Search Results - "Matławska, Ksenia"

Epigenetic silencing of SOCS5 potentiates JAK‐STAT signaling and progression of T‐cell acute lymphoblastic leukemia by Sharma, Nitesh D., Nickl, Christian K., Kang, Huining, Ornatowski, Wojciech, Brown, Roger, Ness, Scott A., Loh, Mignon L., Mullighan, Charles G., Winter, Stuart S., Hunger, Stephen P., Cannon, Judy L., Matlawska‐Wasowska, Ksenia

“…Activating mutations in cytokine receptors and transcriptional regulators govern aberrant signal transduction in T‐cell lineage acute lymphoblastic leukemia…”
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Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells by Sullivan-Reed, Katherine, Bolton-Gillespie, Elisabeth, Dasgupta, Yashodhara, Langer, Samantha, Siciliano, Micheal, Nieborowska-Skorska, Margaret, Hanamshet, Kritika, Belyaeva, Elizaveta A., Bernhardy, Andrea J., Lee, Jaewong, Moore, Morgan, Zhao, Huaqing, Valent, Peter, Matlawska-Wasowska, Ksenia, Müschen, Markus, Bhatia, Smita, Bhatia, Ravi, Johnson, Neil, Wasik, Mariusz A., Mazin, Alexander V., Skorski, Tomasz

“…PARP inhibitors (PARPis) have been used to induce synthetic lethality in BRCA-deficient tumors in clinical trials with limited success. We hypothesized that…”
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The Expression Pattern of Adhesion G Protein-Coupled Receptor F5 Is Related to Cell Adhesion and Metastatic Pathways in Colorectal Cancer-Comprehensive Study Based on In Silico Analysis by Kang, Huining, Fichna, Jakub, Matlawska-Wasowska, Ksenia, Jacenik, Damian

“…Adhesion G protein-coupled receptor F5 (ADGRF5) is involved inthe neoplastic transformation of some cancer types. However, the significance of expression…”
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Evaluation of cytotoxicity of new trans-palladium(II) complex in human cells in vitro by Kontek, Renata, Matławska-Wasowska, Ksenia, Kalinowska-Lis, Urszula, Kontek, Bogdan, Ochocki, Justyn

“…Studies of cytotoxicity allow to elucidate the mechanisms by which chemical compounds influence cells and tissues. On the basis of the structural analogy…”
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Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy by Ksionda, Olga, Mues, Marsilius, Wandler, Anica M, Donker, Lisa, Tenhagen, Milou, Jun, Jesse, Ducker, Gregory S, Matlawska-Wasowska, Ksenia, Shannon, Kevin, Shokat, Kevan M, Roose, Jeroen P

“…T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer. Poly-chemotherapy with cytotoxic and genotoxic drugs causes substantial…”
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Metabolic Reprogramming and Cell Adhesion in Acute Leukemia Adaptation to the CNS Niche by Sharma, Nitesh D, Keewan, Esra'a, Matlawska-Wasowska, Ksenia

“…Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are…”
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Epigenetic silencing of SOCS 5 potentiates JAK ‐ STAT signaling and progression of T‐cell acute lymphoblastic leukemia by Sharma, Nitesh D., Nickl, Christian K., Kang, Huining, Ornatowski, Wojciech, Brown, Roger, Ness, Scott A., Loh, Mignon L., Mullighan, Charles G., Winter, Stuart S., Hunger, Stephen P., Cannon, Judy L., Matlawska‐Wasowska, Ksenia

“…Activating mutations in cytokine receptors and transcriptional regulators govern aberrant signal transduction in T‐cell lineage acute lymphoblastic leukemia…”
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Dysregulated transcriptional networks in KMT2A- and MLLT10 -rearranged T-ALL by Kang, Huining, Sharma, Nitesh D, Nickl, Christian K, Devidas, Meenakshi, Loh, Mignon L, Hunger, Stephen P, Dunsmore, Kimberly P, Winter, Stuart S, Matlawska-Wasowska, Ksenia

“…For children and young adults with T-lineage acute lymphoblastic leukemia (T-ALL), event free survival following relapse is < 10%. We recently showed that…”
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Integration of ruxolitinib into dose‐intensified therapy targeted against a novel JAK2 F694L mutation in B‐precursor acute lymphoblastic leukemia by Mayfield, Jodi R., Czuchlewski, David R., Gale, James M., Matlawska‐Wasowska, Ksenia, Vasef, Mohammad A., Nickl, Christian, Pickett, Gavin, Ness, Scott A., Winter, Stuart S.

