Search Results - "Masuda, Kazufumi"

Bis(hinokitiolato)zinc complex ([Zn(hkt)2]) activates Akt/protein kinase B independent of insulin signal transduction by Naito, Yuki, Yoshikawa, Yutaka, Masuda, Kazufumi, Yasui, Hiroyuki

“…Since many Zn complexes have been developed to enhance the insulin-like activity and increase the exposure and residence of Zn in the animal body, these…”
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Noninvasive analysis of volatile biomarkers in human emanations for health and early disease diagnosis by Kataoka, Hiroyuki, Saito, Keita, Kato, Hisato, Masuda, Kazufumi

“…Early disease diagnosis is crucial for human healthcare and successful therapy. Since any changes in homeostatic balance can alter human emanations, the…”
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Structural Requirements for Potent Direct Inhibition of Human Cytochrome P450 1A1 by Cannabidiol: Role of Pentylresorcinol Moiety by Yamaori, Satoshi, Okushima, Yoshimi, Masuda, Kazufumi, Kushihara, Mika, Katsu, Takashi, Narimatsu, Shizuo, Yamamoto, Ikuo, Watanabe, Kazuhito

“…Our recent work has shown that cannabidiol (CBD) exhibits the most potent direct inhibition of human cytochrome P450 1A1 (CYP1A1) among the CYP enzymes…”
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Antibacterial Activity of Membrane-Permeabilizing Bactericidal Cyclodextrin Derivatives by Yamamura, Hatsuo, Hagiwara, Tatsuya, Hayashi, Yuma, Osawa, Kayo, Kato, Hisato, Katsu, Takashi, Masuda, Kazufumi, Sumino, Ayumi, Yamashita, Hayato, Jinno, Ryo, Abe, Masayuki, Miyagawa, Atsushi

“…Antimicrobial peptides that act by disrupting bacterial membranes are attractive agents for treating drug-resistant bacteria. This study investigates a…”
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Characterization of marmoset CYP2B6: cDNA cloning, protein expression and enzymatic functions by Mayumi, Kei, Hanioka, Nobumitsu, Masuda, Kazufumi, Koeda, Akiko, Naito, Shinsaku, Miyata, Atsuro, Narimatsu, Shizuo

“…The common marmoset is a promising species for evaluating the safety of drug candidates. To further understand the capacity for drug metabolism in marmosets, a…”
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Regio- and stereoselective oxidation of propranolol enantiomers by human CYP2D6, cynomolgus monkey CYP2D17 and marmoset CYP2D19 by Narimatsu, Shizuo, Nakata, Toshiyuki, Shimizudani, Takeshi, Nagaoka, Kenjiro, Nakura, Hironori, Masuda, Kazufumi, Katsu, Takashi, Koeda, Akiko, Naito, Shinsaku, Yamano, Shigeru, Miyata, Atsuro, Hanioka, Nobumitsu

“…HPLC chromatograms showing the oxidation of PL enantiomers by primates recombinant enzymes. Toxic and pharmacokinetic profiles of drug candidates are evaluated…”
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Simultaneous Measurements of K+ and Calcein Release from Liposomes and the Determination of Pore Size Formed in a Membrane by KATSU, Takashi, IMAMURA, Tomonori, KOMAGOE, Keiko, MASUDA, Kazufumi, MIZUSHIMA, Tohru

“…The changes induced by biologically active substances in the permeability to K+ and calcein of liposomes composed of egg phosphatidylcholine and cholesterol…”
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Precise Size Determination of Amphotericin B and Nystatin Channels Formed in Erythrocyte and Liposomal Membranes Based on Osmotic Protection Experiments by KATSU, Takashi, OKADA, Shiho, IMAMURA, Tomonori, KOMAGOE, Keiko, MASUDA, Kazufumi, INOUE, Tsuyoshi, NAKAO, Satoshi

“…The colloid osmotic nature of the cell lysis can be prevented by adding osmotic protectants of appropriate sizes to the outer medium. We introduced inorganic…”
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The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol by Narimatsu, Shizuo, Kazamori, Daichi, Masuda, Kazufumi, Katsu, Takashi, Funae, Yoshihiko, Naito, Shinsaku, Nakura, Hironori, Yamano, Shigeru, Hanioka, Nobumitsu

“…The capacity to oxidize bufuralol (BF) and dextromethorphan (DEX) was compared kinetically between human CYP2D6 and four rat CYP2D (CYP2D1, -2D2, -2D3 and…”
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Oxidation of 5-methoxy- N, N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymes by Narimatsu, Shizuo, Yonemoto, Rei, Masuda, Kazufumi, Katsu, Takashi, Asanuma, Masato, Kamata, Tooru, Katagi, Munehiro, Tsuchihashi, Hitoshi, Kumamoto, Takuya, Ishikawa, Tsutomu, Naito, Shinsaku, Yamano, Shigeru, Hanioka, Nobumitsu

