Search Results - "Masson, Glenn"

Towards a model of GCN2 activation by Masson, Glenn R

“…Cells must be able to sense and adapt to their surroundings to thrive in a dynamic environment. Key to adapting to a low nutrient environment is the Integrated…”
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A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response by Neill, Graham, Masson, Glenn R

“…ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is…”
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The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria by Ravenhill, Benjamin J., Boyle, Keith B., von Muhlinen, Natalia, Ellison, Cara J., Masson, Glenn R., Otten, Elsje G., Foeglein, Agnes, Williams, Roger, Randow, Felix

“…Xenophagy, a selective autophagy pathway that protects the cytosol against bacterial invasion, relies on cargo receptors that juxtapose bacteria and phagophore…”
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Fundamentals of HDX-MS by Vinciauskaite, Vanesa, Masson, Glenn R

“…Hydrogen deuterium exchange mass spectrometry (HDX-MS) is becoming part of the standard repertoire of techniques used by molecular biologists to investigate…”
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Activation of GCN2 by the ribosomal P-stalk by Inglis, Alison J., Masson, Glenn R., Shao, Sichen, Perisic, Olga, McLaughlin, Stephen H., Hegde, Ramanujan S., Williams, Roger L.

“…Cells dynamically adjust their protein translation profile to maintain homeostasis in changing environments. During nutrient stress, the kinase general control…”
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GCN2: roles in tumour development and progression by Gold, Lyssa T, Masson, Glenn R

“…GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid…”
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Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes by Rostislavleva, Ksenia, Soler, Nicolas, Ohashi, Yohei, Zhang, Lufei, Pardon, Els, Burke, John E., Masson, Glenn R., Johnson, Chris, Steyaert, Jan, Ktistakis, Nicholas T., Williams, Roger L.

“…Phosphatidylinositol 3-kinase Vps34 complexes regulate intracellular membrane trafficking in endocytic sorting, cytokinesis, and autophagy. We present the 4.4…”
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Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA) by Burke, John E, Perisic, Olga, Masson, Glenn R, Vadas, Oscar, Williams, Roger L

“…The p110α catalytic subunit (PIK3CA) is one of the most frequently mutated genes in cancer. We have examined the activation of the wild-type p110α/p85α and a…”
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Structural Mechanisms of PTEN Regulation by Masson, Glenn R, Williams, Roger L

“…The tumor suppressor (PTEN) is a tightly regulated enzyme responsible for dephosphorylating the progrowth lipid messenger molecule phosphatidylinositol…”
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Architecture of human Rag GTPase heterodimers and their complex with mTORC1 by Anandapadamanaban, Madhanagopal, Masson, Glenn R, Perisic, Olga, Berndt, Alex, Kaufman, Jonathan, Johnson, Chris M, Santhanam, Balaji, Rogala, Kacper B, Sabatini, David M, Williams, Roger L

“…The Rag guanosine triphosphatases (GTPases) recruit the master kinase mTORC1 to lysosomes to regulate cell growth and proliferation in response to amino acid…”
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The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity by Masson, Glenn R, Perisic, Olga, Burke, John E, Williams, Roger L

“…Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a lipid and protein phosphatase, and both activities are necessary for its role as a tumour…”
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An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery by Masson, Glenn R, Jenkins, Meredith L, Burke, John E

“…Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful methodology to study protein dynamics, protein folding, protein-protein interactions, and…”
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Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments by Masson, Glenn R., Burke, John E., Ahn, Natalie G., Anand, Ganesh S., Borchers, Christoph, Brier, Sébastien, Bou-Assaf, George M., Engen, John R., Englander, S. Walter, Faber, Johan, Garlish, Rachel, Griffin, Patrick R., Gross, Michael L., Guttman, Miklos, Hamuro, Yoshitomo, Heck, Albert J. R., Houde, Damian, Iacob, Roxana E., Jørgensen, Thomas J. D., Kaltashov, Igor A., Klinman, Judith P., Konermann, Lars, Man, Petr, Mayne, Leland, Pascal, Bruce D., Reichmann, Dana, Skehel, Mark, Snijder, Joost, Strutzenberg, Timothy S., Underbakke, Eric S., Wagner, Cornelia, Wales, Thomas E., Walters, Benjamin T., Weis, David D., Wilson, Derek J., Wintrode, Patrick L., Zhang, Zhongqi, Zheng, Jie, Schriemer, David C., Rand, Kasper D.

