Search Results - "Mast, Christof B."

Periodic Melting of Oligonucleotides by Oscillating Salt Concentrations Triggered by Microscale Water Cycles Inside Heated Rock Pores by Ianeselli, Alan, Mast, Christof B., Braun, Dieter

“…To understand the emergence of life, a better understanding of the physical chemistry of primordial non‐equilibrium conditions is essential. Significant salt…”
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Thermal Habitat for RNA Amplification and Accumulation by Salditt, Annalena, Keil, Lorenz M. R., Horning, David P., Mast, Christof B., Joyce, Gerald F., Braun, Dieter

“…The RNA world scenario posits replication by RNA polymerases. On early Earth, a geophysical setting is required to separate hybridized strands after their…”
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Non-equilibrium conditions inside rock pores drive fission, maintenance and selection of coacervate protocells by Ianeselli, Alan, Tetiker, Damla, Stein, Julian, Kühnlein, Alexandra, Mast, Christof B., Braun, Dieter, Dora Tang, T.-Y.

“…Key requirements for the first cells on Earth include the ability to compartmentalize and evolve. Compartmentalization spatially localizes biomolecules from a…”
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Escalation of polymerization in a thermal gradient by Mast, Christof B., Schink, Severin, Gerland, Ulrich, Braun, Dieter

“…For the emergence of early life, the formation of biopolymers such as RNA is essential. However, the addition of nucleotide monomers to existing…”
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Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules by Morasch, Matthias, Liu, Jonathan, Dirscherl, Christina F., Ianeselli, Alan, Kühnlein, Alexandra, Le Vay, Kristian, Schwintek, Philipp, Islam, Saidul, Corpinot, Mérina K., Scheu, Bettina, Dingwell, Donald B., Schwille, Petra, Mutschler, Hannes, Powner, Matthew W., Mast, Christof B., Braun, Dieter

“…Non-equilibrium conditions must have been crucial for the assembly of the first informational polymers of early life, by supporting their formation and…”
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Proton gradients and pH oscillations emerge from heat flow at the microscale by Keil, Lorenz M. R., Möller, Friederike M., Kieß, Michael, Kudella, Patrick W., Mast, Christof B.

“…Proton gradients are essential for biological systems. They not only drive the synthesis of ATP, but initiate molecule degradation and recycling inside…”
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Sequence dependent UV damage of complete pools of oligonucleotides by Kufner, Corinna L., Krebs, Stefan, Fischaleck, Marlis, Philippou-Massier, Julia, Blum, Helmut, Bucher, Dominik B., Braun, Dieter, Zinth, Wolfgang, Mast, Christof B.

“…Understanding the sequence-dependent DNA damage formation requires probing a complete pool of sequences over a wide dose range of the damage-causing exposure…”
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Dry Polymerization of 3′,5′-Cyclic GMP to Long Strands of RNA by Morasch, Matthias, Mast, Christof B., Langer, Johannes K., Schilcher, Pierre, Braun, Dieter

“…Recent progress in the synthesis of nucleotides from prebiotically plausible precursors has opened up new ways to explain the origin of genetic matter…”
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Formation mechanism of thermally controlled pH gradients by Matreux, Thomas, Altaner, Bernhard, Raith, Johannes, Braun, Dieter, Mast, Christof B., Gerland, Ulrich

“…Spatial proton gradients create energy in biological systems and are likely a driving force for prebiotic systems. Due to the fast diffusion of protons, they…”
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Heat flows enrich prebiotic building blocks and enhance their reactivity by Matreux, Thomas, Aikkila, Paula, Scheu, Bettina, Braun, Dieter, Mast, Christof B.

“…The emergence of biopolymer building blocks is a crucial step during the origins of life 1 – 6 . However, all known formation pathways rely on rare pure…”
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Thermal trap for DNA replication by Mast, Christof B, Braun, Dieter

“…The hallmark of living matter is the replication of genetic molecules and their active storage against diffusion. We implement both in the simple…”
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Heat‐Flow‐Driven Nonequilibria for Prebiotic Chemistry by Mast, Christof B.

“…The origin of life, being one of the most fascinating questions in science, is increasingly addressed by interdisciplinary research. In addition to developing…”
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Water cycles in a Hadean CO2 atmosphere drive the evolution of long DNA by Ianeselli, Alan, Atienza, Miguel, Kudella, Patrick W., Gerland, Ulrich, Mast, Christof B., Braun, Dieter

“…Dew is a common form of water that deposits from saturated air on colder surfaces. Although presumably common on primordial Earth, its potential involvement in…”
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A heated rock crack captures and polymerizes primordial DNA and RNA by Dirscherl, Christina F, Ianeselli, Alan, Tetiker, Damla, Matreux, Thomas, Queener, Robbin M, Mast, Christof B, Braun, Dieter

“…Life is based on informational polymers such as DNA or RNA. For their polymerization, high concentrations of complex monomer building blocks are required…”
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Heat-Flow-Driven Oligonucleotide Gelation Separates Single-Base Differences by Morasch, Matthias, Braun, Dieter, Mast, Christof B.

“…DNA phase transitions are often induced by the addition of condensation agents or by dry concentration. Herein, we show that the non‐equilibrium setting of a…”
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High-Fidelity RNA Copying via 2′,3′-Cyclic Phosphate Ligation by Calaça Serrão, Adriana, Wunnava, Sreekar, Dass, Avinash V., Ufer, Lennard, Schwintek, Philipp, Mast, Christof B., Braun, Dieter

“…Templated ligation offers an efficient approach to replicate long strands in an RNA world. The 2′,3′-cyclic phosphate (>P) is a prebiotically available…”
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Sequence self-selection by cyclic phase separation by Bartolucci, Giacomo, Calaça Serrão, Adriana, Schwintek, Philipp, Kühnlein, Alexandra, Rana, Yash, Janto, Philipp, Hofer, Dorothea, Mast, Christof B, Braun, Dieter, Weber, Christoph A

“…The emergence of functional oligonucleotides on early Earth required a molecular selection mechanism to screen for specific sequences with prebiotic functions…”
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Back Cover: Heat-Flow-Driven Oligonucleotide Gelation Separates Single-Base Differences (Angew. Chem. Int. Ed. 23/2016) by Morasch, Matthias, Braun, Dieter, Mast, Christof B.

“…Enzyme‐free sequence selection is an essential process for the emergence of first life. In their Communication on page 6676 ff., C. B. Mast and co‐workers show…”
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Periodic Melting of Oligonucleotides by Oscillating Salt Concentrations Triggered by Microscale Water Cycles Inside Heated Rock Pores by Ianeselli, Alan, Mast, Christof B., Braun, Dieter

“…To understand the emergence of life, a better understanding of the physical chemistry of primordial non‐equilibrium conditions is essential. Significant salt…”
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RNA Oligomerisation without Added Catalyst from 2′,3′‐Cyclic Nucleotides by Drying at Air‐Water Interfaces by Dass, Avinash Vicholous, Wunnava, Sreekar, Langlais, Juliette, Esch, Beatriz, Krusche, Maik, Ufer, Lennard, Chrisam, Nico, Dubini, Romeo C. A., Gartner, Florian, Angerpointner, Severin, Dirscherl, Christina F., Rovó, Petra, Mast, Christof B., Šponer, Judit E., Ochsenfeld, Christian, Frey, Erwin, Braun, Dieter

“…For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step. We found that in alkaline, drying conditions in bulk and at heated…”
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