Search Results - "Masvekar, Ruturaj"

Cerebrospinal Fluid Biomarkers of Myeloid and Glial Cell Activation Are Correlated With Multiple Sclerosis Lesional Inflammatory Activity by Masvekar, Ruturaj, Phillips, Jonathan, Komori, Mika, Wu, Tianxia, Bielekova, Bibiana

“…Multiple sclerosis (MS)-related inflammation can be divided into lesional activity, mediated by immune cells migrating from the periphery to the central…”
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HIV-1 and morphine regulation of autophagy in microglia: limited interactions in the context of HIV-1 infection and opioid abuse by El-Hage, Nazira, Rodriguez, Myosotys, Dever, Seth M, Masvekar, Ruturaj R, Gewirtz, David A, Shacka, John J

“…Microglia are the predominant resident central nervous system (CNS) cell type productively infected by HIV-1, and play a key role in the progression of…”
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Morphine enhances HIV-1SF162-mediated neuron death and delays recovery of injured neurites by Masvekar, Ruturaj R, El-Hage, Nazira, Hauser, Kurt F, Knapp, Pamela E

“…HIV-1 enters the CNS soon after initial systemic infection; within the CNS parenchyma infected and/or activated perivascular macrophages, microglia and…”
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Productive infection of human neural progenitor cells by R5 tropic HIV-1: opiate co-exposure heightens infectivity and functional vulnerability by Balinang, Joyce M, Masvekar, Ruturaj R, Hauser, Kurt F, Knapp, Pamela E

“…OBJECTIVE:Human immunodeficiency virus type-1 (HIV-1) causes a spectrum of CNS complications; many are worsened by opiate co-exposure. Human neural progenitor…”
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Neurofilament light chain levels correlate with clinical measures in CLN3 disease by Dang Do, An N., Sinaii, Ninet, Masvekar, Ruturaj R., Baker, Eva H., Thurm, Audrey E., Soldatos, Ariane G., Bianconi, Simona E., Bielekova, Bibiana, Porter, Forbes D.

“…CLN3 disease is a neurodegenerative disorder with onset in childhood. It affects multiple functions at different developmental stages. Incomplete understanding…”
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Prognostic value of serum/plasma neurofilament light chain for COVID‐19‐associated mortality by Masvekar, Ruturaj R., Kosa, Peter, Jin, Kimberly, Dobbs, Kerry, Stack, Michael A., Castagnoli, Riccardo, Quaresima, Virginia, Su, Helen C., Imberti, Luisa, Notarangelo, Luigi D., Bielekova, Bibiana

“…Objective Given the continued spread of coronavirus 2, the early predictors of coronavirus disease 19 (COVID‐19) associated mortality might improve patients'…”
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Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis by Abdelhak, Ahmed, Barba, Lorenzo, Romoli, Michele, Benkert, Pascal, Conversi, Francesco, D’Anna, Lucio, Masvekar, Ruturaj R., Bielekova, Bibiana, Prudencio, Mercedes, Petrucelli, Leonard, Meschia, James F., Erben, Young, Furlan, Roberto, De Lorenzo, Rebecca, Mandelli, Alessandra, Sutter, Raoul, Hert, Lisa, Epple, Varenka, Marastoni, Damiano, Sellner, Johann, Steinacker, Petra, Aamodt, Anne Hege, Heggelund, Lars, Dyrhol-Riise, Anne Margarita, Virhammar, Johan, Fällmar, David, Rostami, Elham, Kumlien, Eva, Blennow, Kaj, Zetterberg, Henrik, Tumani, Hayrettin, Sacco, Simona, Green, Ari J., Otto, Markus, Kuhle, Jens, Ornello, Raffaele, Foschi, Matteo, Abu-Rumeileh, Samir

“…Background and aims To investigate the prognostic value of blood neurofilament light chain protein (NfL) levels in the acute phase of coronavirus disease 2019…”
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Quantifications of CSF Apoptotic Bodies Do Not Provide Clinical Value in Multiple Sclerosis by Masvekar, Ruturaj, Mizrahi, Jordan, Park, John, Williamson, Peter R, Bielekova, Bibiana

“…Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) that leads to the death of neurons and oligodendrocytes, which cannot be…”
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Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization by Arnatt, Christopher K, Falls, Bethany A, Yuan, Yunyun, Raborg, Thomas J, Masvekar, Ruturaj R, El-Hage, Nazira, Selley, Dana E, Nicola, Anthony V, Knapp, Pamela E, Hauser, Kurt F, Zhang, Yan

“…Modern antiretroviral therapies have provided HIV-1 infected patients longer lifespans and better quality of life. However, several neurological complications…”
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GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity by Masvekar, Ruturaj R., El-Hage, Nazira, Hauser, Kurt F., Knapp, Pamela E.

