Search Results - "Matarazzo, Christopher"
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Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells
Published in Frontiers in oncology (14-01-2020)“…Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by…”
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Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies
Published in Physiological genomics (01-09-2023)“…High-altitude (>2,500 m) residence increases the risk of pregnancy vascular disorders such as fetal growth restriction and preeclampsia, each characterized by…”
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Genomic Selection Signals in Andean Highlanders Reveal Adaptive Placental Metabolic Phenotypes That Are Disrupted in Preeclampsia
Published in Hypertension (Dallas, Tex. 1979) (01-02-2024)“…The chronic hypoxia of high-altitude residence poses challenges for tissue oxygen supply and metabolism. Exposure to high altitude during pregnancy increases…”
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AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies
Published in American journal of physiology. Heart and circulatory physiology (01-07-2020)“…High-altitude (>2,500 m) residence increases the incidence of intrauterine growth restriction (IUGR) due, in part, to reduced uterine artery blood flow and…”
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High altitude regulates the expression of AMPK pathways in human placenta
Published in Placenta (Eastbourne) (15-01-2021)“…High-altitude (>2500 m) residence augments the risk of intrauterine growth restriction (IUGR) and preeclampsia likely due, in part, to uteroplacental…”
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