Search Results - "Masumoto, Shuji"
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Catalytic Enantioselective Strecker Reaction of Ketoimines
Published in Journal of the American Chemical Society (14-05-2003)“…A new method for the catalytic enantioselective Strecker reaction (cyanation) of N-diphenylphosphinoyl ketoimines is described. The asymmetric catalyst is a…”
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Design, synthesis and structure–activity relationships of novel benzoxazolone derivatives as 18kDa translocator protein (TSPO) ligands
Published in Bioorganic & medicinal chemistry (01-09-2012)“…Benzoxazolone derivatives were designed and synthesized as novel TSPO ligands. In view of initial SAR study, we selected compound 14 as lead compound. Further…”
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Catalytic asymmetric synthesis of ( S)-oxybutynin and a versatile intermediate for antimuscarinic agents
Published in Tetrahedron (08-11-2004)“…A practical synthesis of ( S)-oxybutynin, a muscarinic receptor antagonist, using catalytic enantioselective cyanosilylation of cyclohexyl phenyl ketone ( 9a )…”
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Studies toward practical synthesis of (20 S)-camptothecin family through catalytic enantioselective cyanosilylation of ketones: improved catalyst efficiency by ligand-tuning
Published in Tetrahedron letters (15-04-2002)“…Enantioselective catalyst efficiency for the synthesis of the camptothecin family was improved through ligand-tuning. Key intermediates of two convergent…”
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Rat leucine-rich protein binds and activates the promoter of the beta isoform of Ca2+/calmodulin-dependent protein kinase II gene
Published in Neuroscience research (01-05-2007)“…We previously found the neuronal cell-type specific promoter and binding partner of the beta isoform of Ca(2+)/calmodulin-dependent protein kinase II (beta CaM…”
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Rat leucine-rich protein binds and activates the promoter of the β isoform of Ca 2+/calmodulin-dependent protein kinase II gene
Published in Neuroscience research (01-05-2007)“…We previously found the neuronal cell-type specific promoter and binding partner of the β isoform of Ca 2+/calmodulin-dependent protein kinase II (β CaM kinase…”
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Identification of a Novel Benzoxazolone Derivative as a Selective, Orally Active 18 kDa Translocator Protein (TSPO) Ligand
Published in Journal of medicinal chemistry (24-10-2013)“…Optimization of the pharmacokinetic properties for a series of benzoxazolone derivatives led to the identification of 9b, which showed anxiolytic effect in a…”
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Synthesis of Unsymmetrically Substituted Antimony(V) Tetraphenylporphyrins
Published in Bulletin of the Chemical Society of Japan (01-03-1999)“…The following nine unsymmetrically axially substituted antimony(V) tetraphenylporphyrins with an antimony–carbon bond or an antimony–fluorine bond were…”
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Design, synthesis and structure―activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands
Published in Bioorganic & medicinal chemistry (15-09-2012)“…Selective 18 kDa translocator protein (TSPO) ligands are expected to be therapeutic agents with a wide spectrum of action on psychiatric disorders and fewer…”
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Design, synthesis and structure-activity relationship of novel tricyclic benzimidazolone derivatives as potent 18 kDa translocator protein (TSPO) ligands
Published in Bioorganic & medicinal chemistry (01-03-2013)“…The 18 kDa translocator protein (TSPO) was identified as a discrete receptor for diazepam (1). Since TSPO in the central nervous system (CNS) is believed to…”
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Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT1A weak partial agonistic activity showing the antidepressant-like effect
Published in Bioorganic & medicinal chemistry (01-01-2017)“…[Display omitted] We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT1A receptor weak…”
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Design, synthesis and structure–activity relationship of novel tricyclic benzimidazolone derivatives as potent 18kDa translocator protein (TSPO) ligands
Published in Bioorganic & medicinal chemistry (01-03-2013)“…We obtained dihydroimidazoquinolinone derivatives with potent affinity for TSPO (subnanomolar Ki values), by conversion of the benzoxazolone skeleton to a…”
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A practical synthesis of ( S)-oxybutynin
Published in Tetrahedron letters (25-11-2002)“…( S)-Oxybutynin, an important drug acting as muscarinic receptor antagonist, was practically synthesized using catalytic enantioselective cyanosilylation of…”
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Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT 1A weak partial agonistic activity showing the antidepressant-like effect
Published in Bioorganic & medicinal chemistry (01-01-2017)“…We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT receptor weak partial agonistic…”
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Practical synthesis of chiral ligands for catalytic enantioselective cyanosilylation of ketones
Published in Tetrahedron letters (15-04-2002)“…A practical and more environmentally benign synthetic route of chiral ligands that are useful for catalytic enantioselective cyanosilylation of ketones is…”
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Tricyclic Indole-2-carboxylic Acids: Highly in Vivo Active and Selective Antagonists for the Glycine Binding Site of the NMDA Receptor
Published in Journal of medicinal chemistry (27-02-2003)“…A series of tricyclic indole-2-carboxylic acid derivatives were synthesized and evaluated by the radioligand binding assay and the anticonvulsant effects in…”
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Synthesis and Electrochemistry of Tetraphenylporphyrins Containing an Antimony−Carbon σ-Bond
Published in Inorganic chemistry (11-09-1996)“…The following five antimony(V) tetraphenylporphyrins with σ-bonded antimony−carbon bonds were synthesized: [(TPP)Sb(CH3)2]+PF6 -, [(TPP)Sb(OCH3)(OH)]+PF6 -,…”
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