Search Results - "Matalka, Khalid Z."

IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors by Alshaker, Heba A, Matalka, Khalid Z

“…Multiple innate and adaptive immune effector cells and molecules partake in the recognition and destruction of cancer cells to protect against growing tumors,…”
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Structure–activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies by Jawabrah Al-Hourani, Baker, Al-Awaida, Wajdy, Matalka, Khalid Z., El-Barghouthi, Musa I., Alsoubani, Fatima, Wuest, Frank

“…[Display omitted] •New series of 1,5-disubstituted tetrazoles were designed and synthesized.•In vitro bioassay data of the novel azoles as COX-1/COX-2…”
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Eriobotrya japonica Water Extract Characterization: An Inducer of Interferon-Gamma Production Mainly by the JAK-STAT Pathway by Matalka, Khalid Z, Abdulridha, Nada A, Badr, Mujtaba M, Mansoor, Kenza, Qinna, Nidal A, Qadan, Fadi

“…Eriobotrya japonica (Thunb.) Lindl. (Loquat) (EJ) has been used as a medicinal plant to treat chronic bronchitis, coughs, phlegm, high fever and gastro-enteric…”
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A Functional Food Mixture "Protector" Reinforces the Protective Immune Parameters against Viral Flu Infection in Mice by Mansoor, Kenza A, Qadan, Fadi, Schmidt, Mathias, Qinna, Nidal A, Badr, Mujtaba, Matalka, Khalid Z

“…: Viral influenza infection causes serious health issues especially when an outbreak occurs. Although influenza virus vaccines are available and each year…”
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Pleiotropic Anticancer Properties of Scorpion Venom Peptides: Rhopalurus princeps Venom as an Anticancer Agent by Mikaelian, Arthur G, Traboulay, Eric, Zhang, Xiaofei Michael, Yeritsyan, Emma, Pedersen, Peter L, Ko, Young Hee, Matalka, Khalid Z

“…To date, the success of conventional chemotherapy, radiotherapy, and targeted biological therapies in cancer treatment is not satisfactory. The main reasons…”
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Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo by Qa’dan, Fadi, Verspohl, Eugen. J., Nahrstedt, Adolf, Petereit, Frank, Matalka, Khalid Z.

“…Eriobotrya japonica leaves had been used traditionally for the treatment of diabetes mellitus by immersing the dried leaves in a hot water drink. Few studies…”
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Glucosamine modulates propranolol pharmacokinetics via intestinal permeability in rats by Al Shaker, Hanadi A., Qinna, Nidal A., Badr, Mujtaba, Al Omari, Mahmoud M.H., Idkaidek, Nasir, Matalka, Khalid Z., Badwan, Adnan A.

“…Propranolol (PROP) undergoes extensive first-pass metabolism by the liver resulting in a relatively low bioavailability (13–23%); thus, multiple oral doses are…”
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Age of Natural Menopause Among Jordanian Women and Factors Related to Premature and Early Menopause by Bustami, Mona, Matalka, Khalid Z, Elyyan, Yousef, Hussein, Nagham, Hussein, Nour, Abu Safieh, Nayef, Thekrallah, Fida, Mallah, Eyad, Abu-Qatouseh, Luay, Arafat, Tawfiq

“…The aim of this study was to assess factors related to the onset of premature/early natural menopause among Jordanian women. A cross-sectional study was…”
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Glucosamine enhances paracetamol bioavailability by reducing its metabolism by Qinna, Nidal A, Shubbar, Maryam H, Matalka, Khalid Z, Al-Jbour, Nawzat, Ghattas, Mohammad A, Badwan, Adnan A

“…Paracetamol has an extensive first-pass metabolism that highly affects its bioavailability (BA); thus, dose may be repeated several times a day in order to…”
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The Prevalence of Overweight and Obesity Among Women in Jordan: A Risk Factor for Developing Chronic Diseases by Bustami, Mona, Matalka, Khalid Z, Mallah, Eyad, Abu-Qatouseh, Luay, Abu Dayyih, Wael, Hussein, Nour, Abu Safieh, Nayef, Elyyan, Yousef, Hussein, Nagham, Arafat, Tawfiq

