Search Results - "Massignani, Enrico"

Proteomics profiling of arginine methylation defines PRMT5 substrate specificity by Musiani, Daniele, Bok, Jabez, Massignani, Enrico, Wu, Liling, Tabaglio, Tommaso, Ippolito, Marica Rosaria, Cuomo, Alessandro, Ozbek, Umut, Zorgati, Habiba, Ghoshdastider, Umesh, Robinson, Robert C, Guccione, Ernesto, Bonaldi, Tiziana

“…Protein arginine methyltransferases (PRMTs) catalyze arginine methylation on both chromatin-bound and cytoplasmic proteins. Accumulating evidence supports the…”
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Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation by Fong, Jia Yi, Pignata, Luca, Goy, Pierre-Alexis, Kawabata, Kimihito Cojin, Lee, Stanley Chun-Wei, Koh, Cheryl M., Musiani, Daniele, Massignani, Enrico, Kotini, Andriana G., Penson, Alex, Wun, Cheng Mun, Shen, Yudao, Schwarz, Megan, Low, Diana HP, Rialdi, Alexander, Ki, Michelle, Wollmann, Heike, Mzoughi, Slim, Gay, Florence, Thompson, Christine, Hart, Timothy, Barbash, Olena, Luciani, Genna M., Szewczyk, Magdalena M., Wouters, Bas J., Delwel, Ruud, Papapetrou, Eirini P., Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Minden, Mark D., Jin, Jian, Melnick, Ari, Bonaldi, Tiziana, Abdel-Wahab, Omar, Guccione, Ernesto

“…Cancer-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur in leukemias, as well as in a variety of solid tumors, and confer…”
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Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML by Nicosia, Luciano, Boffo, Francesca Ludovica, Ceccacci, Elena, Conforti, Fabio, Pallavicini, Isabella, Bedin, Fabio, Ravasio, Roberto, Massignani, Enrico, Somervaille, Tim C. P., Minucci, Saverio, Bonaldi, Tiziana

“…The histone demethylase LSD1 is over-expressed in hematological tumors and has emerged as a promising target for anticancer treatment, so that several LSD1…”
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PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin by Musiani, Daniele, Giambruno, Roberto, Massignani, Enrico, Ippolito, Marica Rosaria, Maniaci, Marianna, Jammula, Sriganesh, Manganaro, Daria, Cuomo, Alessandro, Nicosia, Luciano, Pasini, Diego, Bonaldi, Tiziana

“…Protein arginine methyltransferase 1 (PRMT1) is overexpressed in various human cancers and linked to poor response to chemotherapy. Various PRMT1 inhibitors…”
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Biochemical and Computational Approaches for the Large-Scale Analysis of Protein Arginine Methylation by Mass Spectrometry by Musiani, Daniele, Massignani, Enrico, Cuomo, Alessandro, Yadav, Avinash, Bonaldi, Tiziana

“…The absence of efficient mass spectrometry-based approaches for the large-scale analysis of protein arginine methylation has hindered the understanding of its…”
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Systematic Analysis of the Impact of R-Methylation on RBPs-RNA Interactions: A Proteomic Approach by Maniaci, Marianna, Boffo, Francesca Ludovica, Massignani, Enrico, Bonaldi, Tiziana

“…RNA binding proteins (RBPs) bind RNAs through specific RNA-binding domains, generating multi-molecular complexes known as ribonucleoproteins (RNPs). Various…”
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ProMetheusDB: An In-Depth Analysis of the High-Quality Human Methyl-proteome by Massignani, Enrico, Giambruno, Roberto, Maniaci, Marianna, Nicosia, Luciano, Yadav, Avinash, Cuomo, Alessandro, Raimondi, Francesco, Bonaldi, Tiziana

“…Protein arginine (R) methylation is a post-translational modification involved in various biological processes, such as RNA splicing, DNA repair, immune…”
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PRMT1-mediated methylation of the microprocessor-associated proteins regulates microRNA biogenesis by Spadotto, Valeria, Giambruno, Roberto, Massignani, Enrico, Mihailovich, Marija, Maniaci, Marianna, Patuzzo, Francesca, Ghini, Francesco, Nicassio, Francesco, Bonaldi, Tiziana

“…MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Microprocessor and its associated…”
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hmSEEKER: Identification of hmSILAC Doublets in MaxQuant Output Data by Massignani, Enrico, Cuomo, Alessandro, Musiani, Daniele, Jammula, SriGanesh, Pavesi, Giulio, Bonaldi, Tiziana

“…Heavy methyl Stable Isotope Labeling with Amino acids in Cell culture (hmSILAC) is a metabolic labeling strategy employed in proteomics to increase the…”
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Abstract 4731: Therapeutic targeting of RNA splicing through inhibition of protein arginine methylation by Fong, Jia Yi, Low, Diana, Pignata, Luca, Kawabata, Kimihito Cojin, Lee, Stanley CW, Koh, Cheryl, Musiani, Daniele, Massignani, Enrico, Wun, Cheng Mun, Goy, Pierre-Alexis V., Shen, Yudao, Wollmann, Heike, Gay, Florence PH, Luciani, Genna, Barsyte, Dalia, Jin, Jian, Melnick, Ari M., Bonaldi, Tiziana, Abdel-Wahab, Omar, Guccione, Ernesto

“…Abstract Mutations in RNA splicing factors commonly occur in myeloid leukemia and solid tumors. These mutations occur in a heterozygous manner and confer…”
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