Search Results - "Mason W. Freeman"

Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension by Freeman, Mason W., Halvorsen, Yuan-Di, Marshall, William, Pater, Mackenzie, Isaacsohn, Jon, Pearce, Catherine, Murphy, Brian, Alp, Nicholas, Srivastava, Ajay, Bhatt, Deepak L., Brown, Morris J.

“…In patients with treatment-resistant hypertension and blood pressure of 130/80 mm Hg or higher, the aldosterone synthase inhibitor baxdrostat reduced blood…”
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Results from a phase 1, randomized, double-blind, multiple ascending dose study characterizing the pharmacokinetics and demonstrating the safety and selectivity of the aldosterone synthase inhibitor baxdrostat in healthy volunteers by Freeman, Mason W, Bond, Mary, Murphy, Brian, Hui, James, Isaacsohn, Jonathan

“…Baxdrostat is a selective inhibitor of aldosterone synthase designed for the treatment of disorders associated with elevated aldosterone. This study evaluated…”
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Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice by Manning-Tobin, Jennifer J., Moore, Kathryn J., Seimon, Tracie A., Bell, Susan A., Sharuk, Maia, Alvarez-Leite, Jacqueline I., de Winther, Menno P.J., Tabas, Ira, Freeman, Mason W.

“…The scavenger receptors SR-A and CD36 have been implicated in macrophage foam cell formation during atherogenesis and in the regulation of inflammatory…”
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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways by Freeman, Mason W, Björkbacka, Harry, Kunjathoor, Vidya V, Moore, Kathryn J, Koehn, Stephanie, Ordija, Christine M, Lee, Melinda A, Means, Terry, Halmen, Kristen, Luster, Andrew D, Golenbock, Douglas T

“…Atherosclerosis, the leading cause of death in developed countries, has been linked to hypercholesterolemia for decades. More recently, atherosclerotic lesion…”
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Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages by Kunjathoor, Vidya V., Febbraio, Maria, Podrez, Eugene A., Moore, Kathryn J., Andersson, Lorna, Koehn, Stephanie, Rhee, Jeongmi S., Silverstein, Roy, Hoff, Henry F., Freeman, Mason W.

“…Modification of low density lipoprotein (LDL) can result in the avid uptake of these lipoproteins via a family of macrophage transmembrane proteins referred to…”
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ABCA12 Maintains the Epidermal Lipid Permeability Barrier by Facilitating Formation of Ceramide Linoleic Esters by Zuo, Ying, Zhuang, Debbie Z., Han, Rong, Isaac, Giorgis, Tobin, Jennifer J., McKee, Mary, Welti, Ruth, Brissette, Janice L., Fitzgerald, Michael L., Freeman, Mason W.

“…Harlequin ichthyosis is a congenital scaling syndrome of the skin in which affected infants have epidermal hyperkeratosis and a defective permeability barrier…”
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ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol by Fitzgerald, Michael L, Xavier, Ramnik, Haley, Kathleen J, Welti, Ruth, Goss, Julie L, Brown, Cari E, Zhuang, Debbie Z, Bell, Susan A, Lu, Naifang, Mckee, Mary, Seed, Brian, Freeman, Mason W

“…The highly branched mammalian lung relies on surfactant, a mixture of phospholipids, cholesterol, and hydrophobic proteins, to reduce intraalveolar surface…”
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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus by Kurt-Jones, Evelyn A, Popova, Lana, Kwinn, Laura, Haynes, Lia M, Jones, Les P, Tripp, Ralph A, Walsh, Edward E, Freeman, Mason W, Golenbock, Douglas T, Anderson, Larry J, Finberg, Robert W

“…The innate immune system contributes to the earliest phase of the host defense against foreign organisms and has both soluble and cellular pattern recognition…”
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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades by Bjorkbacka, Harry, Fitzgerald, Katherine A, Huet, Francois, Li, Xiaoman, Gregory, James A, Lee, Melinda A, Ordija, Christine M, Dowley, Nicole E, Golenbock, Douglas T, Freeman, Mason W

“…1 Lipid Metabolism Unit, Department of Molecular Biology, Massachusetts General Hospital, Boston 2 Division of Infectious Disease and Immunology, University of…”
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Local Injection of Bevacizumab (Avastin) and Angiolytic KTP Laser Treatment of Recurrent Respiratory Papillomatosis of the Vocal Folds: A Prospective Study by Zeitels, Steven M., Barbu, Anca M., Landau-Zemer, Tali, Lopez-Guerra, Gerardo, Burns, James A., Friedman, Aaron D., Freeman, Mason W., Halvorsen, Yuan-Di, Hillman, Robert E.

