Search Results - "Mastbergen, S."

Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; an exploratory study by van Helvoort, E M, Popov-Celeketic, J, Eijkelkamp, N, Coeleveld, K, Tryfonidou, M A, Wijne, C D, Hack, C E, Lafeber, F P J G, Mastbergen, S C

“…An ideal disease modifying osteoarthritis drug (DMOAD) has chondroprotective, anti-inflammatory, and analgesic effects. This study describes the production and…”
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Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis? Data from the IMI-APPROACH cohort by Jansen, M. P., Hodgins, D., Mastbergen, S. C., Kloppenburg, M., Blanco, F. J., Haugen, I. K., Berenbaum, F., Eckstein, F., Roemer, F. W., Wirth, W.

“…Objective To determine the association between joint structure and gait in patients with knee osteoarthritis (OA). Methods IMI-APPROACH recruited 297 clinical…”
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Local and systemic inflammatory lipid profiling in a rat model of osteoarthritis with metabolic dysregulation by de Visser, H M, Mastbergen, S C, Ravipati, S, Welsing, P M J, Pinto, F C, Lafeber, F P J G, Chapman, V, Barrett, D A, Weinans, H

“…Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of…”
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The molecular profile of synovial fluid changes upon joint distraction and is associated with clinical response in knee osteoarthritis by Watt, F.E., Hamid, B., Garriga, C., Judge, A., Hrusecka, R., Custers, R.J.H., Jansen, M.P., Lafeber, F.P., Mastbergen, S.C., Vincent, T.L.

“…Surgical knee joint distraction (KJD) leads to clinical improvement in knee osteoarthritis (OA) and also apparent cartilage regeneration by magnetic resonance…”
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Performance of knee image digital analysis of radiographs of patients with end-stage knee osteoarthritis by Jansen, M.P., Welsing, P.M.J., Vincken, K.L., Mastbergen, S.C.

“…Knee Image Digital Analysis (KIDA) is standardized radiographic analysis software for measuring osteoarthritis (OA) characteristics. It was validated in mild…”
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Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage by de Boer, T.N, van Spil, W.E, Huisman, A.M, Polak, A.A, Bijlsma, J.W.J, Lafeber, F.P.J.G, Mastbergen, S.C

“…Summary Objective Adipose tissue is an endocrine tissue releasing adipokines suggested to be involved in the pathogenesis of osteoarthritis (OA). Nevertheless,…”
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Subchondral bone changes after joint distraction treatment for end stage knee osteoarthritis by Mastbergen, S.C., Ooms, A., Turmezei, T.D., MacKay, J.W., Van Heerwaarden, R.J., Spruijt, S., Lafeber, F.P.J.G., Jansen, M.P.

“…Increased subchondral cortical bone plate thickness and trabecular bone density are characteristic of knee osteoarthritis (OA). Knee joint distraction (KJD) is…”
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Synovial membrane-derived mesenchymal progenitor cells from osteoarthritic joints in dogs possess lower chondrogenic-, and higher osteogenic capacity compared to normal joints by Teunissen, M, Ahrens, N. S, Snel, L, Narcisi, R, Kamali, S. A, van Osch, G. J. V. M, Meij, B. P, Mastbergen, S. C, Sivasubramaniyan, K, Tryfonidou, M. A

“…Abstract Background Synovial membrane-derived mesenchymal progenitor cells (SM-MPCs) are a promising candidate for the cell-based treatment of osteoarthritis…”
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Sustained clinical and structural benefit after joint distraction in the treatment of severe knee osteoarthritis by Wiegant, K, van Roermund, P.M, Intema, F, Cotofana, S, Eckstein, F, Mastbergen, S.C, Lafeber, F.P.J.G

“…Summary Background Treatment of severe osteoarthritis (OA) in relatively young patients is challenging. Although successful, total knee prosthesis has a…”
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Knee joint distraction compared with high tibial osteotomy: a randomized controlled trial by van der Woude, J. A. D., Wiegant, K., van Heerwaarden, R. J., Spruijt, S., van Roermund, P. M., Custers, R. J. H., Mastbergen, S. C., Lafeber, F. P. J. G.

