Search Results - "Mastronardi, Fabrizio"

Normalization of obesity-associated insulin resistance through immunotherapy by Chan, Yin, Winer, Daniel, Engleman, Edgar, Winer, Shawn, Tsui, Hubert, Truong, Dorothy, Dorfman, Ruslan, Mastronardi, Fabrizio, Wang, Yongqian, Zielenski, Julian, Drucker, Daniel J, Bahrami, Jasmine, Dosch, H.-Michael, Maezawa, Yuko, Paltser, Geoffrey

“…In these new reports, three different research groups independently find that various T cell populations are crucial mediators of obesity-induced metabolic…”
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Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated by Mastronardi, Fabrizio G., Noor, Abdul, Wood, D. Denise, Paton, Tara, Moscarello, Mario A.

“…In previous studies, we documented increased citrullinated myelin basic protein (MBP) was present in MBP isolated from multiple sclerosis (MS) normal appearing…”
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The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis by Moscarello, Mario A, Mastronardi, Fabrizio G, Wood, D Denise

“…The pathogenesis of MS is unknown. In our studies, we have demonstrated an important role for citrullinated myelin basic protein (MBP). The accompanying loss…”
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Increased Citrullination of Histone H3 in Multiple Sclerosis Brain and Animal Models of Demyelination: A Role for Tumor Necrosis Factor-Induced Peptidylarginine Deiminase 4 Translocation by Mastronardi, Fabrizio G, Wood, D. Denise, Mei, Jiang, Raijmakers, Reinout, Tseveleki, Vivian, Dosch, Hans-Michael, Probert, Lesley, Casaccia-Bonnefil, Patrizia, Moscarello, Mario A

“…Modification of arginine residues by citrullination is catalyzed by peptidylarginine deiminases (PADs), of which five are known, generating irreversible…”
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Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis by Moscarello, Mario A, Lei, Helena, Mastronardi, Fabrizio G, Winer, Shawn, Tsui, Hubert, Li, Zhen, Ackerley, Cameron, Zhang, Li, Raijmakers, Reinout, Wood, D Denise

“…Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to…”
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Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities by Wood, Dorothy D, Ackerley, Cameron A, Brand, Ben van den, Zhang, Li, Raijmakers, Reinout, Mastronardi, Fabrizio G, Moscarello, Mario A

“…An understanding of the structure and composition of the myelin sheath is essential to understand the pathogenesis of demyelinating diseases such as multiple…”
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Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system by Musse, Abdiwahab A, Li, Zhen, Ackerley, Cameron A, Bienzle, Dorothee, Lei, Helena, Poma, Roberto, Harauz, George, Moscarello, Mario A, Mastronardi, Fabrizio G

“…Demyelination in the central nervous system is the hallmark feature in multiple sclerosis (MS). The mechanism resulting in destabilization of myelin is a…”
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Deimination restores inner retinal visual function in murine demyelinating disease by Enriquez-Algeciras, Mabel, Ding, Di, Mastronardi, Fabrizio G, Marc, Robert E, Porciatti, Vittorio, Bhattacharya, Sanjoy K

“…Progressive loss of visual function frequently accompanies demyelinating diseases such as multiple sclerosis (MS) and is hypothesized to be the result of…”
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Molecules affecting myelin stability: A novel hypothesis regarding the pathogenesis of multiple sclerosis by Mastronardi, Fabrizio G., Moscarello, Mario A.

“…In this Mini‐Review we present a new hypothesis in support of the neurodegenerative theory as a mechanism for the pathogenesis of multiple sclerosis (MS). The…”
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Attenuation of experimental autoimmune encephalomyelitis and nonimmune demyelination by IFN-beta plus vitamin B12: treatment to modify notch-1/sonic hedgehog balance by Mastronardi, Fabrizio G, Min, Weixian, Wang, Huimin, Winer, Shawn, Dosch, Michael, Boggs, Joan M, Moscarello, Mario A

