Search Results - "Mast, Fred D."

ESCRT-III is required for scissioning new peroxisomes from the endoplasmic reticulum by Mast, Fred D, Herricks, Thurston, Strehler, Kathleen M, Miller, Leslie R, Saleem, Ramsey A, Rachubinski, Richard A, Aitchison, John D

“…Dynamic control of peroxisome proliferation is integral to the peroxisome's many functions. The endoplasmic reticulum (ER) serves as a source of preperoxisomal…”
Get full text

Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites by Woo, Yong H, Ansari, Hifzur, Otto, Thomas D, Klinger, Christen M, Kolisko, Martin, Michálek, Jan, Saxena, Alka, Shanmugam, Dhanasekaran, Tayyrov, Annageldi, Veluchamy, Alaguraj, Ali, Shahjahan, Bernal, Axel, del Campo, Javier, Cihlář, Jaromír, Flegontov, Pavel, Gornik, Sebastian G, Hajdušková, Eva, Horák, Aleš, Janouškovec, Jan, Katris, Nicholas J, Mast, Fred D, Miranda-Saavedra, Diego, Mourier, Tobias, Naeem, Raeece, Nair, Mridul, Panigrahi, Aswini K, Rawlings, Neil D, Padron-Regalado, Eriko, Ramaprasad, Abhinay, Samad, Nadira, Tomčala, Aleš, Wilkes, Jon, Neafsey, Daniel E, Doerig, Christian, Bowler, Chris, Keeling, Patrick J, Roos, David S, Dacks, Joel B, Templeton, Thomas J, Waller, Ross F, Lukeš, Julius, Oborník, Miroslav, Pain, Arnab

“…The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health…”
Get full text

Systems-level reconstruction of kinase phosphosignaling networks regulating endothelial barrier integrity using temporal data by Wei, Ling, Aitchison, John D., Kaushansky, Alexis, Mast, Fred D.

“…Phosphosignaling networks control cellular processes. We built kinase-mediated regulatory networks elicited by thrombin stimulation of brain endothelial cells…”
Get full text

Molecular mechanisms of organelle inheritance: lessons from peroxisomes in yeast by Rachubinski, Richard A, Fagarasanu, Andrei, Mast, Fred D, Knoblach, Barbara

“…Key Points The cytoplasm of eukaryotic cells is elaborately subdivided into membrane-bound compartments called organelles, each precisely tailored for a…”
Get full text

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus by Ketaren, Natalia E, Mast, Fred D, Fridy, Peter C, Olivier, Jean Paul, Sanyal, Tanmoy, Sali, Andrej, Chait, Brian T, Rout, Michael P, Aitchison, John D

“…To date, all major modes of monoclonal antibody therapy targeting SARS-CoV-2 have lost significant efficacy against the latest circulating variants. As…”
Get full text

Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection by Jiang, Yonghou, Duffy, Fergal, Hadlock, Jennifer, Raappana, Andrew, Styrchak, Sheila, Beck, Ingrid, Mast, Fred D, Miller, Leslie R, Chour, William, Houck, John, Armistead, Blair, Duvvuri, Venkata R, Yeung, Winnie, Haglund, Micaela, Wallner, Jackson, Wallick, Julie A, Hardy, Samantha, Oldroyd, Alyssa, Ko, Daisy, Gervassi, Ana, Murray, Kim M, Kaplan, Henry, Aitchison, John D, Heath, James R, Sather, D Noah, Goldman, Jason D, Frenkel, Lisa, Harrington, Whitney E

“…Coronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced…”
Get full text

Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study by Harrington, Whitney E, Yeung, Winnie, Beck, Ingrid A, Mast, Fred D, Houck, John, Styrchak, Sheila, Miller, Leslie R, Li, Song, Haglund, Micaela, Jiang, Yonghou, Armistead, Blair, Wallner, Jackson, Nguyen, Tina, Ko, Daisy, Hardy, Samantha, Oldroyd, Alyssa, Gervassi, Ana, Aitchison, John D, Frenkel, Lisa M

“…Background Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening…”
Get full text

Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes by Bourgeois, Natasha M, Wei, Ling, Ho, Nhi N T, Neal, Maxwell L, Seferos, Denali, Tongogara, Tinotenda, Mast, Fred D, Aitchison, John D, Kaushansky, Alexis

“…Dengue is an arboviral disease causing severe illness in over 500,000 people each year. Currently, there is no way to constrain dengue in the clinic. Host…”
Get full text

Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication by Carter, Christoph C, Mast, Fred D, Olivier, Jean Paul, Bourgeois, Natasha M, Kaushansky, Alexis, Aitchison, John D

“…The mechanistic target of rapamycin (mTOR) functions in two distinct complexes: mTORC1, and mTORC2. mTORC1 has been implicated in the pathogenesis of…”
Get full text

ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis by Herricks, Thurston, Donczew, Magdalena, Mast, Fred D, Rustad, Tige, Morrison, Robert, Sterling, Timothy R, Sherman, David R, Aitchison, John D

“…Antimicrobial-resistant (Mtb) causes over 200,000 deaths each year. Current assays of antimicrobial resistance need knowledge of mutations that confer drug…”
Get full text

Endoplasmic Reticulum-Associated Secretory Proteins Sec20p, Sec39p, and Dsl1p Are Involved in Peroxisome Biogenesis by Perry, Ryan J, Mast, Fred D, Rachubinski, Richard A

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection by Glennon, Elizabeth K.K., Austin, Laura S., Arang, Nadia, Kain, Heather S., Mast, Fred D., Vijayan, Kamalakannan, Aitchison, John D., Kappe, Stefan H.I., Kaushansky, Alexis

“…Plasmodium parasites are highly selective when infecting hepatocytes and induce many changes within the host cell upon infection. While several host cell…”
Get full text

An ancestral role in peroxisome assembly is retained by the divisional peroxin Pex11 in the yeast Yarrowia lipolytica by Chang, Jinlan, Klute, Mary J, Tower, Robert J, Mast, Fred D, Dacks, Joel B, Rachubinski, Richard A

“…The peroxin Pex11 has a recognized role in peroxisome division. Pex11p remodels and elongates peroxisomal membranes prior to the recruitment of dynamin-related…”
Get full text

Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry by Vijayan, Kamalakannan, Cestari, Igor, Mast, Fred D., Glennon, Elizabeth K.K., McDermott, Suzanne M., Kain, Heather S., Brokaw, Alyssa M., Aitchison, John D., Stuart, Kenneth, Kaushansky, Alexis

“…The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes,…”
Get full text

Phylogenetic analysis of glycerol 3-phosphate acyltransferases in opisthokonts reveals unexpected ancestral complexity and novel modern biosynthetic components by Smart, Heather C, Mast, Fred D, Chilije, Maxwell F J, Tavassoli, Marjan, Dacks, Joel B, Zaremberg, Vanina

“…Glycerolipid synthesis represents a central metabolic process of all forms of life. In the last decade multiple genes coding for enzymes responsible for the…”
Get full text

Peroxisome biogenesis: something old, something new, something borrowed by Mast, Fred D, Fagarasanu, Andrei, Knoblach, Barbara, Rachubinski, Richard A

“…Eukaryotic cells are characterized by their varied complement of organelles. One set of membrane-bound, usually spherical compartments are commonly grouped…”
Get full text

One-Cell Doubling Evaluation by Living Arrays of Yeast, ODELAY by Herricks, Thurston, Dilworth, David J, Mast, Fred D, Li, Song, Smith, Jennifer J, Ratushny, Alexander V, Aitchison, John D

“…Cell growth is a complex phenotype widely used in systems biology to gauge the impact of genetic and environmental perturbations. Due to the magnitude of…”
Get full text

A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders by Mast, Fred D, Li, Jing, Virk, Maninder K, Hughes, Sarah C, Simmonds, Andrew J, Rachubinski, Richard A

“…Human peroxisome biogenesis disorders are lethal genetic diseases in which abnormal peroxisome assembly compromises overall peroxisome and cellular function…”
Get full text

Genome-Wide Analysis of Signaling Networks Regulating Fatty Acid-Induced Gene Expression and Organelle Biogenesis by Saleem, Ramsey A., Knoblach, Barbara, Mast, Fred D., Smith, Jennifer J., Boyle, John, Dobson, C. Melissa, Long-O'Donnell, Rose, Rachubinski, Richard A., Aitchison, John D.

“…Reversible phosphorylation is the most common posttranslational modification used in the regulation of cellular processes. This study of phosphatases and…”
Get full text

Peroxisome prognostications: Exploring the birth, life, and death of an organelle by Mast, Fred D, Rachubinski, Richard A, Aitchison, John D

“…Peroxisomes play a central role in human health and have biochemical properties that promote their use in many biotechnology settings. With a primary role in…”
Get full text