“…Infection of the CNS with HIV-1 occurs rapidly after primary peripheral infection. HIV-1 can induce a wide range of neurological deficits, collectively known…”
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Enhancing the clinical value of serum neurofilament light chain measurement by Kosa, Peter, Masvekar, Ruturaj, Komori, Mika, Phillips, Jonathan, Ramesh, Vighnesh, Varosanec, Mihael, Sandford, Mary, Bielekova, Bibiana

“…BACKGROUNDSerum neurofilament light chain (sNFL) is becoming an important biomarker of neuro-axonal injury. Though sNFL correlates with CSF NFL (cNFL), 40% to…”
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Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: evidence for sex-related effects by Hahn, Yun Kyung, Masvekar, Ruturaj R, Xu, Ruqiang, Hauser, Kurt F, Knapp, Pamela E

“…The NeuN antibody has been widely used to identify and quantify neurons in normal and disease situations based on binding to a nuclear epitope in most types of…”
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Superiority of Serum NFL in Predicting Multiple Sclerosis Severity (P2-4.003) by Kosa, Peter, Masvekar, Ruturaj, Komori, Mika, Phillips, Jonathan, Ramesh, Vighnesh, Varosanec, Mihael, Sandford, Mary, Bielekova, Bibiana

“…Abstract only…”
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Molecular‐based diagnosis of multiple sclerosis and its progressive stage by Barbour, Christopher, Kosa, Peter, Komori, Mika, Tanigawa, Makoto, Masvekar, Ruturaj, Wu, Tianxia, Johnson, Kory, Douvaras, Panagiotis, Fossati, Valentina, Herbst, Ronald, Wang, Yue, Tan, Keith, Greenwood, Mark, Bielekova, Bibiana

“…Objective Biomarkers aid diagnosis, allow inexpensive screening of therapies, and guide selection of patient‐specific therapeutic regimens in most internal…”
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Combinatorial CNS Cell-Specific CSF Biomarkers for Multiple Sclerosis (P1.390) by Masvekar, Ruturaj, Bielekova, Bibiana, Kosa, Peter, Fosatti, Valentina

“…Abstract only…”
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Neurofilament light chain in cerebrospinal fluid as a novel biomarker in evaluating both clinical severity and therapeutic response in Niemann-Pick disease type C1 by Agrawal, Neena, Farhat, Nicole Y., Sinaii, Ninet, Do, An Dang, Xiao, Changrui, Berry-Kravis, Elizabeth, Bianconi, Simona, Masvekar, Ruturaj, Bielekova, Bibiana, Solomon, Beth, Porter, Forbes D.

“…Niemann-Pick disease type C1 (NPC1) is a neurodegenerative lysosomal disorder caused by pathogenic variants in NPC1. Disease progression is monitored using the…”
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Adjusting neurofilament light levels using an MRI-based estimate of total axonal bulk improves its prediction of MS progression (P5.2-004) by Phillips, Jonathan, Masvekar, Ruturaj, Kosa, Peter, Jackson, Kayla, Weideman, Ann, Bielekova, Bibiana

“…Abstract only…”
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Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity by Masvekar, Ruturaj, Wu, Tianxia, Kosa, Peter, Barbour, Christopher, Fossati, Valentina, Bielekova, Bibiana

“…Once multiple sclerosis (MS) reaches the progressive stage, immunomodulatory treatments have limited efficacy. This suggests that processes other than…”
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Drug library screen identifies inhibitors of toxic astrogliosis by Masvekar, Ruturaj, Kosa, Peter, Barbour, Christopher, Milstein, Joshua L, Bielekova, Bibiana

“…•CSF SERPINA3 is a reliable pharmacodynamic marker of toxic astrogliosis in multiple sclerosis.•Inhibitors of pathways related to the ER stress (proteasome,…”
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Idebenone does not inhibit disability progression in primary progressive MS by Kosa, Peter, Wu, Tianxia, Phillips, Jonathan, Leinonen, Mika, Masvekar, Ruturaj, Komori, Mika, Wichman, Alison, Sandford, Mary, Bielekova, Bibiana

“…•Idebenone is well-tolerated over two-year extended use.•Idebenone did not inhibit disability accumulation in a two-year baseline-versus treatment…”
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