Search Results - "Massarweh, G."

Time-efficient and convenient synthesis of [ 18F]altanserin for human PET imaging by a new work-up procedure by Massarweh, G., Kovacevic, M., Rosa-Neto, P., Evans, A.C., Diksic, M., Schirrmacher, R.

“…[ 18F]Altanserin, an important PET radioligand for the in vivo imaging of the 5-HT 2A receptor, was synthesized from its precursor nitro-altanserin in DMF or…”
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Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging by Therriault, Joseph, Benedet, Andrea L, Pascoal, Tharick A, Savard, Melissa, Ashton, Nicholas J, Chamoun, Mira, Tissot, Cecile, Lussier, Firoza, Kang, Min Su, Bezgin, Gleb, Wang, Tina, Fernandes-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Zetterberg, Henrik, Blennow, Kaj, Saha-Chaudhuri, Paramita, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

“…Amyloid-β deposition into plaques is a pathologic hallmark of Alzheimer disease appearing years before the onset of symptoms. Although cerebral amyloid-β…”
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Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages by Pascoal, Tharick A, Benedet, Andrea L, Tudorascu, Dana L, Therriault, Joseph, Mathotaarachchi, Sulantha, Savard, Melissa, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Kang, Min Su, Stevenson, Jenna, Massarweh, Gassan, Guiot, Marie-Christine, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro

“…Tracking longitudinal tau tangles accumulation across the Alzheimer's disease continuum is crucial to better understand the natural history of tau pathology…”
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Biomarker modeling of Alzheimer's disease using PET-based Braak staging by Therriault, Joseph, Pascoal, Tharick A, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Bezgin, Gleb, Servaes, Stijn, Benedet, Andrea L, Ashton, Nicholas J, Karikari, Thomas K, Lantero-Rodriguez, Juan, Kunach, Peter, Wang, Yi-Ting, Fernandez-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro

“…Gold-standard diagnosis of Alzheimer's disease (AD) relies on histopathological staging systems. Using the topographical information from [ F]MK6240 tau…”
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The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of 18F MK6240 Tau PET in Target Regions by Tissot, C., Servaes, S., Lussier, F. Z., Ferrai-Souza, J. P., Therriault, J., Ferreirat, P. C., Bezgin, G., Bellaver, B., Leffa, D. T., Mathotaarachchi, S. S., Chamoun, M., Stevenson, J., Rahmouni, N., Kang, M. S., Pallen, V., Margherita-Poltronetti, N., Wang, Y. T., Fernandez-Arias, J., Lessa Benedet, Andréa, Zimmer, E. R., Soucy, J. P., Tudorascu, D. L., Cohen, A. D., Sharp, M., Gauthier, S., Massarweh, G., Lopresti, B., Klunk, W. E., Baker, S. L., Villemagne, V. L., Rosa-Neto, P., Pascoal, T. A.

“…6-(fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F] MK6240) tau PET tracer quantifies the brain tau neurofibrillary tangle load in…”
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Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer’s disease therapeutic by Kang, Min Su, Shin, Monica, Ottoy, Julie, Aliaga, Arturo Aliaga, Mathotaarachchi, Sulantha, Quispialaya, Kely, Pascoal, Tharick A, Collins, D Louis, Chakravarty, M. Mallar, Mathieu, Axel, Sandelius, Åsa, Blennow, Kaj, Zetterberg, Henrik, Massarweh, Gassan, Soucy, Jean-Paul, Cuello, A Claudio, Gauthier, Serge, Waterston, Michael, Yoganathan, Nathan, Lessard, Etienne, Haqqani, Arsalan, Rennie, Kerry, Stanimirovic, Danica, Chakravarthy, Balu, Rosa-Neto, Pedro

“…In vivo biomarker abnormalities provide measures to monitor therapeutic interventions targeting amyloid-β pathology as well as its effects on downstream…”
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Plasma pTau‐217 and N‐terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid‐β positive individuals by Woo, Marcel S., Tissot, Cécile, Lantero‐Rodriguez, Juan, Snellman, Anniina, Therriault, Joseph, Rahmouni, Nesrine, Macedo, Arthur C., Servaes, Stijn, Wang, Yi‐Ting, Arias, Jaime Fernandez, Hosseini, Seyyed Ali, Chamoun, Mira, Lussier, Firoza Z., Benedet, Andrea L., Ashton, Nicholas J., Karikari, Thomas K., Triana‐Baltzer, Gallen, Kolb, Hartmuth C., Stevenson, Jenna, Mayer, Christina, Kobayashi, Eliane, Massarweh, Gassan, Friese, Manuel A., Pascoal, Tharick A., Gauthier, Serge, Zetterberg, Henrik, Blennow, Kaj, Rosa‐Neto, Pedro

“…INTRODUCTION We set out to identify tau PET‐positive (A+T+) individuals among amyloid‐beta (Aβ) positive participants using plasma biomarkers. METHODS In this…”
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14-3-3 ζ/δ-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2 by Woo, M. S., Nilsson, J., Therriault, J., Rahmouni, N., Brinkmalm, A., Lessa Benedet, Andréa, Ashton, Nicholas J., Macedo, A. C., Servaes, S., Wang, Y. T., Tissot, C., Arias, J. F., Hosseini, S. A., Chamoun, M., Lussier, F. Z., Karikari, Thomas, Stevenson, J., Mayer, C., Ferrari-Souza, J. P., Kobayashi, E., Massarweh, G., Friese, M. A., Pascoal, T. A., Gauthier, S., Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, P.

“…Introduction Synaptic loss is closely associated with tau aggregation and microglia activation in later stages of Alzheimer's disease (AD). However, synaptic…”
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