“…Objectives: Photoangiolytic laser treatment of recurrent respiratory papillomatosis (RRP) is effective, but does not reliably prevent recurrence. Therefore,…”
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Safety and Dosing of Bevacizumab (Avastin) for the Treatment of Recurrent Respiratory Papillomatosis by Best, Simon R., Friedman, Aaron D., Landau-Zemer, Tali, Barbu, Anca M., Burns, James A., Freeman, Mason W., Halvorsen, Yuan-Di, Hillman, Robert E., Zeitels, Steven M.

“…Objectives: Increasing evidence supports the use of laryngeal injections of the antiangiogenic agent bevacizumab (Avastin) for the adjuvant treatment of…”
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Abca7 Null Mice Retain Normal Macrophage Phosphatidylcholine and Cholesterol Efflux Activity despite Alterations in Adipose Mass and Serum Cholesterol Levels by Kim, Woojin Scott, Fitzgerald, Michael L., Kang, Kihwa, Okuhira, Kei-ichiro, Bell, Susan A., Manning, Jennifer J., Koehn, Stephanie L., Lu, Naifang, Moore, Kathryn J., Freeman, Mason W.

“…Mutations in the A class of ATP-binding cassette transporters (ABCA) are causally implicated in three human diseases: Tangier disease (ABCA1), Stargadt's…”
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Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial by Bakris, George L, Pitt, Bertram, Weir, Matthew R, Freeman, Mason W, Mayo, Martha R, Garza, Dahlia, Stasiv, Yuri, Zawadzki, Rezi, Berman, Lance, Bushinsky, David A

“…IMPORTANCE: Hyperkalemia is a potentially life-threatening condition predominantly seen in patients treated with renin-angiotensin-aldosterone system (RAAS)…”
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Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment by HELLER, Eric A, LIU, Emerson, FREEMAN, Mason W, MOORE, Kathryn J, LUSTER, Andrew D, GERSZTEN, Robert E, TAGER, Andrew M, SINHA, Sumita, ROBERTS, Jesse D, KOEHN, Stephanie L, LIBBY, Peter, AIKAWA, Elena Rabkin, JI QIU CHEN, HUANG, Paul

“…It is known that 5-lipoxygenase and its product, leukotriene B4 (LTB4), are highly expressed in several human pathologies, including atherosclerotic plaque…”
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Distinct Roles of Pattern Recognition Receptors CD14 and Toll-Like Receptor 4 in Acute Lung Injury by Jeyaseelan, Samithamby, Chu, Hong Wei, Young, Scott K, Freeman, Mason W, Worthen, G Scott

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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An overview of the process, progress, and outcomes of a National Center for Accelerated Innovation: The Boston Biomedical Innovation Center Experience by Antman, Elliott M., Freeman, Mason W., Golan, David E., Kitterman, Roger, McKenna, Erin, Parrish, John, Vaughan, Cheryl, Watts, Lesley, Loscalzo, Joseph

“…Implementation of clinically useful research discoveries in the academic environment is challenged by limited funding for early phase proof-of-concept studies…”
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Naturally Occurring Mutations in the Largest Extracellular Loops of ABCA1 Can Disrupt Its Direct Interaction with Apolipoprotein A-I by Fitzgerald, Michael L., Morris, Andrea L., Rhee, Jeongmi S., Andersson, Lorna P., Mendez, Armando J., Freeman, Mason W.

“…The ABCA1 transporter contains two large domains into which many of the genetic mutations in individuals with Tangier disease fall. To investigate the…”
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Endogenous β-glucocerebrosidase activity in Abca12−/−epidermis elevates ceramide levels after topical lipid application but does not restore barrier function by Haller, Jorge F., Cavallaro, Paul, Hernandez, Nicholas J., Dolat, Lee, Soscia, Stephanie J., Welti, Ruth, Grabowski, Gregory A., Fitzgerald, Michael L., Freeman, Mason W.

“…ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12−/− skin has increased glucosylceramide (GlcCer) and…”
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Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake by Moore, Kathryn J, Freeman, Mason W

“…Atherosclerotic vascular disease arises as a consequence of the deposition and retention of serum lipoproteins in the artery wall. Macrophages in lesions have…”
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Cross-Linking and Lipid Efflux Properties of ApoA-I Mutants Suggest Direct Association between ApoA-I Helices and ABCA1 by Chroni, Angeliki, Liu, Tong, Fitzgerald, Michael L, Freeman, Mason W, Zannis, Vassilis I

“…To explore the functional interactions between apoA-I and ABCA1, we correlated the cross-linking properties of several apoA-I mutants with their ability to…”
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