Search Results - "Massonnet, Gerald"

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists by Prost, Stéphane, Relouzat, Francis, Spentchian, Marc, Ouzegdouh, Yasmine, Saliba, Joseph, Massonnet, Gérald, Beressi, Jean-Paul, Verhoeyen, Els, Raggueneau, Victoria, Maneglier, Benjamin, Castaigne, Sylvie, Chomienne, Christine, Chrétien, Stany, Rousselot, Philippe, Leboulch, Philippe

“…Although imatinib gives good clinical results in chronic myeloid leukaemia (CML), residual disease attributed to quiescent CML stem cells remains in many…”
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Nanobodies against surface biomarkers enable the analysis of tumor genetic heterogeneity in uveal melanoma patient‐derived xenografts by Crépin, Ronan, Gentien, David, Duché, Angeline, Rapinat, Audrey, Reyes, Cecile, Némati, Fariba, Massonnet, Gérald, Decaudin, Didier, Djender, Selma, Moutel, Sandrine, Desrumeaux, Klervi, Cassoux, Nathalie, Piperno‐Neumann, Sophie, Amigorena, Sebastian, Perez, Franck, Roman‐Roman, Sergio, Marco, Ario

“…Summary Monoclonal antibodies specific for biomarkers expressed on the surface of uveal melanoma (UM) cells would simplify the immune capture and genomic…”
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Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization by Vallerand, David, Massonnet, Gérald, Kébir, Fatima, Gentien, David, Maciorowski, Zofia, De la Grange, Pierre, Sigal-Zafrani, Brigitte, Richardson, Marion, Humbert, Sandrine, Thuleau, Aurélie, Assayag, Franck, de Plater, Ludmilla, Nicolas, André, Scholl, Suzy, Marangoni, Elisabetta, Weigand, Stefan, Roman-Roman, Sergio, Savina, Ariel, Decaudin, Didier

“…Drug discovery efforts have focused on the tumor microenvironment in recent years. However, few studies have characterized the stroma component in…”
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Optimization of tumor xenograft dissociation for the profiling of cell surface markers and nutrient transporters by Petit, Vincent, Massonnet, Gérald, Maciorowski, Zofia, Touhami, Jawida, Thuleau, Aurélie, Némati, Fariba, Laval, Julie, Château-Joubert, Sophie, Servely, Jean-Luc, Vallerand, David, Fontaine, Jean-Jacques, Taylor, Naomi, Battini, Jean-Luc, Sitbon, Marc, Decaudin, Didier

“…Metabolic adaptations and changes in the expression of nutrient transporters are known to accompany tumorigenic processes. Nevertheless, in the context of…”
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Human breast cancer and lymph node metastases express Gb3 and can be targeted by STxB-vectorized chemotherapeutic compounds by Stimmer, Lev, Dehay, Sabrina, Nemati, Fariba, Massonnet, Gerald, Richon, Sophie, Decaudin, Didier, Klijanienko, Jerzy, Johannes, Ludger

“…The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to…”
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Evaluating patient-derived colorectal cancer xenografts as preclinical models by comparison with patient clinical data by Nunes, Manoel, Vrignaud, Patricia, Vacher, Sophie, Richon, Sophie, Lièvre, Astrid, Cacheux, Wulfran, Weiswald, Louis-Bastien, Massonnet, Gerald, Chateau-Joubert, Sophie, Nicolas, André, Dib, Colette, Zhang, Weidong, Watters, James, Bergstrom, Donald, Roman-Roman, Sergio, Bièche, Ivan, Dangles-Marie, Virginie

“…Development of targeted therapeutics required translationally relevant preclinical models with well-characterized cancer genome alterations. Here, by studying…”
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Selumetinib-based therapy in uveal melanoma patient-derived xenografts by Decaudin, Didier, El Botty, Rania, Diallo, Béré, Massonnet, Gerald, Fleury, Justine, Naguez, Adnan, Raymondie, Chloé, Davies, Emma, Smith, Aaron, Wilson, Joanne, Howes, Colin, Smith, Paul D, Cassoux, Nathalie, Piperno-Neumann, Sophie, Roman-Roman, Sergio, Némati, Fariba

“…The prognosis of metastatic uveal melanoma (UM) is among the worst of all human cancers. The identification of near-ubiquitous GNAQ/GNA11 mutations and the…”
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High molecular response rate of polycythemia vera patients treated with pegylated interferon alpha-2a by Kiladjian, Jean-Jacques, Cassinat, Bruno, Turlure, Pascal, Cambier, Nathalie, Roussel, Murielle, Bellucci, Sylvia, Menot, Marie-Laurence, Massonnet, Gerald, Dutel, Jean-Luc, Ghomari, Kamel, Rousselot, Philippe, Grange, Marie-Jose, Chait, Yasmina, Vainchenker, William, Parquet, Nathalie, Abdelkader-Aljassem, Lina, Bernard, Jean-François, Rain, Jean-Didier, Chevret, Sylvie, Chomienne, Christine, Fenaux, Pierre

“…V617F JAK2 mutation is a reliable molecular marker of polycythemia vera (PV), potentially useful to monitor the effect of treatments in this disease. In a…”
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High molecular response rate of polycythemia vera patients treated with pegylated interferon α–2a by Kiladjian, Jean-Jacques, Cassinat, Bruno, Turlure, Pascal, Cambier, Nathalie, Roussel, Murielle, Bellucci, Sylvia, Menot, Marie-Laurence, Massonnet, Gerald, Dutel, Jean-Luc, Ghomari, Kamel, Rousselot, Philippe, Grange, Marie-Jose, Chait, Yasmina, Vainchenker, William, Parquet, Nathalie, Abdelkader-Aljassem, Lina, Bernard, Jean-François, Rain, Jean-Didier, Chevret, Sylvie, Chomienne, Christine, Fenaux, Pierre