“…Interferon-beta is a mainstay therapy of demyelinating diseases, but its effects are incomplete in human multiple sclerosis and several of its animal models…”
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Expression of Stathmin, a Developmentally Controlled Cytoskeleton-Regulating Molecule, in Demyelinating Disorders by Liu, Aixiao, Stadelmann, Christine, Moscarello, Mario, Bruck, Wolfgang, Sobel, Andre, Mastronardi, Fabrizio G, Casaccia-Bonnefil, Patrizia

“…Understanding the biological relevance of reexpression of developmental molecules in pathological conditions is crucial for the development of new therapies…”
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Genetic analysis of protein kinase B (AKT) in Drosophila by Staveley, Brian E., Ruel, Laurent, Jin, Jing, Stambolic, Vuk, Mastronardi, Fabrizio G., Heitzler, Pascal, Woodgett, James R., Manoukian, Armen S.

“…The decision between survival and death is an important aspect of cellular regulation during development and malignancy. Central to this regulation is the…”
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Changed histone acetylation patterns in normal-appearing white matter and early multiple sclerosis lesions by Pedre, Xiomara, Mastronardi, Fabrizio, Bruck, Wolfgang, López-Rodas, Gerardo, Kuhlmann, Tanja, Casaccia, Patrizia

“…The epigenetic identity of oligodendrocytes is modulated by posttranslational modifications of histones. Acetylation of histone H3 results from the balance…”
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Co-localization of Patched and activated Sonic hedgehog to lysosomes in neurons by Mastronardi, Fabrizio G, Dimitroulakos, Jim, Kamel-Reid, Suzanne, Manoukian, Armen S

“…We demonstrate co-localization of the Patched 1 (Ptcl) receptor and its ligand sonic hedgehog (Shh) in lysosomes suggests an intracellular sorting mechanism…”
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The amount of sonic hedgehog in multiple sclerosis white matter is decreased and cleavage to the signaling peptide is deficient by Mastronardi, Fabrizio G, daCruz, Luis AG, Wang, Huimin, Boggs, Joan, Moscarello, Mario A

“…We have demonstrated that sonic hedgehog (Shh), vital for oligodendrocyte development, is present in both gray and white matter of normal human brain. Both the…”
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Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis by Casaccia-Bonnefil, Patrizia, Pandozy, Giovanna, Mastronardi, Fabrizio

“…The evidence suggesting a role of epigenetics in the definition of complex trait diseases is rapidly increasing. The gender prevalence of multiple sclerosis,…”
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Corrigendum to “Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: A contribution to the current debate on disease pathogenesis” [Prog. Neurobiol. 86 (2008) 406–416] by Casaccia-Bonnefil, Patrizia, Pandozy, Giovanna, Mastronardi, Fabrizio

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Development and characterization of a novel hybrid tissue engineering-based scaffold for spinal cord injury repair by Silva, Nuno A, Salgado, Antonio J, Sousa, Rui A, Oliveira, Joao T, Pedro, Adriano J, Leite-Almeida, Hugo, Cerqueira, Rui, Almeida, Armando, Mastronardi, Fabrizio, Mano, João F, Neves, Nuno M, Sousa, Nuno, Reis, Rui L

“…Spinal cord injury (SCI) represents a significant health and social problem, and therefore it is vital to develop novel strategies that can specifically target…”
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GSK-3 Spatial Regulation Has an Essential Role in Lenalidomide Activity and Represents a Biomarker of Clinical Response in CLL by Trudel, Suzanne, Scanga, Sam, Mastronardi, Fabrizio G, Wei, Ellen Nong, Mercurio, Frank, Lopez-Girona, Antonia, Gaidarova, Svetlana, Webb, David R., Chen, Christine, Stewart, Keith, Manoukian, Armen S

“…Abstract 1793 Thalidomide (THAL) and IMID® immunomodulary drugs lenalidomide (LEN) and (POM) have proven beneficial in the treatment of a variety of…”
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The partial characterization of myelin basic protein from common goldfish (Carassius auratus L.) brain myelin by Mastronardi, Fabrizio G

“…A method of extraction of myelin from goldfish brain was developed, in order to extract myelin basic protein (MBP). The myelin proteins of goldfish, separated…”
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