Search Results - "Mastroberardino, Pier G."

Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia by Zambetti, Noemi A., Ping, Zhen, Chen, Si, Kenswil, Keane J.G., Mylona, Maria A., Sanders, Mathijs A., Hoogenboezem, Remco M., Bindels, Eric M.J., Adisty, Maria N., Van Strien, Paulina M.H., van der Leije, Cindy S., Westers, Theresia M., Cremers, Eline M.P., Milanese, Chiara, Mastroberardino, Pier G., van Leeuwen, Johannes P.T.M., van der Eerden, Bram C.J., Touw, Ivo P., Kuijpers, Taco W., Kanaar, Roland, van de Loosdrecht, Arjan A., Vogl, Thomas, Raaijmakers, Marc H.G.P.

“…Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and…”
Get full text

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging? by van Beek, Adriaan A., Van den Bossche, Jan, Mastroberardino, Pier G., de Winther, Menno P.J., Leenen, Pieter J.M.

“…Aging is a complex process with an impact on essentially all organs. Declined cellular repair causes increased damage at genomic and proteomic levels upon…”
Get full text

Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function by Birket, Matthew J., Ribeiro, Marcelo C., Kosmidis, Georgios, Ward, Dorien, Leitoguinho, Ana Rita, van de Pol, Vera, Dambrot, Cheryl, Devalla, Harsha D., Davis, Richard P., Mastroberardino, Pier G., Atsma, Douwe E., Passier, Robert, Mummery, Christine L.

“…Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac…”
Get full text

Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease by Sanders, Laurie H, McCoy, Jennifer, Hu, Xiaoping, Mastroberardino, Pier G, Dickinson, Bryan C, Chang, Christopher J, Chu, Charleen T, Van Houten, Bennett, Greenamyre, J.T

“…Abstract DNA damage can cause (and result from) oxidative stress and mitochondrial impairment, both of which are implicated in the pathogenesis of Parkinson's…”
Get full text

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease by Sepe, Sara, Milanese, Chiara, Gabriels, Sylvia, Derks, Kasper W.J., Payan-Gomez, Cesar, van IJcken, Wilfred F.J., Rijksen, Yvonne M.A., Nigg, Alex L., Moreno, Sandra, Cerri, Silvia, Blandini, Fabio, Hoeijmakers, Jan H.J., Mastroberardino, Pier G.

“…The underlying relation between Parkinson’s disease (PD) etiopathology and its major risk factor, aging, is largely unknown. In light of the causative link…”
Get full text

Metals and neurodegeneration by Aizenman, Elias, Mastroberardino, Pier G

Get full text

Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation by van der Pluijm, Ingrid, Burger, Joyce, van Heijningen, Paula M, IJpma, Arne, van Vliet, Nicole, Milanese, Chiara, Schoonderwoerd, Kees, Sluiter, Willem, Ringuette, Lea-Jeanne, Dekkers, Dirk H W, Que, Ivo, Kaijzel, Erik L, te Riet, Luuk, MacFarlane, Elena G, Das, Devashish, van der Linden, Reinier, Vermeij, Marcel, Demmers, Jeroen A, Mastroberardino, Pier G, Davis, Elaine C, Yanagisawa, Hiromi, Dietz, Harry C, Kanaar, Roland, Essers, Jeroen

“…Abstract Aim Thoracic aortic aneurysms are a life-threatening condition often diagnosed too late. To discover novel robust biomarkers, we aimed to better…”
Get full text

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering by Milanese, Chiara, Bombardieri, Cíntia R., Sepe, Sara, Barnhoorn, Sander, Payán-Goméz, César, Caruso, Donatella, Audano, Matteo, Pedretti, Silvia, Vermeij, Wilbert P., Brandt, Renata M. C., Gyenis, Akos, Wamelink, Mirjam M., de Wit, Annelieke S., Janssens, Roel C., Leen, René, van Kuilenburg, André B. P., Mitro, Nico, Hoeijmakers, Jan H. J., Mastroberardino, Pier G.

“…Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations…”
Get full text

Orthogonal analysis of mitochondrial function in Parkinson’s disease patients by Barnhoorn, Sander, Milanese, Chiara, Li, Tracy, Dons, Lieke, Ghazvini, Mehrnaz, Sette, Martina, Farina, Stefania, Sproviero, Daisy, Payan-Gomez, Cesar, Mastroberardino, Pier G.

