Search Results - "Masuda, Nobuhisa"

Azithromycin Exhibits Activity Against Pseudomonas aeruginosa in Chronic Rat Lung Infection Model by Kumar, Manoj, Rao, Madhvi, Mathur, Tarun, Barman, Tarani Kanta, Joshi, Vattan, Chaira, Tridib, Singhal, Smita, Pandya, Manisha, Al Khodor, Souhaila, Upadhyay, Dilip J, Masuda, Nobuhisa

“…forms biofilms in the lungs of chronically infected cystic fibrosis patients, which are tolerant to both the treatment of antibiotics and the host immune…”
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Regulatory network of acid resistance genes in Escherichia coli by Masuda, Nobuhisa, Church, George M.

“…Summary Overexpression of the response regulator EvgA confers an acid‐resistant phenotype to exponentially growing Escherichia coli. This acid resistance is…”
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Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in Pseudomonas aeruginosa by MASUDA, Nobuhisa, SAKAGAWA, Eiko, OHYA, Satoshi, GOTOH, Naomasa, TSUJIMOTO, Hideto, NISHINO, Takeshi

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Escherichia coli Gene Expression Responsive to Levels of the Response Regulator EvgA by Masuda, Nobuhisa, Church, George M

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Characterization of EvgAS-YdeO-GadE Branched Regulatory Circuit Governing Glutamate-Dependent Acid Resistance in Escherichia coli by ZHUO MA, MASUDA, Nobuhisa, FOSTER, John W

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Potent In Vitro Activity of Tomopenem (CS-023) against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa by KOGA, Tetsufumi, MASUDA, Nobuhisa, KAKUTA, Masayo, NAMBA, Eiko, SUGIHARA, Chika, FUKUOKA, Takashi

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Contribution of the MexX-MexY-OprM Efflux System to Intrinsic Resistance in Pseudomonas aeruginosa by MASUDA, N, SAKAGAWA, E, OHYA, S, GOTOH, N, TSUJIMOTO, H, NISHINO, T

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Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196 by Funabashi, Masanori, Nonaka, Koichi, Yada, Chieko, Hosobuchi, Masahiko, Masuda, Nobuhisa, Shibata, Tomoyuki, Van Lanen, Steven G

“…A-500359s, produced by Streptomyces griseus SANK60196, are inhibitors of bacterial phospho- N -acetylmuramyl-pentapeptide translocase. They are composed of…”
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Affinity of Tomopenem (CS-023) for Penicillin-Binding Proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by KOGA, Tetsufumi, SUGIHARA, Chika, KAKUTA, Masayo, MASUDA, Nobuhisa, NAMBA, Eiko, FUKUOKA, Takashi

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In Vitro and In Vivo Antibacterial Activities of CS-023 (RO4908463), a Novel Parenteral Carbapenem by KOGA, Tetsufumi, ABE, Tomomi, SHIBAYAMA, Takahiro, MATSUSHITA, Yoko, HIROTA, Takashi, OHYA, Satoshi, UTSUI, Yukio, FUKUOKA, Takashi, KUWAHARA, Syogo, INOUE, Harumi, TAKENOUCHI, Takashi, KITAYAMA, Akiko, YOSHIDA, Tatsuhiko, MASUDA, Nobuhisa, SUGIHARA, Chika, KAKUTA, Masayo, NAKAGAWA, Miyuki

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A motif co-occurrence approach for genome-wide prediction of transcription-factor-binding sites in Escherichia coli by Bulyk, Martha L, McGuire, Abigail M, Masuda, Nobuhisa, Church, George M

“…Various computational approaches have been developed for predicting cis-regulatory DNA elements in prokaryotic genomes. We describe a novel method for…”
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Hypersusceptibility of the Pseudomonas aeruginosa nfxB Mutant to β-Lactams Due to Reduced Expression of the AmpC β-Lactamase by MASUDA, Nobuhisa, SAKAGAWA, Eiko, OHYA, Satoshi, GOTOH, Naomasa, NISHINO, Takeshi

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In Vitro and In Vivo Activities of DS86760016, a Novel Leucyl-tRNA Synthetase Inhibitor for Gram-Negative Pathogens by Purnapatre, Kedar P, Rao, Madhvi, Pandya, Manisha, Khanna, Alka, Chaira, Tridib, Bambal, Ramesh, Upadhyay, Dilip J, Masuda, Nobuhisa