“…Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the…”
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Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab11 and its effectors by Burke, John E., Inglis, Alison J., Perisic, Olga, Masson, Glenn R., McLaughlin, Stephen H., Rutaganira, Florentine, Shokat, Kevan M., Williams, Roger L.

“…Phosphatidylinositol 4-kinases (PI4Ks) and small guanosine triphosphatases (GTPases) are essential for processes that require expansion and remodeling of…”
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Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling by Buckles, Thomas C., Ziemba, Brian P., Masson, Glenn R., Williams, Roger L., Falke, Joseph J.

“…Cellular pathways controlling chemotaxis, growth, survival, and oncogenesis are activated by receptor tyrosine kinases and small G-proteins of the Ras…”
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Analysis of phosphoinositide 3-kinase inhibitors by bottom-up electron-transfer dissociation hydrogen/deuterium exchange mass spectrometry by Masson, Glenn R, Maslen, Sarah L, Williams, Roger L

“…Until recently, one of the major limitations of hydrogen/deuterium exchange mass spectrometry (HDX-MS) was the peptide-level resolution afforded by proteolytic…”
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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration by Gong, Grace Q., Bilanges, Benoit, Allsop, Ben, Masson, Glenn R., Roberton, Victoria, Askwith, Trevor, Oxenford, Sally, Madsen, Ralitsa R., Conduit, Sarah E., Bellini, Dom, Fitzek, Martina, Collier, Matt, Najam, Osman, He, Zhenhe, Wahab, Ben, McLaughlin, Stephen H., Chan, A. W. Edith, Feierberg, Isabella, Madin, Andrew, Morelli, Daniele, Bhamra, Amandeep, Vinciauskaite, Vanesa, Anderson, Karen E., Surinova, Silvia, Pinotsis, Nikos, Lopez-Guadamillas, Elena, Wilcox, Matthew, Hooper, Alice, Patel, Chandni, Whitehead, Maria A., Bunney, Tom D., Stephens, Len R., Hawkins, Phillip T., Katan, Matilda, Yellon, Derek M., Davidson, Sean M., Smith, David M., Phillips, James B., Angell, Richard, Williams, Roger L., Vanhaesebroeck, Bart

“…Harnessing the potential beneficial effects of kinase signalling through the generation of direct kinase activators remains an underexplored area of drug…”
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Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex by Ohashi, Yohei, Soler, Nicolas, García Ortegón, Miguel, Zhang, Lufei, Kirsten, Marie L., Perisic, Olga, Masson, Glenn R., Burke, John E., Jakobi, Arjen J., Apostolakis, Apostolos A., Johnson, Christopher M., Ohashi, Maki, Ktistakis, Nicholas T., Sachse, Carsten, Williams, Roger L.

“…The phosphatidylinositol 3-kinase Vps34 is part of several protein complexes. The structural organization of heterotetrameric complexes is starting to emerge,…”
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PTEN regulates cilia through Dishevelled by Shnitsar, Iryna, Bashkurov, Mikhail, Masson, Glenn R., Ogunjimi, Abiodun A., Mosessian, Sherly, Cabeza, Eduardo Aguiar, Hirsch, Calley L., Trcka, Daniel, Gish, Gerald, Jiao, Jing, Wu, Hong, Winklbauer, Rudolf, Williams, Roger L., Pelletier, Laurence, Wrana, Jeffrey L., Barrios-Rodiles, Miriam

“…Cilia are hair-like cellular protrusions important in many aspects of eukaryotic biology. For instance, motile cilia enable fluid movement over epithelial…”
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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace by Heimhalt, Maren, Berndt, Alex, Wagstaff, Jane, Anandapadamanaban, Madhanagopal, Perisic, Olga, Maslen, Sarah, McLaughlin, Stephen, Yu, Conny Wing-Heng, Masson, Glenn R, Boland, Andreas, Ni, Xiaodan, Yamashita, Keitaro, Murshudov, Garib N, Skehel, Mark, Freund, Stefan M, Williams, Roger L

“…The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated…”
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