Search Results - "Masuda, Tomonori"
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Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway
Published in Gastroenterology (New York, N.Y. 1943) (01-08-2022)“…Pancreatic ductal adenocarcinoma (PDAC) arises from several types of premalignant lesions, including intraductal tubulopapillary neoplasm (ITPN); however, the…”
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SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice
Published in Gastroenterology (New York, N.Y. 1943) (01-08-2020)“…SETDB1, a histone methyltransferase that trimethylates histone H3 on lysine 9, promotes development of several tumor types. We investigated whether SETDB1…”
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Brg1 is required to maintain colorectal cancer stem cells
Published in The Journal of pathology (01-11-2021)“…Tumor cells capable of self‐renewal and continuous production of progeny cells are called tumor stem cells (TSCs) and are considered to be potential…”
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Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis
Published in The Journal of clinical investigation (15-09-2023)“…RECK is downregulated in various human cancers; however, how RECK inactivation affects carcinogenesis remains unclear. We addressed this issue in a pancreatic…”
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JNK pathway plays a critical role for expansion of human colorectal cancer in the context of BRG1 suppression
Published in Cancer science (01-10-2022)“…Tumor stem cells (TSCs), capable of self‐renewal and continuous production of progeny cells, could be potential therapeutic targets. We have recently reported…”
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Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway
Published in Oncogene (23-06-2023)“…Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. We previously reported that chromatin remodeler Brg1 is essential for acinar cell-derived…”
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Simultaneous activation of Kras–Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway
Published in The Journal of pathology (01-08-2023)“…Biliary tract cancer (BTC) has poor prognosis. The Notch receptor is aberrantly expressed in extrahepatic cholangiocarcinoma (eCCA). However, the role of Notch…”
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Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice
Published in Cancer research (Chicago, Ill.) (03-05-2022)“…Biliary cancer has long been known to carry a poor prognosis, yet the molecular pathogenesis of carcinoma of the extrahepatic biliary system and its precursor…”
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Abstract C37: Setdb1 is required for formation of pancreatic ductal adenocarcinoma by inhibiting apoptosis through regulation of p53 expression
Published in Cancer research (Chicago, Ill.) (15-12-2019)“…Abstract Epigenetics is one of the representative mutation signatures in human pancreatic ductal adenocarcinoma (PDAC). Histone modification, one group of…”
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THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer
Published in Nature communications (25-09-2023)“…Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness of colorectal cancers (CRC),…”
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Abstract 951: Setdb1 deletion protects against formation of pancreatic ductal adenocarcinoma through inducing apoptosis and upregulating p53 expression
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Abstract One group of epigenetic regulators known to be altered in cancer development is histone modification. Setdb1, a histone methyltransferase that…”
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Epithelial EP4 plays an essential role in maintaining homeostasis in colon
Published in Scientific reports (23-10-2019)“…Colonic epithelial cells comprise the mucosal barrier, and their dysfunction promotes microbial invasion from the gut lumen and induces the development of…”
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Frequency stabilization of a visible laser diode to an enhanced saturated absorption signal of molecular iodine in an external cavity
Published in Japanese Journal of Applied Physics (01-11-1997)“…A small saturated absorption signal of molecular iodine was enhanced by placing an iodine cell inside an external cavity. Using the third derivative signal of…”
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Magnetization transfer contrast imaging of the cervical spine at 0.3 T
Published in Journal of computer assisted tomography (01-11-1994)“…We assessed the efficacy of magnetization transfer contrast (MTC) imaging of the cervical spine in conjunction with a gradient recalled echo (GRE) technique…”
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