“…A 17‐year‐old girl with B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) with persistent minimal residual disease (MRD) who underwent standard…”
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Characterization of the anti‐CD22 targeted therapy, moxetumomab pasudotox, for B‐cell precursor acute lymphoblastic leukemia by Kinjyo, Ichiko, Matlawska‐Wasowska, Ksenia, Chen, Xiaoru, Monks, Noel R., Burke, Patricia, Winter, Stuart S., Wilson, Bridget S.

“…Moxetumomab pasudotox is a second‐generation recombinant immunotoxin against CD22 on B‐cell lineages. Antileukemic activity has been demonstrated in children…”
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The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis by Matlawska-Wasowska, Ksenia, Finn, Rebecca, Mustel, Ana, O'Byrne, Conor P, Baird, Alan W, Coffey, Eleanor T, Boyd, Aoife

“…Vibrio parahaemolyticus is a food-borne pathogen causing inflammation of the gastrointestinal epithelium. Pathogenic strains of this bacterium possess two Type…”
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Synthesis, spectroscopy and antiproliferative activity of cis- and trans-platinum(II) complexes with diethyl (pyridin-4-ylmethyl)phosphate. X-ray crystal structure of trans-Pt(II) complex by Kalinowska, Urszula, Matławska, Ksenia, Chęcińska, Lilianna, Domagała, Małgorzata, Kontek, Renata, Osiecka, Regina, Ochocki, Justyn

“…Preparations of cis- and trans-platinum(II) complexes of diethyl (pyridin-4-ylmethyl)phosphate (4-pmOpe) have been described. These complexes were identified…”
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Abstract 4129: RUNX2 as a regulator of high-risk T-ALL by Sharma, Nitesh Devinarayan, Nickl, Christian K., Winter, Stuart S., Kang, Huining, Wasowska, Ksenia Matlawska

“…For patients with T-cell lineage acute lymphoblastic leukemia (T-ALL) who fail induction or relapse, event free survival is <10%. Mixed lineage leukemia gene…”
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Characterization of the Anti-CD22 targeted therapy, moxetumomab pasudotox, for BCP-ALL (TUM3P.1053) by Kinjo, Ichiko, Matlawska, Ksenia, Winter, Stuart, Burke, Patricia, Wilson, Bridget

“…Moxetumomab pasudotox (moxe, HA22, CAT-8015) is a recombinant, affinity optimized anti-CD22 immunotoxin. The demonstrated antitumor activity of moxe in…”
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The Emerging Role of Suppressors of Cytokine Signaling (SOCS) in the Development and Progression of Leukemia by Keewan, Esra'a, Matlawska-Wasowska, Ksenia

“…Cytokines are pleiotropic signaling molecules that execute an essential role in cell-to-cell communication through binding to cell surface receptors. Receptor…”
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Trans geometry in platinum antitumor complexes by Kalinowska-Lis, Urszula, Ochocki, Justyn, Matlawska-Wasowska, Ksenia

“…In this paper we summarize the work on the development of trans-platinum complexes as antitumor agents during the last 15 years. We review the structures and…”
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Drugging DNA repair to target T-ALL cells by Dasgupta, Yashodhara, Golovine, Konstantin, Nieborowska-Skorska, Margaret, Luo, Li, Matlawska-Wasowska, Ksenia, Mullighan, Charles G., Skorski, Tomasz

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The antioxidants, vitamin A and E but not vitamin C and melatonin enhance the proapoptotic effects of irinotecan in cancer cells in vitro by Kontek, Renata, Jakubczak, Marta, Matlawska-Wasowska, Ksenia

“…•Vitamin A and E enhance the proapoptotic activity of irinotecan in human cancer cells.•Vitamin A and E did not stimulate a high-level of necrosis in…”
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Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity by Perez, Dominique R., Sklar, Larry A., Chigaev, Alexandre, Matlawska-Wasowska, Ksenia

“…While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell…”
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CXCR3/CXCL10 Signaling Pathway Drives T-ALL into the CNS/Meningeal Microenvironment by Sharma, Nitesh D., Keewan, Esra'a, Ornatowski, Wojciech, Nysus, Monique, Paul, Silpita, Jacquez, Quiteria, Myers, Bianca L., Kang, Huining, Zychowski, Katherine E., Winter, Stuart S, Hunger, Stephen P., Loh, Mignon L., Castillo, Eliseo, Vue, Tou, Jones, Nicholas, Ntziachristos, Panagiotis, Matlawska-Wasowska, Ksenia

“…Cure rates for T-cell acute lymphoblastic leukemia (T-ALL) have improved significantly, but central nervous system (CNS) involvement leads to a poor prognosis…”
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