“…The oxidative metabolism of 5-methoxy- N, N-diisopropyltryptamine (5-MeO-DIPT), a tryptamine-type designer drug, was studied using rat liver microsomal…”
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Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes by Hanioka, Nobumitsu, Yamamoto, Maki, Iwabu, Hiroyuki, Jinno, Hideto, Tanaka-Kagawa, Toshiko, Naito, Shinsaku, Shimizu, Takefumi, Masuda, Kazufumi, Katsu, Takashi, Narimatsu, Shizuo

“…Cytochrome P450 2E1 (CYP2E1) is an enzyme of major toxicological interest because it metabolizes various drugs, precarcinogens and solvents to reactive…”
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Cloning of a cDNA encoding a novel marmoset CYP2C enzyme, expression in yeast cells and characterization of its enzymatic functions by Narimatsu, Shizuo, Torigoe, Fumihiro, Tsuneto, Yumi, Saito, Keita, Hanioka, Nobumitsu, Masuda, Kazufumi, Katsu, Takashi, Yamamoto, Shigeo, Yamano, Shigeru, Baba, Takahiko, Miyata, Atsuro

“…We cloned a cDNA encoding a novel CYP2C enzyme, called P450 M-2C, from a marmoset liver. The deduced amino acid sequence showed high identities to those of…”
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Tris(2-ethylhexyl)phosphine oxide as an effective solvent mediator for constructing a serotonin-selective membrane electrode by Ueda, Keisuke, Yonemoto, Rei, Komagoe, Keiko, Masuda, Kazufumi, Hanioka, Nobumitsu, Narimatsu, Shizuo, Katsu, Takashi

“…A series of solvent mediators containing a phosphoryl (P O) group, such as tris(2-ethylhexyl)phosphate, bis(2-ethylhexyl) 2-ethylhexylphosphonate, 2-ethylhexyl…”
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Change in enantioselectivity in bufuralol 1″-hydroxylation by the substitution of phenylalanine-120 by alanine in cytochrome P450 2D6 by Masuda, Kazufumi, Tamagake, Keietsu, Okuda, Yukie, Torigoe, Fumihiro, Tsuzuki, Daisuke, Isobe, Takashi, Hichiya, Hiroyuki, Hanioka, Nobumitsu, Yamamoto, Shigeo, Narimatsu, Shizuo

“…The functional roles of phenylalanine at position 120 in drug oxidation by cytochrome P450 2D6 (CYP2D6) were examined using a yeast cell expression system and…”
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Extensive improvement of oral bioavailability of mebendazole, a brick dust, by polymer-containing SNEDDS preparation: Disruption of high crystallinity by utilizing its counter ion by Sumimoto, Yusuke, Okawa, Shinya, Inoue, Tomoya, Masuda, Kazufumi, Maruyama, Masato, Higaki, Kazutaka

“…[Display omitted] Poorly water-soluble and poorly lipid-soluble drugs are called as “brick dust” and it is very hard for them to be formulated as some dosage…”
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Improvement of lipid solubility and oral bioavailability of a poorly water- and poorly lipid-soluble drug, rebamipide, by utilizing its counter ion and SNEDDS preparation by Okawa, Shinya, Sumimoto, Yusuke, Masuda, Kazufumi, Ogawara, Ken-ichi, Maruyama, Masato, Higaki, Kazutaka

“…Among drugs in development and/or in market, there are poorly water-soluble and poorly lipid-soluble compounds. Rebamipide, classified into BCS class IV, is…”
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Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide by Itoh, Hisataka, Yamashita, Naho, Kamijo, Shinobu, Masuda, Kazufumi, Kato, Hisato, Yamaori, Satoshi

“…Cytochrome P450 4A11 (CYP4A11) has many endogenous and exogenous compounds containing a carboxyl group in their structure as substrates. If drugs with this…”
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Structure-activity relationship of porphyrin-induced photoinactivation with membrane function in bacteria and erythrocytes by Kato, Hisato, Komagoe, Keiko, Inoue, Tsuyoshi, Masuda, Kazufumi, Katsu, Takashi

“…We analyzed the structure-activity relationship of porphyrins with the photoinactivation of membrane function in bacteria and erythrocytes. The porphyrins…”
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Analysis of heterocyclic amines in hair by on-line in-tube solid-phase microextraction coupled with liquid chromatography−tandem mass spectrometry by Kataoka, Hiroyuki, Inoue, Tsutomu, Saito, Keita, Kato, Hisato, Masuda, Kazufumi

“…Mutagenic and carcinogenic heterocyclic amines are accumulated in the hair of smoker. •On-line in-tube solid-phase microextraction of heterocyclic amines was…”
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Improvement of Oral Bioavailability of N-251, a Novel Antimalarial Drug, by Increasing Lymphatic Transport with Long-Chain Fatty Acid-Based Self-Nanoemulsifying Drug Delivery System by Imada, Chikako, Takahashi, Takuma, Kuramoto, Makoto, Masuda, Kazufumi, Ogawara, Ken-ichi, Sato, Akira, Wataya, Yusuke, Kim, Hye-Sook, Higaki, Kazutaka

“…Purpose The objective of this study was to improve the absorption behavior of N-251, a novel antimalarial drug, by preparing an appropriate…”
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