Search Results - "Masuda, Isao"

A tRNA modification pattern that facilitates interpretation of the genetic code by Masuda, Isao, Hou, Ya-Ming

“…Interpretation of the genetic code from triplets of nucleotides to amino acids is fundamental to life. This interpretation is achieved by cellular tRNAs, each…”
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Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation by Demo, Gabriel, Gamper, Howard B., Loveland, Anna B., Masuda, Isao, Carbone, Christine E., Svidritskiy, Egor, Hou, Ya-Ming, Korostelev, Andrei A.

“…Frameshifting of mRNA during translation provides a strategy to expand the coding repertoire of cells and viruses. How and where in the elongation cycle…”
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Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA by Gamper, Howard, Li, Haixing, Masuda, Isao, Miklos Robkis, D., Christian, Thomas, Conn, Adam B., Blaha, Gregor, Petersson, E. James, Gonzalez, Ruben L., Hou, Ya-Ming

“…While genome recoding using quadruplet codons to incorporate non-proteinogenic amino acids is attractive for biotechnology and bioengineering purposes, the…”
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Protocol to identify the core gene supported by an essential gene in E. coli bacteria using a genome-wide suppressor screen by Masuda, Isao, Hou, Ya-Ming

“…We describe here a genome-wide screening approach to identify the most critical core reaction among a network of many that are supported by an essential gene…”
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tRNA methylation: An unexpected link to bacterial resistance and persistence to antibiotics and beyond by Hou, Ya‐Ming, Masuda, Isao, Foster, Leonard J.

“…A major threat to public health is the resistance and persistence of Gram‐negative bacteria to multiple drugs during antibiotic treatment. The resistance is…”
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Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression by Masuda, Isao, Hwang, Jae-Yeon, Christian, Thomas, Maharjan, Sunita, Mohammad, Fuad, Gamper, Howard, Buskirk, Allen R, Hou, Ya-Ming

“…N 1 -methylation of G37 is required for a subset of tRNAs to maintain the translational reading-frame. While loss of m 1 G37 increases ribosomal +1…”
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Selective terminal methylation of a tRNA wobble base by Masuda, Isao, Takase, Ryuichi, Matsubara, Ryuma, Paulines, Mellie June, Gamper, Howard, Limbach, Patrick A, Hou, Ya-Ming

“…Abstract Active tRNAs are extensively post-transcriptionally modified, particularly at the wobble position 34 and the position 37 on the 3′-side of the…”
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Structural basis for methyl-donor–dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD by Ito, Takuhiro, Masuda, Isao, Yoshida, Ken-ichi, Goto-Ito, Sakurako, Sekine, Shun-ichi, Suh, Se Won, Hou, Ya-Ming, Yokoyama, Shigeyuki

“…The deep trefoil knot architecture is unique to the SpoU and tRNA methyltransferase D (TrmD) (SPOUT) family of methyltransferases (MTases) in all three domains…”
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Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes by Masuda, Isao, Koike, Masato, Nakashima, Shohei, Mizutani, Yu, Ozawa, Yusuke, Watanabe, Kenji, Sawada, Yoko, Sugiyama, Hiroshi, Sugimoto, Atsushi, Nojiri, Hidetoshi, Sashihara, Koichi, Yokote, Koutaro, Shimizu, Takahiko

“…Apples are well known to have various benefits for the human body. Procyanidins are a class of polyphenols found in apples that have demonstrated effects on…”
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Codon-Specific Translation by m1G37 Methylation of tRNA by Hou, Ya-Ming, Masuda, Isao, Gamper, Howard

“…Although the genetic code is degenerate, synonymous codons for the same amino acid are not translated equally. Codon-specific translation is important for…”
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Kinetic Analysis of tRNA Methyltransferases by Hou, Ya-Ming, Masuda, Isao