“…Purpose Both, knee joint distraction as a relatively new approach and valgus-producing opening-wedge high tibial osteotomy (HTO), are knee-preserving…”
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Initial tissue repair predicts long-term clinical success of knee joint distraction as treatment for knee osteoarthritis by Jansen, M.P., van der Weiden, G.S., Van Roermund, P.M., Custers, R.J.H., Mastbergen, S.C., Lafeber, F.P.J.G.

“…Knee joint distraction (KJD), a joint-preserving surgery for severe osteoarthritis (OA), provides clinical and structural improvement and postpones the need…”
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The fear for adverse bleeding and cardiovascular events in hemophilia patients using (non-)selective non-steroidal anti-inflammatory drugs: A systematic review reporting on safety by van Bergen, E.D.P., Monnikhof, M., Lafeber, F.P.J.G., Schutgens, R.E.G., Mastbergen, S.C., van Vulpen, L.F.D.

“…(Non-)selective non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for musculoskeletal related pain. These cheap and easily accessible drugs may…”
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Differential effects of bleeds on the development of arthropathy – basic and applied issues by Vulpen, L. F. D., Mastbergen, S. C., Lafeber, F. P. J. G., Schutgens, R. E. G.

“…Haemophilia is characterized by a spontaneous bleeding tendency, affecting mainly the synovial joints. Recurrent joint bleeds induce a cascade of inflammatory…”
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Knee joint distraction compared with total knee arthroplasty: a randomised controlled trial by van der Woude, J A D, Wiegant, K, van Heerwaarden, R J, Spruijt, S, Emans, P J, Mastbergen, S C, Lafeber, F P J G

“…Knee joint distraction (KJD) is a relatively new, knee-joint preserving procedure with the goal of delaying total knee arthroplasty (TKA) in young and…”
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Changes in subchondral bone early in the development of osteoarthritis by Mastbergen, S. C., Lafeber, F. P. J. G.

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Human C-reactive protein aggravates osteoarthritis development in mice on a high-fat diet by Kozijn, A.E., Tartjiono, M.T., Ravipati, S., van der Ham, F., Barrett, D.A., Mastbergen, S.C., Korthagen, N.M., Lafeber, F.P.J.G., Zuurmond, A.M., Bobeldijk, I., Weinans, H., Stoop, R.

“…C-reactive protein (CRP) levels can be elevated in osteoarthritis (OA) patients. In addition to indicating systemic inflammation, it is suggested that CRP…”
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In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model by Intema, F, Hazewinkel, H.A.W, Gouwens, D, Bijlsma, J.W.J, Weinans, H, Lafeber, F.P.J.G, Mastbergen, S.C

“…Summary Objective The pathogenesis of osteoarthritis (OA) includes cartilage degeneration, synovial inflammation, and bone changes. Slowly, the sequence and…”
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A short-term evaluation of a thermoplastic polyurethane implant for osteochondral defect repair in an equine model by Korthagen, N.M., Brommer, H., Hermsen, G., Plomp, S.G.M., Melsom, G., Coeleveld, K., Mastbergen, S.C., Weinans, H., van Buul, W., van Weeren, P.R.

“…•Osteochondral defects lead to fibrous repair tissue and deterioration of the surrounding cartilage.•A synthetic implant of appropriate stiffness that allows…”
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IL4-10 fusion protein has chondroprotective, anti-inflammatory and potentially analgesic effects in the treatment of osteoarthritis by Steen-Louws, C., Popov-Celeketic, J., Mastbergen, S.C., Coeleveld, K., Hack, C.E., Eijkelkamp, N., Tryfonidou, M., Spruijt, S., van Roon, J.A.G., Lafeber, F.P.J.G.

“…Effective disease-modifying drugs for osteoarthritis (DMOAD) should preferably have chondroprotective, anti-inflammatory, and analgesic activity combined in a…”
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Biochemical marker research in hemophilic arthropathy: A systematic review by van Bergen, E.D.P., van Vulpen, L.F.D., Schutgens, R.E.G., Mastbergen, S.C., Lafeber, F.P.J.G.

“…Hemophilic arthropathy (HA) causes major morbidity. Breakthrough therapies reduce the bleeding frequency tremendously, but well-defined joint outcome…”
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