“…V617F JAK2 mutation is a reliable molecular marker of polycythemia vera (PV), potentially useful to monitor the effect of treatments in this disease. In a…”
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Abstract 5782: Selumetinib-based therapy in uveal melanoma patient-derived xenografts by Decaudin, Didier, Botty, Rania EL, Diallo, Béré, Massonnet, Gerald, Fleury, Justine, Naguez, Adnan, Dubois, Marine, Davies, Emma J., Smith, Aaron, Wilson, Joanne, Howes, Colin, Smith, Paul, Cassoux, Nathalie, Mariani, Pascale, Piperno-Neumann, Sophie, Roman, Sergio Roman, Nemati, Fariba

“…Abstract Purpose: The prognosis of metastatic uveal melanoma (UM) patients remains one of the worst observed in human cancers. The identification of frequently…”
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Abstract 2087: The MEK1/2 inhibitor selumetinib (AZD6244; ARRY-142886) appears as an efficient targeted therapy when used in an adjuvant setting in patient-derived xenografts of uveal melanoma by Diallo, Béré, Massonnet, Gerald, El-Botty, Rania, Raymondie, Chloé, Carita, Guillaume, Roman-Roman, Sergio, Smith, Paul, Davies, Emma, Decaudin, Didier, Némati, Fariba

“…Abstract Uveal melanomas (UM) constitute the most common primary intraocular tumors in adults and are characterized by a constitutive activation of the MAPK…”
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Abstract B142: Dissociation of preclinical primary human cancer xenografts for cell surface transportome profiling by Petit, Vincent, Massonnet, Gerald, Maciorowski, Zofia, Touhami, Jawida, Fontaine, Jean-Jacques, Thuleau, Aurelie, Laval, Julie, Chateau-Joubert, Sophie, Battini, Jean-Luc, Sitbon, Marc, Decaudin, Didier

“…Abstract Background: Tumor cell metabolism is of growing interest in both basic and clinical cancer research. A better understanding of underlying molecular…”
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The V617F JAK2 Mutation Is Very Uncommon in Idiopathic Erythrocytosis by Cassinat, Bruno, Parquet, Nathalie, Kiladjian, Jean-Jacques, Massonnet, Gerald, Menot, Marie-Laurence, Chomienne, Christine

“…The V617F JAK2 mutation is highly frequent in Polycythemia Vera (PV) patients. Indeed, we and others found the mutation in 70 to 90% of PV patients. However…”
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Abstract POSTER-THER-1404: in vivo synergism between chemotherapy and the 3C23K monoclonal antibody directed against the anti-müllerian hormone type II receptor in ovarian cancer patient-derived xenografts by Némati, Fariba, Barret, Jean-Marc, Massonnet, Gérald, Bougherara, Houcine, Frère-Belda, Marie-Aude Le, Prost, Jean-François, Decaudin, Didier

“…Abstract Purpose of the study: Müllerian inhibiting substance, also called anti-Müllerian hormone (AMH), belongs to the TGF-β family and plays a key role…”
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Erosion of the chronic myeloid leukaemia stem cell pool by PPAR[gamma] agonists by Prost, Stéphane, Relouzat, Francis, Spentchian, Marc, Ouzegdouh, Yasmine, Saliba, Joseph, Massonnet, Gérald, Beressi, Jean-Paul, Verhoeyen, Els, Raggueneau, Victoria, Maneglier, Benjamin, Castaigne, Sylvie, Chomienne, Christine, Chrétien, Stany, Rousselot, Philippe, Leboulch, Philippe

“…Whether cancer is maintained by a small number of stem cells or is composed of proliferating cells with approximate phenotypic equivalency is a central…”
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Erosion Of The Chronic Myeloid Leukemia Stem Cell Pool By PPARγ Agonists by Prost, Stephane, Relouzat, Francis, Spenchian, Marc, Massonnet, Gérald, Beressi, Jean-Paul, Verhoeyen, Els, Maneglier, Benjamin, Castaigne, Sylvie, Chomienne, Christine, Chretien, Stany, Rousselot, Philippe, Leboulch, Philippe

“…Whether cancer is maintained by a small number of stem cells or is composed of proliferating cells with approximate phenotypic equivalency is a central…”
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The humanized anti-human AMHRII mAb 3C23K exerts an anti-tumor activity against human ovarian cancer through tumor-associated macrophages by Bougherara, Houcine, Némati, Fariba, Nicolas, André, Massonnet, Gérald, Pugnière, Martine, Ngô, Charlotte, Le Frère-Belda, Marie-Aude, Leary, Alexandra, Alexandre, Jérôme, Meseure, Didier, Barret, Jean-Marc, Navarro-Teulon, Isabelle, Pèlegrin, André, Roman-Roman, Sergio, Prost, Jean-François, Donnadieu, Emmanuel, Decaudin, Didier

“…Müllerian inhibiting substance, also called anti-Müllerian hormone (AMH), inhibits proliferation and induces apoptosis of AMH type II receptor-positive tumor…”
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Abstract LB-161: Colospheres: 3D ex vivo microtumors with more aggressive phenotype than original human colon cancer tissues by Weiswald, Louis-Bastien, Massonnet, Gérald, Richon, Sophie, Guinebretiere, Jean-Marc, Bellet, Dominique, Bieche, Ivan, Dangles-Marie, Virginie

“…Abstract The ex vivo colospheres are a newly characterised three-dimensional colon cancer multicellular model, derived from mechanically dissociated human…”
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