced blood vessel (BV) formation is thought to drive tumor growth through elevated nutrient delivery. However, this observation has overlooked potential…”
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Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis by O'Sullivan, Eoin D, Mylonas, Katie J, Xin, Cuiyan, Baird, David P, Carvalho, Cyril, Docherty, Marie-Helena, Campbell, Ross, Matchett, Kylie P, Waddell, Scott H, Walker, Alexander D, Gallagher, Kevin M, Jia, Siyang, Leung, Steve, Laird, Alexander, Wilflingseder, Julia, Willi, Michaela, Reck, Maximilian, Finnie, Sarah, Pisco, Angela, Gordon-Keylock, Sabrina, Medvinsky, Alexander, Boulter, Luke, Henderson, Neil C, Kirschner, Kristina, Chandra, Tamir, Conway, Bryan R, Hughes, Jeremy, Denby, Laura, Bonventre, Joseph V, Ferenbach, David A

“…Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs, including the kidney and heart. Glioma-associated oncogene 1…”
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Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration by Greenhalgh, Stephen N., Matchett, Kylie P., Taylor, Richard S., Huang, Katherine, Li, John T., Saeteurn, Koy, Donnelly, Mhairi C., Simpson, Eilidh E.M., Pollack, Joshua L., Atakilit, Amha, Simpson, Kenneth J., Maher, Jacquelyn J., Iredale, John P., Sheppard, Dean, Henderson, Neil C.

“…Recent fate-mapping studies in mice have provided substantial evidence that mature adult hepatocytes are a major source of new hepatocytes after liver injury…”
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