“…The emergence of multidrug-resistant (MDR) Gram-negative bacilli is a major concern in the treatment of nosocomial infections. Antibacterial agents with novel…”
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In Vitro and In Vivo Activities of DS-2969b, a Novel GyrB Inhibitor, against Clostridium difficile by Mathur, Tarun, Barman, Tarani Kanta, Kumar, Manoj, Singh, Diksha, Kumar, Ram, Khera, Manoj Kumar, Yamada, Makiko, Inoue, Shin-Ichi, Upadhyay, Dilip Jatashankar, Masuda, Nobuhisa

“…DS-2969b is a novel GyrB inhibitor that is currently under clinical development for the treatment of infection (CDI). In this study, the and activities of…”
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Phase 1 Study To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Oral Doses of DS-2969b, a Novel GyrB Inhibitor, in Healthy Subjects by Vandell, Alexander G, Inoue, Satoshi, Dennie, Justin, Nagasawa, Yasuo, Gajee, Roohi, Pav, Joe, Zhang, George, Zamora, Cynthia, Masuda, Nobuhisa, Senaldi, Giorgio

“…DS-2969b is a novel GyrB inhibitor in development for the treatment of infection (CDI). The aim of this study was to assess the safety, tolerability,…”
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Novel FtsZ inhibitor with potent activity against Staphylococcus aureus by Kumar, Manoj, Mathur, Tarun, Barman, Tarani Kanta, Chaira, Tridib, Kumar, Ram, Joshi, Vattan, Pandya, Manisha, Sharma, Lalima, Fujii, Kunihiko, Bandgar, Mahadev, Jadhav, Balasaheb, Bambal, Ramesh, Upadhyay, Dilip, Masuda, Nobuhisa, Verma, Ashwani Kumar, Bhatnagar, Pradip Kumar

“…Abstract Objectives FtsZ is an essential bacterial protein and an unexplored target for the development of antibacterial drugs. The development of a novel…”
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In Vitro and In Vivo Activities of DS-2969b, a Novel GyrB Inhibitor, and Its Water-Soluble Prodrug, DS11960558, against Methicillin-Resistant Staphylococcus aureus by Barman, Tarani Kanta, Kumar, Manoj, Mathur, Tarun, Namba, Eiko, Singh, Diksha, Chaira, Tridib, Kurosaka, Yuichi, Yamada, Makiko, Upadhyay, Dilip Jatashankar, Masuda, Nobuhisa

“…DS-2969b is a novel GyrB inhibitor under clinical development. In this study, the activity of DS-2969b and the activities of DS-2969b and its water-soluble…”
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DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa by Kumar, Manoj, Rao, Madhvi, Purnapatre, Kedar P, Barman, Tarani Kanta, Joshi, Vattan, Kashyap, Amuliya, Chaira, Tridib, Bambal, Ramesh B, Pandya, Manisha, Khodor, Souhaila Al, Upadhyay, Dilip J, Masuda, Nobuhisa

“…DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage. DS86760016 showed potent activity against extended-spectrum…”
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A Phase I, Single‐Ascending‐Dose Study in Healthy Subjects to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DS‐2969b, a Novel GyrB Inhibitor by Dennie, Justin, Vandell, Alexander G., Inoue, Satoshi, Gajee, Roohi, Pav, Joseph, Zhang, George, Zamora, Cynthia, Masuda, Nobuhisa, Uchiyama, Minoru, Yamada, Makiko, Senaldi, Giorgio

“…DS‐2969b is a novel GyrB inhibitor in development for the treatment of Clostridium difficile infection. The aim of this study was to assess the safety,…”
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Effect of DS-2969b, a novel GyrB inhibitor, on rat and monkey intestinal microbiota by Kumar, Manoj, Mathur, Tarun, Joshi, Vattan, Upadhyay, Dilip J., Inoue, Shin-ichi, Masuda, Nobuhisa

“…DS-2969b, a novel GyrB inhibitor, transiently and reversibly altered the counts of limited intestinal microbiota at around 10 μg/g of faecal levels in rats and…”
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