“…The study aimed to investigate the prevalence of obesity among Jordanian women and its association with a wide range of chronic diseases. Subjects were…”
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Pomegranate and licorice juices modulate metformin pharmacokinetics in rats by Awad, Riad, Mallah, Eyad, Khawaja, Bayan Al, Dayyih, Wael Abu, El-Hajji, Feras, Matalka, Khalid Z, Arafat, Tawfiq

“…Food or drinks may significantly alter the pharmacokinetics and pharmacodynamics of drugs which may lead to adverse events. A drug such as metformin is widely…”
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The effect of estradiol, but not progesterone, on the production of cytokines in stimulated whole blood, is concentration-dependent by Matalka, Khalid Z

“…The purpose of this study was to determine the effects of estradiol and progesterone on interferon-gamma (IFN-gamma), interleukin (IL)-12, IL-10 and tumor…”
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A Bioactive Prodelphinidin from Mangifera indica Leaf Extract by Tawaha, Khaled, Sadi, Rasha, Qa’dan, Fadi, Matalka, Khalid Z., Nahrstedt, Adolf

“…A new trimeric proanthocyanidin, epigallocatechin-3-O-gallat-(4β→8)-epigallocatechin- (4β→8)-catechin (1), was isolated together with three known flavan-3-ols,…”
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Eriobotrya japonica hydrophilic extract modulates cytokines in normal tissues, in the tumor of Meth-A-fibrosarcoma bearing mice, and enhances their survival time by Alshaker, Heba A, Qinna, Nidal A, Qadan, Fadi, Bustami, Mona, Matalka, Khalid Z

“…Cytokines play a key role in the immune response to developing tumors, and therefore modulating their levels and actions provides innovative strategies for…”
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Anti-inflammatory aminoacetylenic isoindoline-1,3-dione derivatives modulate cytokines production from different spleen cell populations by Matalka, Khalid Z., Alfarhoud, Fatema, Qinna, Nidal A., Mallah, Eyad M., Abu-Dayyih, Wael A., Muhi-eldeen, Zuhair A.

“…We recently designed a series of N-[4-(t-amino-yl)-but-2-yn-1-yl] isoindoline-1,3-diones as anti-inflammatory compounds, called ZM compounds. These ZM…”
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Synthesis and pharmacological evaluation of aminoacetylenic isoindoline-1,3-dione derivatives as anti-inflammatory agents by Al-Qaisi, Jinan A., Alhussainy, Tawfik M., Qinna, Nidal A., Matalka, Khalid Z., Al-Kaissi, Elham N., Muhi-Eldeen, Zuhair A.

“…Aminoacetylenic isoindoline-1,3-dione derivatives were synthesized from the reaction of potassium phthalimide with propargyl bromide to generate…”
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Dopamine selectively modulates lipopolysaccharide-induced TNF-alpha, IFN-gamma and IL-10 within mice tissues by Matalka, Khalid Z, Attallah, Lama J, Qinna, Nidal A, Alhussainy, Tawfiq

“…Dopamine (DA) administration in sepsis is used to modulate the hypotensive condition and to normalize the blood vessels perfusion. However, whether this…”
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Plasma concentrations of 25-hydroxyvitamin D among Jordanians: Effect of biological and habitual factors on vitamin D status by Mallah, Eyad M, Hamad, Mohammad F, Elmanaseer, Mays A, Qinna, Nidal A, Idkaidek, Nasir M, Arafat, Tawfiq A, Matalka, Khalid Z

“…Vitamin D is cutaneously synthesized following sun exposure (vitamin D3) as well as it is derived from dietary intake (vitamin D3 and D2). Vitamin D2 and D3…”
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Dichloroacetate modulates cytokines toward T helper 1 function via induction of the interleukin-12-interferon-γ pathway by Badr, Mujtaba M, Qinna, Nidal A, Qadan, Fadi, Matalka, Khalid Z

“…Dichloroacetate (DCA) is one of the new, promising anticancer drugs. DCA restores normal mitochondrial function and enables cancer cells to undergo apoptosis…”
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Prolactin enhances production of interferon-γ, interleukin-12, and interleukin-10, but not of tumor necrosis factor-α, in a stimulus-specific manner by Matalka, Khalid Z.

“…Prolactin, an anterior pituitary hormone, has been shown to have a role in immunomodulation. Some reports have shown the importance of prolactin in activating…”
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