Search Results - "Masters, L C"

Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition by CHETELAT, G, VILLEMAGNE, V. L, VILLAIN, N, JONES, G, ELLIS, K. A, AMES, D, MARTINS, R. N, MASTERS, C. L, ROWE, C. C

“…Given the recent and growing interest in the concepts of prodromal and presymptomatic Alzheimer disease, it is crucial to determine whether the presence of…”
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Factors affecting subjective memory complaints in the AIBL aging study: biomarkers, memory, affect, and age by Buckley, R, Saling, M M, Ames, D, Rowe, C C, Lautenschlager, N T, Macaulay, S L, Martins, R N, Masters, C L, O'Meara, T, Savage, G, Szoeke, C, Villemagne, V L, Ellis, K A

“…The prognostic value of subjective memory complaints (SMCs) in the diagnosis of dementia of the Alzheimer's type is unclear. While some studies have found an…”
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Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests by Bates, K A, Verdile, G, Li, Q-X, Ames, D, Hudson, P, Masters, C L, Martins, R N

“…Currently, the ‘amyloid hypothesis’ is the most widely accepted explanation for the pathogenesis of Alzheimer's disease (AD). According to this hypothesis,…”
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Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease by YATES, P. A, SIRISRIRO, R, VILLEMAGNE, V. L, FARQUHARSON, S, MASTERS, C. L, ROWE, C. C

“…Incidental cerebral microhemorrhage (MH) is frequently found in older individuals scanned with susceptibility-weighted MRI (SWI) or gradient-recalled echo MRI…”
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Packaging of prions into exosomes is associated with a novel pathway of PrP processing by Vella, LJ, Sharples, RA, Lawson, VA, Masters, CL, Cappai, R, Hill, AF

“…Prion diseases are fatal, transmissible neurodegenerative disorders associated with conversion of the host‐encoded prion protein (PrPC) into an abnormal…”
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Imaging β-amyloid burden in aging and dementia by ROWE, C. C, NG, S, SMITH, C, WOODWARD, M, MERORY, J, TOCHON-DANGUY, H, O'KEEFE, G, KLUNK, W. E, MATHIS, C. A, PRICE, J. C, MASTERS, C. L, VILLEMAGNE, V. L, ACKERMANN, U, GONG, S. J, PIKE, K, SAVAGE, G, COWIE, T. F, DICKINSON, K. L, MARUFF, P, DARBY, D

“…To compare brain beta-amyloid (Abeta) burden measured with [(11)C]Pittsburgh Compound B (PIB) PET in normal aging, Alzheimer disease (AD), and other dementias…”
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Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing by Brown, B M, Peiffer, J J, Taddei, K, Lui, J K, Laws, S M, Gupta, V B, Taddei, T, Ward, V K, Rodrigues, M A, Burnham, S, Rainey-Smith, S R, Villemagne, V L, Bush, A, Ellis, K A, Masters, C L, Ames, D, Macaulay, S L, Szoeke, C, Rowe, C C, Martins, R N

“…Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to…”
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Amyloid load in Parkinson’s disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography by Edison, P, Rowe, C C, Rinne, J O, Ng, S, Ahmed, I, Kemppainen, N, Villemagne, V L, O’Keefe, G, Någren, K, Chaudhury, K R, Masters, C L, Brooks, D J

“…Background: Neuropathological studies have reported varying amounts of amyloid pathology in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia…”
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A blood-based predictor for neocortical Aβ burden in Alzheimer’s disease: results from the AIBL study by Burnham, S C, Faux, N G, Wilson, W, Laws, S M, Ames, D, Bedo, J, Bush, A I, Doecke, J D, Ellis, K A, Head, R, Jones, G, Kiiveri, H, Martins, R N, Rembach, A, Rowe, C C, Salvado, O, Macaulay, S L, Masters, C L, Villemagne, V L

“…Dementia is a global epidemic with Alzheimer’s disease (AD) being the leading cause. Early identification of patients at risk of developing AD is now becoming…”
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β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia by BOURGEAT, P, CHETELAT, G, ELLIS, K. A, MARTINS, R. N, MASTERS, C. L, ROWE, C. C, SALVADO, O, VILLEMAGNE, V. L, FRIPP, J, RANIGA, P, PIKE, K, ACOSTA, O, SZOEKE, C, OURSELIN, S, AMES, D

“…To investigate whether global and regional beta-amyloid (Abeta) burden as measured with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal…”
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Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt–Jakob disease by Collins, S. J., Sanchez-Juan, P., Masters, C. L., Klug, G. M., van Duijn, C., Poleggi, A., Pocchiari, M., Almonti, S., Cuadrado-Corrales, N., de Pedro-Cuesta, J., Budka, H., Gelpi, E., Glatzel, M., Tolnay, M., Hewer, E., Zerr, I., Heinemann, U., Kretszchmar, H. A., Jansen, G. H., Olsen, E., Mitrova, E., Alpérovitch, A., Brandel, J.-P., Mackenzie, J., Murray, K., Will, R. G.