“…Transfer RNA (tRNA) molecules contain many chemical modifications that are introduced after transcription. A major form of these modifications is methyl…”
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tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance by Masuda, Isao, Matsubara, Ryuma, Christian, Thomas, Rojas, Enrique R, Yadavalli, Srujana S, Zhang, Lisheng, Goulian, Mark, Foster, Leonard J, Huang, Kerwyn Casey, Hou, Ya-Ming

“…Gram-negative bacteria are intrinsically resistant to drugs because of their double-membrane envelope structure that acts as a permeability barrier and as an…”
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Extensive frameshift at all AGG and CCC codons in the mitochondrial cytochrome c oxidase subunit 1 gene of Perkinsus marinus (Alveolata; Dinoflagellata) by Masuda, Isao, Matsuzaki, Motomichi, Kita, Kiyoshi

“…Diverse mitochondrial (mt) genetic systems have evolved independently of the more uniform nuclear system and often employ modified genetic codes. The…”
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The Temperature Sensitivity of a Mutation in the Essential tRNA Modification Enzyme tRNA Methyltransferase D (TrmD) by Masuda, Isao, Sakaguchi, Reiko, Liu, Cuiping, Gamper, Howard, Hou, Ya-Ming

“…Although temperature-sensitive (ts) mutations of TrmD exist, deficient in converting G37- to m1G37-tRNA, the basis of their phenotype is unknown. Results: The…”
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The UGG Isoacceptor of tRNAPro Is Naturally Prone to Frameshifts by Gamper, Howard B, Masuda, Isao, Frenkel-Morgenstern, Milana, Hou, Ya-Ming

“…Native tRNAs often contain post-transcriptional modifications to the wobble position to expand the capacity of reading the genetic code. Some of these…”
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Maintenance of protein synthesis reading frame by EF-P and m1G37-tRNA by Gamper, Howard B., Masuda, Isao, Frenkel-Morgenstern, Milana, Hou, Ya-Ming

“…Maintaining the translational reading frame poses difficulty for the ribosome. Slippery mRNA sequences such as CC[C/U]-[C/U], read by isoacceptors of tRNA Pro…”
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Mitochondrial genomes from two red tide forming raphidophycean algae Heterosigma akashiwo and Chattonella marina var. marina by Masuda, Isao, Kamikawa, Ryoma, Ueda, Manabu, Oyama, Kenichi, Yoshimatsu, Sadaaki, Inagaki, Yuji, Sako, Yoshihiko

“…Chattonella marina (Subrahmanyan) Hara et Chihara var. marina and Heterosigma akashiwo Hada (Hada) are members of raphidophycean algae responsible for…”
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Development of a novel molecular marker on the mitochondrial genome of a toxic dinoflagellate, Alexandrium spp., and its application in single-cell PCR by Kamikawa, Ryoma, Hosoi-Tanabe, Shoko, Yoshimatsu, Sadaaki, Oyama, Kenichi, Masuda, Isao, Sako, Yoshihiko

“…Although the molecular data currently used for identifying dinoflagellates are generally limited to nuclear ribosomal RNA genes, some dinoflagellates cannot be…”
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Genetic variation in mitochondrial genes and intergenic spacer region in harmful algae Chattonella species by Kamikawa, R.(Kyoto Univ. (Japan)), Masuda, I, Oyama, K, Yoshimatsu, S, Sako, Y

“…In this study, nuclear ribosomal RNA gene internal transcribed spacer regions and the cox2–cox1 fragment of the mitochondrial (mt) genome were sequenced in 24…”
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Mitochondrial Group II Introns in the Raphidophycean Flagellate Chattonella spp. Suggest a Diatom-to- Chattonella Lateral Group II Intron Transfer by Kamikawa, Ryoma, Masuda, Isao, Demura, Mikihide, Oyama, Kenichi, Yoshimatsu, Sadaaki, Kawachi, Masanobu, Sako, Yoshihiko

“…In the cytochrome c oxidase subunit I ( cox1) gene of four raphidophycean flagellates Chattonella antiqua, C. marina, C. ovata, and C. minima we found two…”
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