Search Results - "Masserini, Massimo E"
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Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
Published in International journal of molecular sciences (01-06-2024)“…Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are…”
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The Influence of Lipid Electric Charge on the Binding of Aβ(1-42) Amyloid Peptide to Bilayers in the Liquid-Ordered State
Published in Biomolecules (Basel, Switzerland) (01-03-2024)“…The amyloidogenic Aβ peptides are widely considered as a pathogenic agent in Alzheimer's disease. Aβ(1-42) would form aggregates of amyloid fibrils on the…”
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The Binding of Aβ42 Peptide Monomers to Sphingomyelin/Cholesterol/Ganglioside Bilayers Assayed by Density Gradient Ultracentrifugation
Published in International journal of molecular sciences (29-02-2020)“…The binding of Aβ42 peptide monomers to sphingomyelin/cholesterol (1:1 mol ratio) bilayers containing 5 mol% gangliosides (either GM1, or GT1b, or a mixture of…”
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Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells
Published in Nanomedicine (01-10-2011)“…Abstract The loss of synapses and neurons in Alzheimer's disease (AD) is thought to be at least partly induced by toxic species formed by the amyloid beta (Aβ)…”
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Lipid-based nanoparticles with high binding affinity for amyloid-β1–42 peptide
Published in Biomaterials (01-09-2010)“…Abstract The neurotoxic beta-amyloid peptide (Aβ), formed in anomalous amounts in Alzheimer’s disease (AD), is released as monomer and then undergoes…”
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β-Amyloid (1–42) peptide adsorbs but does not insert into ganglioside-containing phospholipid membranes in the liquid-disordered state: modelling and experimental studies
Published in International journal of biological macromolecules (01-12-2020)“…β-Amyloid (Aβ) is a 39–43 residue peptide involved in the pathogenesis of Alzheimer's disease. Aβ deposits onto the cells and gives rise to the plaques that…”
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Liposomes functionalized with acidic lipids rescue A[beta]-induced toxicity in murine neuroblastoma cells
Published in Nanomedicine (01-10-2011)“…The loss of synapses and neurons in Alzheimer's disease (AD) is thought to be at least partly induced by toxic species formed by the amyloid beta (A[beta])…”
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Lipid-based nanoparticles with high binding affinity for amyloid- beta 1-42 peptide
Published in Biomaterials (01-09-2010)“…The neurotoxic beta-amyloid peptide (A beta ), formed in anomalous amounts in Alzheimer's disease (AD), is released as monomer and then undergoes aggregation…”
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Lipid-based nanoparticles with high binding affinity for amyloid-beta1-42 peptide
Published in Biomaterials (01-09-2010)“…The neurotoxic beta-amyloid peptide (Abeta), formed in anomalous amounts in Alzheimer's disease (AD), is released as monomer and then undergoes aggregation…”
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