“…To validate the provisional findings of a number of smaller studies and explore additional determinants of characteristic diagnostic investigation results…”
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Adherence to a Mediterranean diet and Alzheimer’s disease risk in an Australian population by Gardener, S, Gu, Y, Rainey-Smith, S R, Keogh, J B, Clifton, P M, Mathieson, S L, Taddei, K, Mondal, A, Ward, V K, Scarmeas, N, Barnes, M, Ellis, K A, Head, R, Masters, C L, Ames, D, Macaulay, S L, Rowe, C C, Szoeke, C, Martins, R N

“…The Mediterranean diet (MeDi), due to its correlation with a low morbidity and mortality for many chronic diseases, has been widely recognised as a healthy…”
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Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth by Needham, BE, Wlodek, ME, Ciccotosto, GD, Fam, BC, Masters, CL, Proietto, J, Andrikopoulos, S, Cappai, R

“…The amyloid precursor protein (APP), the source of the neurotoxic amyloid β (Aβ) peptide involved in Alzheimer's disease (AD), belongs to a conserved family of…”
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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease by Melrose, H.L, Kent, C.B, Taylor, J.P, Dachsel, J.C, Hinkle, K.M, Lincoln, S.J, Mok, S.S, Culvenor, J.G, Masters, C.L, Tyndall, G.M, Bass, D.I, Ahmed, Z, Andorfer, C.A, Ross, O.A, Wszolek, Z.K, Delldonne, A, Dickson, D.W, Farrer, M.J

“…Abstract Pathogenic substitutions in leucine-rich repeat kinase 2 ( LRRK2 , Lrrk2) have been genetically linked to familial, late-onset Parkinsonism. End-stage…”
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Novel prion protein gene mutation presenting with subacute PSP-like syndrome by ROWE, D. B, LEWIS, V, NEEDHAM, M, RODRIGUEZ, M, BOYD, A, MCLEAN, C, ROBERTS, H, MASTERS, C. L, COLLINS, S. J

“…A 62-year-old Indonesian woman presenting with a progressive supranuclear palsy-like syndrome was confirmed post mortem as dying from a spongiform…”
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Surgical treatment and risk of sporadic Creutzfeldt-Jakob disease: a case-control study by Collins, S, Law, MG, Fletcher, A, Boyd, A, Kaldor, J, Masters, CL

“…Apart from the small number of iatrogenic and familial cases, the cause of most cases of Creutzfeldt-Jakob disease (CJD) is not known. We aimed to identify…”
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Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment by Cheng, L, Doecke, J D, Sharples, R A, Villemagne, V L, Fowler, C J, Rembach, A, Martins, R N, Rowe, C C, Macaulay, S L, Masters, C L, Hill, A F

“…There is no consensus for a blood-based test for the early diagnosis of Alzheimer’s disease (AD). Expression profiling of small non-coding RNA’s, microRNA…”
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Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein by Weidemann, A, Paliga, K, Dürrwang, U, Czech, C, Evin, G, Masters, C. L, Beyreuther, K

“…Mutations in the presenilin genes are associated with early onset familial Alzheimer's disease and lead to increased accumulation of beta A4 peptide, the…”
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What the evolution of the amyloid protein precursor supergene family tells us about its function by Coulson, E.J, Paliga, K, Beyreuther, K, Masters, C.L

“…The Alzheimer’s disease amyloid protein precursor (APP) gene is part of a multi-gene super-family from which sixteen homologous amyloid precursor-like proteins…”
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Australian sporadic CJD analysis supports endogenous determinants of molecular-clinical profiles by LEWIS, V, HILL, A. F, KLUG, G. M, BOYD, A, MASTERS, C. L, COLLINS, S. J

“…To define the protease-resistant prion protein (PrPres) types and associated clinical profiles in Australian patients with sporadic Creutzfeldt-Jakob disease…”
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