“…The etiopathology of Parkinson’s disease has been associated with mitochondrial defects at genetic, laboratory, epidemiological, and clinical levels. These…”
Get full text

Pilocapine alters NMDA receptor expression and function in hippocampal neurons: NADPH oxidase and ERK1/2 mechanisms by Di Maio, Roberto, Mastroberardino, Pier G, Hu, Xiaoping, Montero, Laura, Greenamyre, J. Timothy

“…Abstract The molecular basis for epileptogenesis remains poorly defined, but repeated or prolonged seizures can cause altered hippocampal N-methyl d -aspartate…”
Get full text

Direct activating effects of adrenocorticotropic hormone (ACTH) on brown adipose tissue are attenuated by corticosterone by Beukel, Johanna C., Grefhorst, Aldo, Quarta, Carmelo, Steenbergen, Jacobie, Mastroberardino, Pier G., Lombès, Marc, Delhanty, Patric J., Mazza, Roberta, Pagotto, Uberto, Lely, Aart Jan, Themmen, Axel P. N.

“…Brown adipose tissue (BAT) and brownlike cells in white adipose tissue (WAT) can dissipate energy through thermogenesis, a process mediated by uncoupling…”
Get full text

Women have more potential to induce browning of perirenal adipose tissue than men by van den Beukel, Johanna C., Grefhorst, Aldo, Hoogduijn, Martin J., Steenbergen, Jacobie, Mastroberardino, Pier G., Dor, Frank J.M.F., Themmen, Axel P.N.

“…Objective Brown adipose tissue (BAT) can generate heat by burning fatty acids, a process mediated by uncoupling protein 1 (UCP1). White adipose tissue (WAT)…”
Get full text

Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: Implications for epileptogenesis by Di Maio, Roberto, Mastroberardino, Pier G, Hu, Xiaoping, Montero, Laura M, Greenamyre, J. Timothy

“…Abstract Hippocampal sclerosis, the main pathological sign of chronic temporal lobe epilepsy (TLE), is associated with oxidative injury, altered N-methyl d…”
Get full text

A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance by Milanese, Chiara, Mastroberardino, Pier G.

“…Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions…”
Get full text

Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system by Betarbet, Ranjita, Canet-Aviles, Rosa M., Sherer, Todd B., Mastroberardino, Pier G., McLendon, Chris, Kim, Jin-Ho, Lund, Serena, Na, Hye-Mee, Taylor, Georgia, Bence, Neil F., Kopito, Ron, Seo, Byoung Boo, Yagi, Takao, Yagi, Akemi, Klinefelter, Gary, Cookson, Mark R., Greenamyre, J. Timothy

“…Sporadic Parkinson's disease (PD) is most likely caused by a combination of environmental exposures and genetic susceptibilities, although there are rare…”
Get full text

Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging by Sepe, Sara, Nardacci, Roberta, Fanelli, Francesca, Rosso, Pamela, Bernardi, Cinzia, Cecconi, Francesco, Mastroberardino, Pier G, Piacentini, Mauro, Moreno, Sandra

“…Abstract Autophagy is a major protein degradation pathway, essential for stress-induced and constitutive protein turnover. In nervous tissue, autophagy is…”
Get full text

PGC-1α and Reactive Oxygen Species Regulate Human Embryonic Stem Cell-Derived Cardiomyocyte Function by Birket, Matthew J., Casini, Simona, Kosmidis, Georgios, Elliott, David A., Gerencser, Akos A., Baartscheer, Antonius, Schumacher, Cees, Mastroberardino, Pier G., Elefanty, Andrew G., Stanley, Ed G., Mummery, Christine L.

“…Diminished mitochondrial function is causally related to some heart diseases. Here, we developed a human disease model based on cardiomyocytes from human…”
Get full text

The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside by Birkisdóttir, María B, van Galen, Ivar, Brandt, Renata M C, Barnhoorn, Sander, van Vliet, Nicole, van Dijk, Claire, Nagarajah, Bhawani, Imholz, Sandra, van Oostrom, Conny T, Reiling, Erwin, Gyenis, Ákos, Mastroberardino, Pier G, Jaarsma, Dick, van Steeg, Harry, Hoeijmakers, Jan H J, Dollé, Martijn E T, Vermeij, Wilbert P

“…Despite efficient repair, DNA damage inevitably accumulates with time affecting proper cell function and viability, thereby driving systemic aging…”
Get full text

Endocytic iron trafficking and mitochondria in Parkinson’s disease by Cerri, Silvia, Milanese, Chiara, Mastroberardino, Pier G.

“…•Endocytosis is a highly active process and involves large part of the plasma membrane.•Endocytosis is the principal pathway for intracellular iron uptake, an…”
Get full text

Corrigendum: The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside by Birkisdóttir, María B, van Galen, Ivar, Brandt, Renata M C, Barnhoorn, Sander, van Vliet, Nicole, van Dijk, Claire, Nagarajah, Bhawani, Imholz, Sandra, van Oostrom, Conny T, Reiling, Erwin, Gyenis, Ákos, Mastroberardino, Pier G, Jaarsma, Dick, van Steeg, Harry, Hoeijmakers, Jan H J, Dollé, Martijn E T, Vermeij, Wilbert P

“…[This corrects the article DOI: 10.3389/fragi.2022.1005322.]…”
Get full text