Contribution of Hla-B51 in the susceptibility and specific clinical features of Behcet's disease in Tunisian patients

Contribution of Hla-B51 in the susceptibility and specific clinical features of Behcet's disease in Tunisian patients

Abstract Background Many researchers have tried to investigate the association of HLA-B51 with the severity and the clinical features of BD with conflicting results. Methods We aimed at investigating the association of HLA-B51 with demographical and clinical manifestations as well as the severity of...

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Bibliographic Details
Published in:European journal of internal medicine Vol. 23; no. 4; pp. 347 - 349
Main Authors: Hamzaoui, Amira, Houman, Mohamed Habib, Massouadia, Meriem, Salem, Thouraya Ben, Khanfir, Monia Smiti, Ghorbel, Imed Ben, Miled, Mohamed
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-06-2012
Subjects:
Adult
Behcet Syndrome - diagnosis
Behcet Syndrome - genetics
Behcet Syndrome - immunology
Behçet disease
Clinical expression
Disease severity
Female
Genetic Predisposition to Disease
Haplotypes
HLA B51
HLA-B27 Antigen - immunology
HLA-B51 Antigen - genetics
HLA-B51 Antigen - immunology
Humans
Internal Medicine
Male
Tunisia
Young Adult
Tunisia
Disease severity
Behçet disease
Clinical expression
HLA B51
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Summary:Abstract Background Many researchers have tried to investigate the association of HLA-B51 with the severity and the clinical features of BD with conflicting results. Methods We aimed at investigating the association of HLA-B51 with demographical and clinical manifestations as well as the severity of BD, by studying 178 native Tunisian BD patients, fulfilling the International Study group criteria for the BD classification recruited from the Department of Internal Medicine, Rabta Hospital in Tunis and compared with 125 native Tunisian healthy age and sex matching volunteers. Results According to our findings, the frequency of HLAB 51 was significantly higher in BD patients than in controls ( p < 0.001). Positive pathergy test (PPT) ( p = 0.01) and retinal vasculitis ( p = 0.045), were significantly more frequent in HLA B51(+) patients, while the frequency of arterial aneurysms ( p = 0.009) and neurological involvement, especially the parenchymal involvement ( p < 0.001), were significantly and clearly higher in HLA B51(−) patients. The patients without HLA B51 had a significantly less severe disease ( p = 0.001). Discussion/conclusion We conclude that HLA B51 is a predisposing marker for BD in our population as in most ethnic groups. It seems to be associated with a subgroup of BD patients characterized by a higher frequency of ocular involvement and PPT, but a lower frequency of arterial aneurysm and neurological involvement, and a less severe disease course.
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ISSN:0953-6205
1879-0828
DOI:10.1016/j.ejim.2011.12.011